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Comprehensive pediatric study examines viral load, immune response and hyperinflammation in pediatric COVID-19
About Alessio Fasano, MD
Dr. Fasano directs the Mucosal Immunology and Biology Research Center and is associate chief for Basic, Clinical and Translational Research. Under his leadership, investigators are studying the molecular mechanisms of autoimmune disorders, including celiac disease, and other gluten-related disorders.
At the Center for Celiac Research and Treatment, Dr. Fasano specializes in the treatment of patients of all ages with gluten-related disorders, including celiac disease, wheat allergy and gluten sensitivity. He treats patients with acute and chronic diarrheal diseases, and treats infants and children who have difficult-to-treat gastrointestinal problems.
He has been named visiting professor of pediatrics at Harvard Medical School. He authored the groundbreaking study in 2003 that established the rate of celiac disease at one in 133 Americans. Widely sought after by national and international media, Dr. Fasano has been featured in hundreds of interviews including outlets such as The New York Times, The Wall Street Journal; National Public Radio; CNN; Bloomberg News, and others.
Departments, Centers, & Programs:
Clinical Interests:
- Celiac disease
- Dermatitis herpetiformis
- Gluten ataxia
- Gluten-related disorders
- Non-celiac gluten sensitivity
- Wheat allergy
Treats:
- Adult & Pediatrics
Languages:
- Italian, Spanish
Locations
Mass General Brigham for Children: Pediatric Gastroenterology & Nutrition Program
55 Fruit St.
Yawkey Center for Outpatient Care
Suite 6B
Boston, MA 02114
Phone: 617-726-8705
Medical Education
- MD, University of Naples School of Medicine
- Residency, University of Naples School of Medicine
Accepted Insurance Plans
- Aetna
- Beech Street
- Blue Cross Blue Shield
- Blue Cross Blue Shield Medicare
- Cigna
- Commonwealth Care Alliance
- Coventry
- Fallon Health
- Harvard Pilgrim Health Care
- Humana
- Maine Community Health Options
- Mass General Brigham Health Plan
- MassHealth
- Medicaid CT
- Medicaid ME
- Medicaid NH
- Medicaid RI
- Medicaid VT
- Medicare
- Medicare ACO
- Multiplan
- Senior Whole Health
- TriCare
- Tufts Health Plan
- United Health Care
- Wellpoint
- WellSense
- WellSense NH
Note: This provider may accept more insurance plans than shown; please call the practice to find out if your plan is accepted.
Research
Dr. Fasano is director of the Mucosal Immunology and Biology Research Center at Mass General for Children. Dr. Fasano's research established that celiac disease affects approximately 1 percent of the U.S. population, a significantly higher number than previously believed, and helped define gluten sensitivity as a condition on the spectrum of gluten-related disorders. His research also uncovered the role that impairment of the tight junctions between intestinal enterocytes plays in the development of celiac disease.
During research designed to develop a cholera vaccine, Dr. Fasano uncovered a toxin, zonula occludens, which causes diarrhea by loosening the tight junctions and allowing intestinal permeability. Subsequently, he identified the protein zonulin, which controls this process. He has since established the role of zonulin in the pathogenesis of a number of autoimmune diseases, including celiac disease, type 1 diabetes, and certain cancers and diseases of the nervous system.
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