Departments, Centers, & Programs:
Neurosciences Intensive Care Unit
55 Fruit Street
Boston, MA 02114-2696
- PhD, Austral University
- MD, University of Buenos Aires School of Medicine
- Residency, Brigham and Women's Hospital
- Residency, Miami Nicklaus Children's Hospital
- Fellowship, Massachusetts General Hospital
American Board Certifications
- Neurology with Special Qualifications in Child Neurology, American Board of Psychiatry and Neurology
Accepted Insurance Plans
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My translational and clinical research lab explores the relationship of mutant genes to specific biochemical defects and their contribution to cerebrovascular disease such as stroke, white matter disease and neuroinflammation. More specifically, my research focuses on how genetically determined brain endothelial cell-to-cell interactions underlay a broader category of vascular diseases and can be treated by molecular interventions. Cerebrovascular diseases have been traditionally approached in categories of disease where normal physiology is altered by rupture, occlusion or inflammatory processes affecting the brain vessels. A number of single gene disorders have expanded our understanding of some of the mechanisms underlying the pathophysiology of stroke and vascular malformations (i.e: CADASIL, CARASIL, Loeys-Dietz, HHT, inherited thrombophilias and ACTA2). The multiple layers of the vascular system are integrated structurally where functions are maintained and governed by discrete molecular signaling and control mechanisms populations. A tailored approach to their normal and pathological mechanisms, based on genetic and molecular biology, is now within the reach of our conceptual framework and experimental methods. Studying monogenic disorders enhances our knowledge of cerebrovascular diseases and allow for innovative, high-risk interventions such as gene therapy, as well as new delivery systems based on molecular insights.