About Kerry Reynolds, MD

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Dr. Kerry Reynolds is a physician at the Massachusetts General Hospital Cancer Center and Instructor of Medicine at Harvard Medical School. She currently serves as the Director of the Severe Immunotherapy Complications Service, in addition to being the Clinical Director for the inpatient cancer services at Mass General Cancer Center.

Dr. Reynolds specializes in the care of hospitalized patients. Under her leadership, the Massachusetts General Cancer Center’s inpatient program evaluates and treats over 4,000 patients each year and serves as a core training experience for Harvard Medical School students, residents, and fellows each year.

After completing her own residency, chief residency at Massachusetts General, and fellowship training in Oncology at Dana-Farber/Mass General Brigham Cancer Care, she joined the Harvard Medical School faculty in 2014, where she provides clinical care, supervises and educates trainees, participates in administrative affairs, and conducts research on severe toxicities associated with novel immunotherapy agents.

Her short-term academic and primary research focus is to create a clinical database and tissue collection infrastructure to capture the full national history of immune related adverse events (irAEs), and uncover predictors that will identify patients at highest risk for adverse events associated with immunotherapy, or those destined to be refractory.  The overall goal is to characterize these severe clinical presentations, understand the blueprint of cells/molecules driving these clinical presentations, and ultimately develop new therapeutics to improve the treatment of this unique patient population.

 

Clinical Interests:

Treats:

Locations

MGH Cancer Center, Bartlett Hall
CHX-1 202
55 Fruit Street
Boston, MA 02114
Phone: 617-724-0549
Fax: 617-724-7799

Medical Education

  • MD, University of Missouri School of Medicine
  • Residency, Massachusetts General Hospital
  • Fellowship, Dana Farber Cancer Institute

American Board Certifications

  • Internal Medicine, American Board of Internal Medicine
  • Medical Oncology, American Board of Internal Medicine

Accepted Insurance Plans

Note: This provider may accept more insurance plans than shown; please call the practice to find out if your plan is accepted.


Research

We are in the midst of an exciting revolution in the treatment of cancer. By harnessing and enhancing the body’s immune system using novel therapies such as immune checkpoint inhibitors, we can reduce the amount of tumor burden in patients and, in a subset of patients and cancers, achieve long-lasting remission. However, these therapies are often limited by treatment-induced autoimmune adverse events. They affect nearly every organ system, ranging widely from minor rashes and fevers to severe gastrointestinal, pulmonary, or cardiac complications. Dr. Kerry Reynolds, along with Dr. Chloe Villani, and the Massachusetts General Hospital has taken a lead in this arena by altering our clinical practice model to provide expert multi-disciplinary care by creating the Severe Immunotherapy Complications Service. Importantly, this group is not just involved in the clinical care but they have banded together to set up infrastructure to empower specimen collection and facilitate translational research efforts, in order to understand the mechanisms driving immune-related adverse events (irAEs). Blood/tissue samples are systematically collected in an attempt to develop better therapies to treat autoimmune toxicities while maintaining anti-tumor immunity. The hope is that this will further our understanding of early mechanisms leading to autoimmune diseases and identify novel druggable targets with immunosuppressive potential.  The Severe Immunotherapy Complications Service brings together expertise from a variety of clinical divisions and scientists across the institution to coordinate our care and tackle a critical problem facing many cancer patients today. 

Publications

  • Selected Publications:

    • Reynolds K, et al. Diagnosis and Management of Hepatitis in Patients on Checkpoint Blockade. Oncologist 2018 
    • Mahmood SS, Fradley MG, Cohen JV, Nohria, Reynolds, K et al. Myocarditis in Patients Treated With Immune Checkpoint Inhibitors. J Am Coll Cardiol 2018         
    • Chu J, Choi, J, Ostvar, S, Torchia, J, Reynolds, K et al. Cost-effectiveness of immune checkpoint inhibitors for microsatellite instability-high/mismatch repair deficient metastatic colorectal  cancer. Cancer (In Press) 2018.
    • Reynolds K, et al. Severe immune-related adverse effects (irAE) requiring hospital admission in patients treated with immune checkpoint inhibitors for advanced malignancy: temporal trends and clinical significance. ASCO Meeting, June, 2018.  Criss S, Kong, C, Reynolds, K. Cost-Effectiveness of Durvalumab After Chemoradiation in Stage III Non-Small Cell Lung Cancer. ISPOR Asia Pacific Meeting September, 2018. '
    • Chen ST LJ, Durbin S, Cohen JV, Reynolds K. The role of dermatology consultation in the management of dermatologic immune-related adverse effects (irAE) among hospitalized patients. SDHM, 2018.'
    • Dubey D, David, W, Amata, A, Reynolds, K, et al. Varied Phenotypes and Management of Immune Checkpoint Inhibitor Associated Submitted, 2018.