Dr. Shenoy is Chief of Infection Control for Mass General Brigham healthcare system, a large integrated healthcare system with over 80,000 employees. In this role, she is responsible for the development and implementation of infection control strategies, policies, and measurement across the Mass General Brigham system. She is an Associate Professor of Medicine at Harvard Medical School and an Infectious Diseases physician at Massachusetts General Hospital, where she serves as Medical Director of the Regional Emerging Special Pathogens Treatment Center, one of thirteen federally-funded centers with expertise in preparedness and response for emerging pathogens. Dr. Shenoy served as a voting member of the CDC's Healthcare Infection Control Practices Advisory Committee (HICPAC).

Dr. Shenoy's NIH and CDC-funded research has evaluated the clinical, operational and economic impact of infection control strategies and prevention of healthcare-associated infections through clinical studies and mathematical modeling, use of electronic health records for surveillance, and applied machine-learning techniques. She has led research on clinical decision support to inform evaluation and management of patients with infectious diseases, including isolation and de-isolation protocols and pioneered the development and assessment of virtual reality training for infection prevention and control.  

Dr. Shenoy is a fellow of the Infectious Diseases Society of America and the Society for Healthcare Epidemiology of America (SHEA). She is an elected member of the SHEA Board of Trustees, immediate past Chair of SHEA's Public Policy and Government Affairs Committee, and co-chair of SHEA's Low Level Disinfection Guidelines Committee.