Michael T. Lu, MD, MPH, is Director of AI and Co-Director of the MGH Cardiovascular Imaging Research Center (CIRC), Director of the MGH Imaging Trials Center (MITC), Associate Chair of Imaging Science for the MGH Department of Radiology, and Associate Professor of Radiology at Harvard Medical School.

Dr. Lu's clinical expertise is in cardiovascular imaging, including the acquisition and interpretation of CT, MRI, and ultrasound of the heart and blood vessels.

His research focus is on A) clinical trials of cardiac CT to improve health and B) machine learning to predict health outcomes from multimodal imaging. He is mPI of 1) the Data Coordinating Center (DCC) of the REPRIEVE trial, a multicenter randomized controlled trial of statins to reduce coronary plaque and prevent cardiovascular events in 7,769 persons with HIV, 2)PROACT, a trial of polygenic risk based detection and treatment of coronary artery disease, and 3) the PREEMPT DCC, a 1500 person trial to identify younger individuals with coronary artery disease and reduce coronary plaque. He leads the CT Core Lab for several other clinical trials using change in coronary plaque as a major outcome. Recent work in machine learning predicts long-term mortality, incident lung cancer, longevity, and cardiovascular risk from chest radiograph (x-ray) images, and to automate coronary artery calcium scoring and predict cardiovascular risk on chest CT.

Dr. Lu earned his undergraduate, MD, and MPH degrees from Harvard University. His training included a transitional internship in Surgery and Medicine at Newton-Wellesley Hospital, residency in Diagnostic Radiology at the University of California, San Francisco, fellowship in Thoracic and Cardiac Imaging at MGH, and a NIH T32 fellowship in Cardiac Imaging at MGH.