Dr. Steven E. Arnold is Professor of Neurology at Harvard Medical School. At the Massachusetts General Hospital, Dr. Arnold is the Translational Neurology Head and Managing Director of Interdisciplinary Brain Center and the inaugural E. Gerald Corrigan, PhD Endowed Chair in Alzheimer's Therapeutic Sciences.
Dr. Arnold receivied his M.D. from Boston University. He completed residency training in Psychiatry at the New York State Psychiatric Institute / Columbia Presbyterian Medical Center in New York and then another residency training in Neurology at the University of Iowa Hospitals and Clinics in Iowa City. He also completed fellowship training in Behavioral Neurology / Cognitive Neuroscience and was a post-doctoral associate in Neuroanatomy in Iowa. Dr. Arnold is board certified in both neurology and psychiatry.
After training, Dr. Arnold joined the faculty at the University of Pennsylvania where he was Professor of Psychiatry and Neurology until his move to Massachusetts General Hospital in 2015. While at Penn, Dr. Arnold was Director of the Penn Memory Center, Associate Director and Clinical Core Leader of the Alzheimer’s Disease Core Center, Director of the Geriatric Psychiatry Section, Director of the Cellular and Molecular Neuropathology Program in Psychiatry, and Associate Director of the University of Pennsylvania’s Institute on Aging.
At the Massachusetts General Hospital, Dr. Arnold is the Managing Director of the Interdisciplinary Brain Center, a new collaboration of the Departments of Neurology. Psychiatry and the Martinos Center for Neuroimaging. Its mission is to facilitate the discovery, development, and implementation of promising therapeutics and associated diagnostics for individuals with complex brain disorders that affect cognition, behavior and emotion.
Dr. Arnold has conducted longstanding clinical and laboratory research on neurodegenerative disease pathology, molecular biomarkers and therapeutics for cognitive decline and psychiatric syndromes in late life. He has authored over 350 scientific articles, reviews and chapters. Major scientific activities have included clinicopathological correlation studies relating neurodegenerative disease lesions to cognitive profiles, the molecular neuropathology of schizophrenia, and the relationship of psychological distress to risk, clinical expression and pathology in neurodegenerative dementias. Current scientific interests include biomarkers in brain aging and dementias, metabolic factors driving dementia, and protective factors that account for cognitive resilience in aging, all towards accelerating therapeutics discovery and development in early phase and proof-of-concept clinical trials for neurocognitive disorders.
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