About Bill Hucker, MD, PhD

Dr. Hucker is originally from St. Louis where he attended Washington University and completed medical and graduate school. His doctoral work in Biomedical Engineering focused on the cardiac conduction system. He moved to Boston in 2009 for medical residency at Massachusetts General Hospital, and served as Chief Resident for the Internal Medicine program as well. He completed general cardiology and cardiac electrophysiology fellowships at MGH, as well as a postdoctoral research fellowship with Dr. Ellinor investigating the genetics of atrial fibrillation.

His research interests include the molecular mechanisms of atrial fibrillation, arrhythmia models, and arrhythmia mapping systems. His clinical interests include catheter ablation of atrial and ventricular arrhythmias as well as device implantation.  

Clinical Interests:




Mass General Heart Center
55 Fruit St.
Boston, MA 02114
Phone: 866-644-8910

Mass General Brigham Healthcare Center
102-104 Endicott St.
Danvers, MA 01923
Phone: 978-882-6191

Mass General: Demoulas Center for Cardiac Arrhythmias
55 Fruit St.
Boston, MA 02114
Phone: 617-724-4500

Medical Education

  • PhD, MD, Washington University
  • Residency, Massachusetts General Hospital
  • Fellowship, Massachusetts General Hospital
  • Fellowship, Massachusetts General Hospital

American Board Certifications

  • Cardiovascular Disease, American Board of Internal Medicine
  • Clinical Cardiac Electrophysiology, American Board of Internal Medicine

Accepted Insurance Plans

Note: This provider may accept more insurance plans than shown; please call the practice to find out if your plan is accepted.


I am a physician scientist and cardiac electrophysiologist with a primary research interest to understand the underlying mechanisms of atrial fibrillation (AF) and its role in the development of heart failure. I began my research training studying cellular biomechanics, followed by my graduate work that focused on the cardiac conduction system. After several years of clinical training, I completed postdoctoral research training studying the role of novel genes that were associated with atrial fibrillation and continue in this line of investigation, hoping to identify new treatments for atrial fibrillation.


    1. Hucker WJ, Cohen JA,  et al. WATCHMAN implantation in patients with a history of atrial fibrillation and intracranial hemorrhage. J Interv Card Electrophysiol 2019.
    2. Januzzi JL Jr, Ahmad T, Binder LG, Hucker WJ, et al. 2019 Methodology for Creating Expert Consensus Decision Pathways. J Am Coll Cardiol. 2019.
    3. Weiner, RB, Hucker WJ, et al. Case 25-2018: A 63 year old Man with Syncope. NEJM 2018.
    4. Macri V, Brody JA, Arking DE, Hucker WJ, et al. Common Coding Variants in SCN10A are associated with Nav 1.8 Late Current and Cardiac Conduction. Circ Genom Precis Med. 2018
    5. Leyton-Mange JS*, Hucker WJ*,  et al. Experience with Wearable Cardioverter-Defibrillators at 2 Academic Medical Centers. JACC Clin Electrophysiol. 2018.
    6. Tomaselli GF, Mahaffey KW, Cuker A, Dobesh PP, Doherty JU, Eikelboom JW, Florido R, Hucker WJ, et al. 2017 ACC Expert Consensus Decision Pathway on Management of Bleeding in Patients on Oral Anticoagulants. J Am Coll Cardiol. 2017.
    7. Hulsmans M, Clauss S, Xiao L, Aguirre AD, King KR, Hanley A, Hucker WJ,  et al. Macrophages Facilitate Electrical Conduction in the Heart. Cell. 2017.
    8. Hucker WJ, Hanley A, Ellinor PT. Improving Atrial Fibrillation Therapy: Is There a Gene for That? J Am Coll Cardiol. 2017.
    9. Doherty JU, Gluckman TJ, Hucker WJ,  et al. 2017 ACC Expert Consensus Decision Pathway for Periprocedural Management of Anticoagulation in Patients with Nonvalvular Atrial Fibrillation. J Am Coll Cardiol. 2017.

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