About Raghu Chivukula, MD, PhD

Dr. Chivukula studied cellular and molecular neuroscience at Johns Hopkins University prior to MD and PhD training in genetics at Johns Hopkins University School of Medicine. He completed residency training in internal medicine at Massachusetts General Hospital and clinical fellowships in pulmonary disease and critical care medicine at Harvard Medical School. As an Instructor of Medicine at Harvard Medical School and an attending physician at Massachusetts General Hospital, Dr. Chivukula is actively involved in clinical care, research, and teaching. Dr. Chivukula’s clinical interests include general critical care medicine and genetic forms of lung disease. His research interests center on the function and dysfunction of specialized organelles in the lung, particularly in rare pulmonary disorders. As an educator, Dr. Chivukula participates in teaching medical students, graduate students, residents, and fellows both in didactic and clinical settings.

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Medical Education

  • MD, Johns Hopkins University School of Medicine
  • Residency, Massachusetts General Hospital*****
  • Fellowship, Massachusetts General Hospital*****

American Board Certifications

  • Critical Care Medicine, American Board of Internal Medicine
  • Internal Medicine, American Board of Internal Medicine
  • Pulmonary Disease, American Board of Internal Medicine

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Research

Dr. Chivukula conducts basic scientific research in the Sabatini group at the Whitehead Institute for Biomedical Research. His prior work has elucidated novel in vivo roles for microRNAs in mammals and revealed a previously undescribed form of human lung disease caused by short airway cilia. His current work focuses on the roles of lysosome dysfunction in driving genetic and sporadic forms of interstitial lung disease. Dr. Chivukula’s research has been recognized with the Michael A. Shanoff Award, selection to Forbes Magazine “30 Under 30”, and with selection as a fellow of the Parker B. Francis Foundation.

Publications

  • Chivukula RR*, […] Alkuraya FS*, Sabatini DM. A human ciliopathy reveals essential functions for NEK10 in airway mucociliary clearance. Nature Medicine. 26(2), 244-251 (2020). *corresponding
     
    Chivukula RR, Maley JH, Dudzinski DM, Hibbert, KA, Hardin, CC. Evidence-based management of the critically ill adult with SARS-CoV-2 infection. Journal of Intensive Care Medicine. 10.1177/0885066620969132 (2020).
     
    Taylor MS*, Chivukula RR*, [...] Kradin RL. Delayed alveolar epithelialization: a distinct pathology in diffuse acute lung injury. Am. J. Respir. Crit. Care Med. 197, 522–524 (2018). *equal contribution
     
    Chivukula RR*, Shi G*, [...] Mendell JT. An essential mesenchymal function for miR-143/145 in intestinal epithelial regeneration. Cell 157, 1104-16 (2014). *equal contribution
     
    Kota J, Chivukula RR, [...] Mendell JT. Therapeutic microRNA delivery suppresses tumorigenesis in a murine liver cancer model. Cell 137, 1005–1017 (2009).

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