Eric Schmidt, MD
Eric Schmidt, MD
Chief, Division of Pulmonary and Critical Care Medicine
Physician, Massachusetts General Hospital
Associate Professor of Medicine, Harvard Medical School
Departments, Centers, & Programs:
Mass General Pulmonary & Critical Care
55 Fruit St.
Boston, MA 02114
- MD, University of Pittsburgh School of Medicine
- Residency, Johns Hopkins Hospital
- Fellowship, Johns Hopkins Hospital
American Board Certifications
- Critical Care Medicine, American Board of Internal Medicine
- Internal Medicine, American Board of Internal Medicine
- Pulmonary Disease, American Board of Internal Medicine
Accepted Insurance Plans
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The Schmidt laboratory pursues "bedside-to-bench" mechanistic investigations of sepsis and septic organ injury. We are particularly interested in the function and fate of the endothelial and epithelial glycocalyces during health and critical illness. Using human and animal studies, we identified that sepsis-associated degradation of the endothelial glycocalyx induces local vascular dysfunction (leading to ARDS and acute kidney injury) while simultaneously releasing circulating heparan sulfate fragments that penetrate the hippocampus and impair cognition in sepsis survivors. Our interests extend beyond the vasculature: we have identified the presence and structure of an alveolar epithelial glycocalyx, defined its importance to surfactant homeostasis, and determined the impact of its degradation on secondary bacterial pneumonia pathogenesis and ARDS outcomes. Our laboratory is particularly proud of the numerous successes of its trainees, who have pursued impactful research under F31, F32, K08 (NHLBI, NIA), R03, and foundation (AHA) support.