About Francine Hughes, MD

Francine Hughes, MD, is the chief of the Division of Maternal-Fetal Medicine (MFM) at Massachusetts General Hospital in the Department of Obstetrics and Gynecology and an Associate Professor at Harvard Medical School. Dr. Hughes is board-certified in Obstetrics and Gynecology as well as Maternal-Fetal Medicine. She received her medical degree from Thomas Jefferson and completed her residency at Saint Barnabas Medical Center. She completed both a clinical and a research fellowship at Albert Einstein College of Medicine/Montefiore Medical Center. 

As a maternal-fetal medicine specialist, Dr. Hughes focuses her clinical practice on high-risk pregnancies, including care for women with medical and pregnancy complications and the prenatal diagnosis of congenital malformations, genetic abnormalities, and fetal growth problems. Her clinical interests include diabetes in pregnancy, obesity, and the long-term effects of intrauterine exposures.


Departments, Centers, & Programs:

Clinical Interests:



Mass General Obstetrics and Gynecology
55 Fruit St.
Yawkey Center for Outpatient Care
Suite 4F
Boston, MA 02114
Phone: 617-724-2229

Medical Education

  • MD, Jefferson Medical College, Thomas Jefferson University
  • Residency, Saint Barnabas Medical Center
  • Fellowship, Albert Einstein College of Medicine

American Board Certifications

  • Maternal and Fetal Medicine, American Board of Obstetrics and Gynecology
  • Obstetrics & Gynecology, American Board of Obstetrics and Gynecology

Accepted Insurance Plans

Note: This provider may accept more insurance plans than shown; please call the practice to find out if your plan is accepted.


    • Einstein FH, Atzmon G, Yang XM, Ma XH, Rincon M, Rudin E, Muzumdar R, Barzilai N. Differential Responses of Visceral and Subcutaneous Fat Depots to Nutrients. Diabetes 2005 Mar;54(3):672-678. (PMID: 15734842)
    • Einstein FH, Fishman S, Muzumdar RH, Yang XM, Atzmon G, Barzilai N. Accumulation of Visceral Fat and Insulin Resistance in Pregnant Rats. Am J Physiol Endocrinol Metab 2008 Feb;294(2):E451-5. (PMID: 18073320)
    • Einstein FH, Fishman S, Bauman J, Thompson R, Atzmon G, Barzilai N, Muzumdar RH. Enhanced Activation of a 'Nutrient-Sensing' Pathway with Age Contributes to Insulin Resistance and Inflammation. FASEB J 2008 Oct;22(10):3450-7. (PMID: 18566293)
    • Einstein FH, Thompson RF, Bhagat TD, Fazzari MJ, Verma A, Barzilai N, Greally JM. Cytosine Methylation Dysregulation in Neonates Following Intrauterine Growth Restriction. PLoS One. 2010 Jan 26;5(1):e8887. (PMID: 20126273)
    • Einstein FH, Huffman DM, Fishman S, Jerschow E, Atzmon G, Heo HJ, Atzmon G, Schechter C, Barzilai N, Muzumdar R. Aging per se Increases the Susceptibility to Free Fatty Acid-Induced Insulin Resistance. J Gerontol A Biol Sci Med Sci. 2010 May 26. (PMID: 20504893)
    • Karakash S, Einstein FH. Diabetes and Pregnancy: Glycemia Control Guidelines and Rational. Curr Opin Endocrinol Diabetes Obes. 2011 Apr;18(2):99-103. (PMID: 21330917)
    • Sheen JJ, Heo HJ, Einstein FH. Epigenetics of Obesity and Diabetes. eLS, Jan 2013.
    • Einstein FH. Multigenerational Effects of Maternal Undernutrition. Cell Metab, 2014 Jun 3;19(6):893-4. (PMID: 24896533)
    • Delahaye F, Wijetunga NA, Heo HJ, Tozour JN, Zhoa YM, Greally JM*, Einstein FH*. Sexual Dimorphism in Epigenomic Responses of Stem Cells to Extreme Fetal Growth. Nature Commun. 2014 Oct 10;5:5187. doi: 10.1038/ncomms6187. (PMID: 25300954) *Co-corresponding authors
    • Wijetunga, N. A. Delahaye F, Zhao Y, Golden A, Mar JC, Einstein FH*, Greally J*. The Meta-Epigenomic Structure of Purified Human Stem Cell Populations Is Defined at Cis-Regulatory Sequences. Nature Commun. 5:5195 doi: 10.1038/ncomms6195 (2014). (PMID: 25327398) *Co corresponding authors.
    • Williams L*, Seki Y*, Delahaye F*, Cheng A, Fuloria M, Hughes Einstein F, Charron MJ. DNA Hypermethylation of CD3+ T-cells from Cord Blood of Intrauterine Growth Restricted Humans. Diabetologia. May, 2016. doi:10. 1007/ s00125-016-3983-7 (PMID: 27185256)
    • Suzuki M, Maekawa R, Patterson NE, Reynolds DM, Calder BR, Reznik SE, Heo HJ, Hughes Einstein F, Greally JM. Amnion as a Surrogate Tissue Reporter of the Effects of Maternal Preeclampsia on the Fetus. Clin Epigenetics. 2016 Jun 10;8:67. doi: 10.1186/s13148-016-0234-1 (PMID: 27293492)
    • Heo HJ*, Tozour J*, Delahaye F, Zhao Y, Cui L, Barzilai N, Einstein FH. Advanced Aging Phenotype Is Revealed by Epigenetic Modifications in Rat Liver after in Utero Malnutrition. Aging Cell. 2016 Jul 29. doi: 10.1111/acel.12505. (PMID: 27470058)
    • Winkel AF, Hughes F, Blank SV. Non-Reassuring Status: Improving OBGYN Physician Wellness. Obstet Gynecol. 2017 Nov;130(5):1042-1046. (PMID: 29016500)
    • Tozour JN, Delahaye F, Suzuki M, Zhao Y, Praiss A, Cui L, Heo HJ, Greally JM, Hughes F. Intrauterine Hyperglycemia Is Associated with Impaired Postnatal Response to Oxidative Damage. Stem Cells Dev. 2018 Mar 29. doi: 10.1089/scd.2017.0232. (PMID: 29598691)
    • Hughes F, Bernstein PS. Sexism in Obstetrics and Gynecology: Not just a ?women?s issue?. Am J Obstet Gynecol. 2018 Jul 11. pii: S0002-9378(18)30575-1. doi: 10.1016/j.ajog.2018.07.006. [Epub ahead of print] (PMID: 30017680)
    • Delahaye F, Do C, Kong Y, Ashkar R, Salas M, Tycko B, Wapner R, Hughes F. Functional genomic characterization of human placenta reveals the influence of transcription factors and cell subpopulation in transcriptional regulation. PLoS Genet. 2018 Nov 19;14(11):e1007785. doi: 10.1371/journal.pgen.1007785. eCollection 2018 Nov. (PMID: 30452450)
    • Hughes F, Francis AP, Sciscione AC. Physician Burnout among Members of the Society for Maternal-Fetal Medicine. Am J Perinatol. 2019 Jun 6. doi: 10.1055/s-0039-1692185. (PMID: 31170748)
    • Sagaram D, Hughes F. Physician Burnout and Self-Care. Contemp OB/Gyn. 2020 Sept; 65(9):8-10.
    • Tozour J, Hughes F, Carrier A, Vieau D, Delahaye F. Prenatal Hyperglycemia Exposure and Cellular Stress, a Sugar-Coated View of Early Programming of Metabolic Diseases. Biomolecules 2020 Sep 23;10(10):1359. doi: 10.3390/biom10101359. (PMID: 32977673)
    • Fiorentino DG, Hughes F. Fetal Screening for Chromosomal Abnormalities. Neoreviews. 2021 Dec 1;22(12):e805-e818. Doi:10.1542/neo.22-12-e805.
    • Kuba K, Estrada Trejo F, Lambert C, Vani K, Eisenberg R, Nathan L, Bernstein P, Hughes F. A Novel Evidence-Based Labor Induction Algorithm Associated with Increased Vaginal Delivery Within 24 Hours. Am J Perinatol. 2022 Jun 16. doi: 10.1055/a-1877-8996. Epub ahead of print. PMID: 35709742
    • Pelletier A, Carrier A; Zhao YM; Canouil M, Derhourhi D, Durand E; Berberian-Ferrato L, Greally JM, Hughes F, Froguel F, Bonnefond A, Delahaye F. Epigenetic and transcriptomic programming of HSC quiescence signaling in large for gestational age neonates. Int J Mol Sci. 2022 Jun 30;23(13):7323. doi: 10.3390/ijms23137323. PMID: 35806330; PMCID: PMC9267056.
    • Westcott JM, Hughes F, Liu W, Grivainis M, Hoskins IA, Feny? D. Prediction of Maternal Hemorrhage: A Cohort Study Utilizing Machine Learning to Identify Patients at Risk. J Med Internet Res. 2022 Jul 18;24(7):e34108. PMID: 35849436
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