Dr. Martinez-Lage is a Board Certified neuropathologist and surgical pathologist, member of the Neuropathology and the Head and Neck (ENT) services at MGH. She also collaborates with the Center for Integrated Diagnostics in the molecular diagnosis of brain tumors.



Centers & Specialties

Cancer Center

  • Neuro-Oncology (Brain)
Clinical Interests
  • Neuropathology
  • Molecular pathology
  • Head and Neck Pathology
  • Endocrine pathology
Medical Education
  • MD, University of Cantabria School of Medicine
  • Residency, Hospital de la Santa Creu i Sant Pau|Residency, Hospital of the University of Pennsylvania
  • Fellowship, Hospital de la Santa Creu i Sant Pau|Fellowship, Hospital of the University of Pennsylvania
Board Certifications
  • Anatomic Pathology
  • Neuropathology
Foreign Languages
  • Spanish
  • Boston: Massachusetts Eye and Ear Infirmary
  • Boston: Massachusetts General Hospital
Insurances Accepted
  • Aetna Health Inc.
  • AllWays Health (NHP) - ACD
  • AllWays Health (NHP) - PBO
  • Beech Street
  • Blue Cross Blue Shield - Blue Care 65
  • Blue Cross Blue Shield - Indemnity
  • Blue Cross Blue Shield - Managed Care
  • Blue Cross Blue Shield - Partners Plus
  • BMC HealthNet Mass Health MCO/ACO
  • Cigna (PAL #'s)
  • Commonwealth Care Alliance
  • Fallon Community HealthCare
  • Great-West Healthcare (formally One Health Plan)
  • Harvard Pilgrim Health Plan - ACD
  • Harvard Pilgrim Health Plan - PBO
  • Health Care Value Management (HCVM)
  • Humana/Choice Care PPO
  • Maine Community Health Options (MCHO)
  • MassHealth
  • Medicare
  • Medicare - ACD
  • OSW - Connecticut
  • OSW - Maine
  • OSW - New Hampshire
  • OSW - Rhode Island
  • OSW - Vermont
  • Private Health Care Systems (PHCS)
  • Railroad Medicare
  • Railroad Medicare - ACD
  • Senior Whole Health
  • TriCare
  • Tufts Health Plan
  • Unicare
  • United Healthcare (non-HMO) - ACD
  • United Healthcare (non-HMO) - PBO
  • Well Sense Pediatrics

Note: This provider may accept more insurance plans than shown; please call the practice to find out if your plan is accepted.

Patient Age Group
Provider Gender


Dr. Martinez-Lage received her medical degree from the University of Cantabria in Santander, Spain, and completed residency training in Neurology at the Hospital de la Santa Creu i Sant Pau in Barcelona, Spain. She then decided to pursue a career in Pathology and completed Anatomic Pathology and Neuropathology training, followed by a fellowship in selective Surgical Pathology at the University of Pennsylvania in Philadelphia, where she stayed as Assistant Professor following her training. In 2016 Dr. Martinez-Lage joined the Pathology Service at Massachusetts General Hospital. She has participated in Neuropathology education at diverse national venues such as the ASCP and the USCAP annual meetings, and is a member of the AANP (American Association of Neuropathologists) Education Committee. Her research interests focus on the morphological and molecular diagnosis as well as the immunological microenvironment of brain tumors and other disorders of the nervous system, with an emphasis on translational and clinical applications.


Research & Publications

Research Summary

Current and recent projects include:

  • Study on the immune microenvironment of glioblastoma, and its relationships with survival, molecular subtypes, and other clinicopathological characteristics
  • Analysis of the molecular milieu of glioblastoma in the clinical setting, using next generation sequencing to assess the frequency of coexisting mutations in glioblastoma and their impact in clinical trial selection and therapy guidance
  • Neuropathological aspects of early clinical trials on investigational cell therapy using patients’ own T-cells (CAR-T) modified to recognize EGFRvIII, a mutation seen in glioblastoma
  • Neuropathological correlates of specific MRI parameters in the differentiation of recurrence versus treatment-related changes (“pseudo-progression”) in patients with glioblastoma
  • Pathological assessment of an animal model of glioma to assess key aspects of gliomagenesis, tumor stem cell characteristics, and aggressiveness.
  • Evaluation of the interaction of novel immune therapies with the central and peripheral nervous system
  • Investigation of molecular markers involved in the underlying mechanisms of meningioma progression and meningioma aggressiveness
  • Examination of certain morphological, immunohistochemical, and clinical aspects of pituitary adenomas.

View my most recent publications at PubMed


Pathology Associates
55 Fruit Street
Boston, MA 02114-2696
Phone: 617-726-5156