The Wein laboratory studies molecular mechanisms controlling osteocyte differentiation and function. Our research focuses on transcriptional control of sclerostin, an osteocyte-specific secreted protein that happens to be a drug target for osteoporosis. We are interested in understanding how osteocytes turn on sclerostin, and how signals that boost bone formation (parathyroid hormone, mechanical loading) regulate its expression.
Studies of signaling mechanisms whereby parathyroid hormone regulates gene expression in osteocytes.
Studies of mechanisms whereby mechanical signals regulate gene expression in osteocytes.
Studies to investigate novel mechanisms controlling sclerostin gene expression, focusing on the role of class IIa histone deacetylases (HDACs)