Linemen's rapid weight gain can lead to hardening of heart, arteries, but problems may be offset with increased aerobic training
Corrigan Minehan Heart Center
Explore This Research Lab
Cardiovascular disease, largely due to coronary artery disease, is the leading cause of death in the U.S. and worldwide.
The Natarajan Laboratory at Massachusetts General Hospital uses genomics, biomarkers, bioinformatics, mobile technology, and deep phenotypic learning to discover and understand the causal factors of atherosclerotic cardiovascular disease across diverse populations. These insights are implemented into prospective studies to improve cardiovascular care.
The lab spans the Massachusetts General Hospital Cardiovascular Research Center and Center for Genomic Medicine, Program in Medical & Population Genetics of the Broad Institute of Harvard and MIT, and Harvard Medical School.
For details about our work, including publications, available research positions, and more information for patients, please visit the Natarajan Lab’s main website.
Meet Our Team
Pradeep Natarajan, MD, MMSc, Principal Investigator and Director of Preventive Cardiology at Massachusetts General Hospital, where he oversees prevention, genetics, and cardiac rehabilitation programs for atherosclerotic cardiovascular disease.
Phoebe Finneran, BS, Clinical Research Coordinator
Akhil Pampana, MS, Computational Biologist
Maryam Zekavat, BS, Yale MD/PhD Student
- Patient Story
- Jun | 28 | 2019
On Dec. 20, 2018, Greenfield, Massachusetts resident and tattoo artist Ben Reigle woke up at 3:50 am and was unable to move the right side of his body.
- Press Release
- Jun | 25 | 2019
A biological pathway previously found to contribute to the impact of stress on the risk of cardiovascular disease also may underlie the increased incidence of such disease experienced by individuals with lower socioeconomic status.
- May | 16 | 2019
Researchers recommend exercise training, alone or in combination with CBT, for patients with heart failure who are experiencing depressive symptoms.
- Press Release
- Mar | 6 | 2019
A team led by Massachusetts General Hospital (MGH) investigators has found that activity of an important signaling pathway increases with aging and with heart failure and that inhibiting that pathway can improve cardiac function in mouse models.
- Mar | 1 | 2019
A Massachusetts General Hospital research team has identified a nucleoprotein complex that is responsible for breaking down the arterial wall in aortic aneurysm.