A new health and economic model clearly shows why it’s imperative that food manufacturers reduce the amount of added sugar in their products.
Department of Medicine
Rhee Laboratory: Eugene Ree, MD Endocrine/Nephrology Research
Explore This Research Lab
About the Lab
Our laboratory is jointly supported by the Endocrine and Nephrology Divisions of the Department of Medicine. Our studies on metabolism and renal disease extend naturally from this collaboration and span epidemiologic, physiologic, and experimental approaches, with an emphasis on liquid chromatography, mass spectrometry-based metabolomics. Current projects include: 1.) discovery of metabolite predictors of incident Chronic Kidney Disease (CKD), CKD progression, and cardiovascular outcomes in well-characterized clinical cohorts, 2.) characterization of novel renal metabolic functions using samples acquired with invasive catheterization, and 3.) animal and cell-based studies to test the functional effects of select metabolites and metabolic pathways. We are interested both in metabolites that are important locally for maintaining kidney cell health as well as metabolites that may have a systemic role in metabolism, e.g. in phosphate homeostasis.
Rhee EP, Souza A, Farrell L, Pollak MR, Lewis GD, Steele DJ, Thadhani R, Clish CB, Greka A, Gerszten RE. Metabolite Profiling Identifies Markers of Uremia. J Am Soc Nephrol 2010; 32(6):1041-51.
Rhee EP, Cheng S, Larson MG, Walford GA, Lewis GD, McCabe E, Yang E, Farrell L, Fox CS, O’Donnell CJ, Carr SA, Vasan RS, Florez JC, Clish CB, Wang TJ, Gerszten RE. Lipid Profiling Identifies a Triacylglycerol Signature of Insulin Resistance and Improves Diabetes Prediction in Humans. J Clin Invest 2011; 121(4):1402-11.
Rhee EP, Clish CB, Ghorbani A, Larson MG, Elmariah S, McCabe E, Yang Q, Cheng S, Pierce K, Deik A, Souza AL, Farrell L, Domos C, Yeh RW, Palacios I, Rosenfield K, Vasan RS, Florez JC, Wang TJ, Fox CS, Gerszten RE. A Combined Epidemiologic and Metabolomic Approach Improves Chronic Kidney Disease Prediction. J Am Soc Nephrol 2013; 24(8):1330-8.
Rhee EP,* Ho JE,* Chen MH,* Shen D, Cheng S, Larson MG, Ghorbani A, Shi X, Helenius IT, O’Donnell CJ, Souza AL, Deik A, Pierce KA, Bullock K, Walford GA, Vasan RS, Florez JC, Clish CB, Yeh JR, Wang TJ, Gerszten RE. A Genome-Wide Association Study of the Human Metabolome in a Community Based Cohort. Cell Metab 2013; 18(1):130-43. *equal contribution
Kalim S, Clish CB, Wenger J, Elmariah S, Yeh RW, Deferio J, Pierce K, Deik A, Gerszten RE, Thadhani R, Rhee EP. A plasma long-chain acylcarnitine predicts cardiovascular mortality in incident dialysis patients. J Am Heart Assoc 2013; 2(6):e000542
van Ballegooijen AJ, Rhee EP, Elmariah S, de Boer IH, Kestenbaum B. Renal Clearance of Mineral Metabolism Markers. J Am Soc Nephrol 2016; 27(2): 392-97.
- Chief of Nephrology - Department of Medicine
- Aug | 13 | 2021
In this interview, Kerry Reynolds, MD chats with Meghan Sise, MD, director of onconephrology at Mass General Hospital, to learn more about how immune checkpoint inhibitor (ICI) therapy affects kidney function.
- Press Release
- Jul | 8 | 2021
Las puntuaciones de riesgo genético podrían mejorar la identificación clínica de los pacientes con mayor riesgo de infarto
Un equipo descubrió recientemente que la aplicación de la PRS puede identificar a los pacientes de riesgo que actualmente no se identifican mediante las evaluaciones clínicas estándar.
- Press Release
- Jun | 7 | 2021
Automated emails and letters that provide personalized feedback related to cafeteria purchases at work may help employees make healthier food choices.
- Staff Story
- Nov | 17 | 2020
Winfred W. Williams, MD, has been named a deputy editor of The New England Journal of Medicine. Williams, who is associate chief of the Division of Nephrology, becomes the first African American to serve in that role.
- Press Release
- Sep | 2 | 2020
Mass General study demonstrates that kidneys infected with hepatitis C can be safely transplanted into healthy recipients
Mass General study demonstrates that kidneys infected with hepatitis C can be safely transplanted into healthy recipients.
About the Nephrology Division
The Division of Nephrology at Massachusetts General Hospital is a leading provider of services for patients with kidney disease, including diagnosis and management of kidney diseases and medical management of renal transplantation.