Researchers identify key regulators of urinary concentration in the kidney
The finding could have implications in the treatment of kidney diseases.
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Division of Nephrology
Contact Information
Thier Research Building 1051
50 Blossom Street
Boston,
MA
02114
Phone: 617-643-2888
Email: eprhee@partners.org
Our laboratory is jointly supported by the Endocrine and Nephrology Divisions of the Department of Medicine. Our studies on metabolism and renal disease extend naturally from this collaboration and span epidemiologic, physiologic, and experimental approaches, with an emphasis on liquid chromatography, mass spectrometry-based metabolomics. Current projects include: 1.) discovery of metabolite predictors of incident Chronic Kidney Disease (CKD), CKD progression, and cardiovascular outcomes in well-characterized clinical cohorts, 2.) characterization of novel renal metabolic functions using samples acquired with invasive catheterization, and 3.) animal and cell-based studies to test the functional effects of select metabolites and metabolic pathways. We are interested both in metabolites that are important locally for maintaining kidney cell health as well as metabolites that may have a systemic role in metabolism, e.g. in phosphate homeostasis.
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The finding could have implications in the treatment of kidney diseases.
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In this interview, Kerry Reynolds, MD chats with Meghan Sise, MD, director of onconephrology at Mass General Hospital, to learn more about how immune checkpoint inhibitor (ICI) therapy affects kidney function.
The Division of Nephrology at Massachusetts General Hospital is a leading provider of services for patients with kidney disease, including diagnosis and management of kidney diseases and medical management of renal transplantation.