A drug already in use for several cancers was found effective in a study of leptomeningeal dissemination of cancer.
Department of Medicine
Rhee Laboratory: Eugene Ree, MD Endocrine/Nephrology Research
Explore This Research Lab
About the Lab
Our laboratory is jointly supported by the Endocrine and Nephrology Divisions of the Department of Medicine. Our studies on metabolism and renal disease extend naturally from this collaboration and span epidemiologic, physiologic, and experimental approaches, with an emphasis on liquid chromatography, mass spectrometry-based metabolomics. Current projects include: 1.) discovery of metabolite predictors of incident Chronic Kidney Disease (CKD), CKD progression, and cardiovascular outcomes in well-characterized clinical cohorts, 2.) characterization of novel renal metabolic functions using samples acquired with invasive catheterization, and 3.) animal and cell-based studies to test the functional effects of select metabolites and metabolic pathways. We are interested both in metabolites that are important locally for maintaining kidney cell health as well as metabolites that may have a systemic role in metabolism, e.g. in phosphate homeostasis.
Rhee EP, Souza A, Farrell L, Pollak MR, Lewis GD, Steele DJ, Thadhani R, Clish CB, Greka A, Gerszten RE. Metabolite Profiling Identifies Markers of Uremia. J Am Soc Nephrol 2010; 32(6):1041-51.
Rhee EP, Cheng S, Larson MG, Walford GA, Lewis GD, McCabe E, Yang E, Farrell L, Fox CS, O’Donnell CJ, Carr SA, Vasan RS, Florez JC, Clish CB, Wang TJ, Gerszten RE. Lipid Profiling Identifies a Triacylglycerol Signature of Insulin Resistance and Improves Diabetes Prediction in Humans. J Clin Invest 2011; 121(4):1402-11.
Rhee EP, Clish CB, Ghorbani A, Larson MG, Elmariah S, McCabe E, Yang Q, Cheng S, Pierce K, Deik A, Souza AL, Farrell L, Domos C, Yeh RW, Palacios I, Rosenfield K, Vasan RS, Florez JC, Wang TJ, Fox CS, Gerszten RE. A Combined Epidemiologic and Metabolomic Approach Improves Chronic Kidney Disease Prediction. J Am Soc Nephrol 2013; 24(8):1330-8.
Rhee EP,* Ho JE,* Chen MH,* Shen D, Cheng S, Larson MG, Ghorbani A, Shi X, Helenius IT, O’Donnell CJ, Souza AL, Deik A, Pierce KA, Bullock K, Walford GA, Vasan RS, Florez JC, Clish CB, Yeh JR, Wang TJ, Gerszten RE. A Genome-Wide Association Study of the Human Metabolome in a Community Based Cohort. Cell Metab 2013; 18(1):130-43. *equal contribution
Kalim S, Clish CB, Wenger J, Elmariah S, Yeh RW, Deferio J, Pierce K, Deik A, Gerszten RE, Thadhani R, Rhee EP. A plasma long-chain acylcarnitine predicts cardiovascular mortality in incident dialysis patients. J Am Heart Assoc 2013; 2(6):e000542
van Ballegooijen AJ, Rhee EP, Elmariah S, de Boer IH, Kestenbaum B. Renal Clearance of Mineral Metabolism Markers. J Am Soc Nephrol 2016; 27(2): 392-97.
- Chief of Nephrology - Department of Medicine
- Press Release
- Jun | 2 | 2020
A team led by investigators at Mass General and the Broad Institute of MIT and Harvard recently found that applying “polygenic risk scores” can identify at-risk patients who are not presently identified through standard clinical evaluations.
- Press Release
- May | 15 | 2020
A team led by researchers from Mass General has uncovered key molecular step stones in alcohol-related liver disease that may provide targets for drug therapy development.
- May | 1 | 2020
The National Institute of Allergy and Infectious Diseases (NIAID) reported April 29 that preliminary data from the study indicates that patients with advanced COVID-19 symptoms who received remdesivir recovered 31% faster than similar patients who received a placebo.
- May | 1 | 2020
- Mar | 27 | 2020
El Dr. Raghu Chivukula, MD, PhD, explica lo que se sabe actualmente sobre la droga y su uso para tratar a los pacientes con el COVID-19.
About the Nephrology Division
The Division of Nephrology at Massachusetts General Hospital is a leading provider of services for patients with kidney disease, including diagnosis and management of kidney diseases and medical management of renal transplantation.