Research Spotlight: Comparison of Single-Cell Profiling Methods Reveals Strengths and Limitations
The study will help researchers more efficiently approach projects employing single cell RNA sequencing on human cancer biopsies.
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Dr. Williams studies the genetic basis of chronic allograft nephropathy as an Associate Member of the Broad Institute. Human genome sequencing revealed that the entire autosomal genes may deleted, with some of these gene-deletion alleles being sufficiently common. Because the immune system of an individual with a homozygous gene deletion may not be tolerant to a "foreign" antigen from a donor, such genomic variations may contribute to risk of chronic rejection and alloimmune disease. Studies are being conducted to determine whether donor-recipient mismatch for homozygous gene deletions increases the risk of kidney rejection after transplantation.
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The study will help researchers more efficiently approach projects employing single cell RNA sequencing on human cancer biopsies.
Researchers used computer modeling to evaluate the potential clinical impact and cost-effectiveness of administering long-acting, injectable antibodies to infants from birth to prevent HIV infection during breastfeeding.
Given uncertainties about future PEPFAR funding, researchers modeled the impact of abrupt PEPFAR cutbacks in South Africa
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Uncontrolled blood pressure puts people at increased risk of developing heart disease, brain disease, and kidney disease, yet only one in four people have their blood pressure under good control.
Shadmehr (Shawn) Demehri, MD, PhD, is the corresponding author of a paper published in Cancer Cell, “Commensal papillomavirus immunity preserves the homeostasis of highly mutated normal skin.”
The Division of Nephrology at Massachusetts General Hospital is a leading provider of services for patients with kidney disease, including diagnosis and management of kidney diseases and medical management of renal transplantation.