Arabs represent about 5% of the world population and are massively underrepresented in genomic studies worldwide, yet minimal efforts have been made to date to understand clinical utility of polygenic scores in this group.
About the Lab
Dr. Williams studies the genetic basis of chronic allograft nephropathy as an Associate Member of the Broad Institute. Human genome sequencing revealed that the entire autosomal genes may deleted, with some of these gene-deletion alleles being sufficiently common. Because the immune system of an individual with a homozygous gene deletion may not be tolerant to a "foreign" antigen from a donor, such genomic variations may contribute to risk of chronic rejection and alloimmune disease. Studies are being conducted to determine whether donor-recipient mismatch for homozygous gene deletions increases the risk of kidney rejection after transplantation.
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About the Nephrology Division
The Division of Nephrology at Massachusetts General Hospital is a leading provider of services for patients with kidney disease, including diagnosis and management of kidney diseases and medical management of renal transplantation.