The Multiple Sclerosis (MS) Imaging Laboratory in the Department of Neurology at Massachusetts General Hospital, led by Eric Klawiter, MD, MSc, is focused on developing new imaging techniques to better understand, diagnose and treat MS.
The Multiple Sclerosis (MS) Imaging Lab, directed by Eric Klawiter, MD, MSc, focuses on MS clinical research as well as the application and development of new imaging methods to better understand, diagnose and treat MS.
Through the use of novel imaging techniques, we examine changes in structural and functional brain networks in MS in relation to clinical outcomes such as cognition. The overall goal is to integrate novel imaging techniques into therapeutic clinical trials, which our lab is also involved with.
The goals of our research are to:
Understand the pathology that gives rise to symptoms and cognitive impairment associated with MS
Develop biomarkers for early diagnosis of MS
Develop more effective treatments for MS
Our current imaging dataset consists of data from the 3T Connectom scanner and an ultra-high field 7T scanner on patients with MS including:
Longitudinal structural magnetic resonance imaging (MRI)
Longitudinal resting state functional MRI
Diffusion tensor imaging (DTI)
Advanced diffusion imaging (i.e. Q-ball and axon diameter modeling)
Optical coherence tomography (OCT)
We also plan, implement and write customized code to streamline data processing and analysis.
The MS Imaging Laboratory is involved in various neuroimaging studies that implement established and novel techniques to examine structural and functional connectivity in relationship to cognitive dysfunction in MS.
Spinal Cord Imaging
We are exploring novel spinal cord imaging techniques in MS and related diseases such as neuromyelitis optica (NMO).