Exercise for adults with congenital heart disease poses many unique challenges. In this presentation from August 12, 2021, Sherrin Gallagher, ACNP, AACC, reviews the importance of exercise and current guidelines for adults with congenital heart disease.
How are immune cells able to recognize and kill cells infected with SARS-CoV-2? Why does one person’s lymph nodes mount a strong immune response and another person’s doesn’t?
“We need to answer questions like these to better prepare for future infectious diseases,” says Bruce Walker, MD, director of the Ragon Institute of Mass General Hospital, MIT and Harvard. “For it’s the immune system—the body’s line of defense against infection--that will deliver us from future threats.”
Immunology and vaccinology are still in their infancy, he argues, and while scientists alone can make some headway, a powerful tool could supercharge their work: artificial intelligence.
That’s the idea behind a new initiative by the Ragon Institute, MIT’s Abdul Latif Jameel Clinic for Machine Learning in Health and the MIT Schwarzman College of Computing. Launched with a $2 million gift by longtime Ragon Institute supporters Mark and Lisa Schwartz, the program will fund graduate students and postdoctoral fellows to be mentored by both an MIT faculty member with AI expertise and a Ragon Institute immunologist.
“The human immune system involves trillions of cells communicating with one another. In an immune response, there are so many elements working at the same time that it’s nearly impossible for the human brain to figure out how it’s all interconnected,” says Walker. “The power of this collaboration is that it brings immunologists and computer scientists together, applying a technology that is ideally suited to finding patterns in a complex system.”
In doing so, they can jointly redefine the field, says collaborator Regina Barzilay, PhD, AI faculty lead at the Jameel Clinic and a 2017 MacArthur fellow. “AI has already been successfully applied to many areas of life science,” she says. “Surprisingly, its application to immunology is still in very early stages. While one can readily apply existing tools from computer vision and natural language processing, real breakthroughs in understanding the immune system with AI require development of novel methods that can accurately capture complex, dynamic interactions inherent in the immune response.”
As the COVID-19 pandemic has demonstrated all too well, humankind is extremely vulnerable to new infectious diseases. Says Walker: “The current states of AI and immunology research and the urgency lent by COVID make this the right time for this initiative.”
- Jul | 20 | 2021
In this presentation from July 20, 2021, Dr. Doreen DeFaria Yeh reviews the specific medical issues that develop among children and adults born with a complex congenital heart condition called tetralogy of Fallot.
- Press Release
- Jul | 8 | 2021
Las puntuaciones de riesgo genético podrían mejorar la identificación clínica de los pacientes con mayor riesgo de infarto
Un equipo descubrió recientemente que la aplicación de la PRS puede identificar a los pacientes de riesgo que actualmente no se identifican mediante las evaluaciones clínicas estándar.
- Press Release
- Jul | 6 | 2021
Researchers led by Massachusetts General Hospital have identified a condition with potential cardiovascular disease implications for the many people with HIV not identified by traditional risk markers.
- May | 28 | 2021
Follow the Dr. Paul Dudley White Charles River Bike Path from the Museum of Science to the Galen Street Bridge in Watertown for a scenic 17-mile loop along both shores of the Charles River.
- Press Release
- May | 25 | 2021
The use of accelerometers enables researchers to provide the most objective evidence to date of the link between physical activity and atrial fibrillation.