A team led by investigators at Massachusetts General Hospital (MGH) has uncovered four distinct molecular subtypes of respiratory syncytial virus, or RSV, bronchiolitis and has linked a certain subtype to a higher asthma risk.
- In infants with bronchiolitis, investigators identified five profiles based on the infecting virus and the microbial composition and function in the upper airway.
- Profiles varied by amounts of immune cells and activation states of certain immune pathways.
- Infants had different risks of developing asthma by age five based on these profiles.
Yoshihiko Raita, MD, MPH, MMSc
Our findings may provide an evidence base for the early identification of high-risk children during an important period of airway development.
Department of Emergency Medicine, Massachusetts General Hospital
BOSTON – A type of viral lung infection called bronchiolitis is the leading cause of hospitalizations in U.S. infants as well as a major risk factor for developing asthma. New research led by investigators at Massachusetts General Hospital (MGH) has revealed a complex interplay among the infecting virus, the airway’s microbial composition and function, and the infant’s immune response that all contribute to a child’s risk of developing asthma after bronchiolitis.
The work, which is described in the European Respiratory Journal, relies on metatranscriptome profiles, or microbes’ RNA within certain environments— in this case, the airway of infants with severe bronchiolitis.
After analyzing tissue from the nasopharynx, or the upper part of the throat, of 244 infants hospitalized for bronchiolitis, the team identified five metatranscriptome profiles based on the infecting virus and the microbial composition and function of the nasopharynx. Infants with different metatranscriptome profiles not only had distinct microbial functionat the time of bronchiolitis.
Importantly, infants had different risks of developing asthma by age five based on their metatranscriptome profile. For example, infants with one profile had an approximate 40% risk of developing asthma. Therefore, interactions among the infecting virus, bacteria residing in the nasopharynx, and the infant’s immune system likely affect a child’s risk of developing asthma after severe bronchiolitis.
“Our findings may provide an evidence base for the early identification of high-risk children during an important period of airway development—early infancy—and should facilitate further investigations into the development of metatranscriptome profile–specific strategies for asthma prevention,” says lead author Yoshihiko Raita, MD, MPH, MMSc, a research staff member in the Department of Emergency Medicine at MGH.
This work was supported by the National Institutes of Health.
About the Massachusetts General Hospital
Massachusetts General Hospital, founded in 1811, is the original and largest teaching hospital of Harvard Medical School. The Mass General Research Institute conducts the largest hospital-based research program in the nation, with annual research operations of more than $1 billion and comprises more than 9,500 researchers working across more than 30 institutes, centers and departments. In August 2021, Mass General was named #5 in the U.S. News & World Report list of "America’s Best Hospitals."