- Viruses residing in a normal intestine have anti-inflammatory effects, but viruses isolated from the intestines of patients with inflammatory bowel disease provoke inflammation.
- The findings suggest that patients with inflammatory bowel might benefit from therapies that replace disease-driving intestinal viruses with health-promoting viruses.
Kate. L. Jeffrey, PhD
Our work provides a missing functional link that our collective virome is an important contributor to human health, but when perturbed does provoke inflammation in IBD and conceivably many other diseases.
Investigator, Massachusetts General Hospital
BOSTON – Research in recent years has demonstrated the diverse roles that gut bacteria can play in health and disease, but what about contributions from viruses, which, like bacteria, perpetually reside within the human intestine? New research published in Science Immunology and led by investigators at Massachusetts General Hospital (MGH) indicates that imbalances in the intestine’s viral community—called the virome—may promote inflammatory bowel disease (IBD).
IBD, which includes Crohn’s disease and ulcerative colitis, is characterized by chronic intestinal inflammation and is thought to be caused by a combination of genetics, an overactive immune system response, and environmental triggers.
“The fecal virome is altered in IBD, suggesting a role for viruses in the onset of these conditions. However, we were stalled at correlations,” says senior author Kate. L. Jeffrey, PhD, investigator in the department of Gastroenterology at MGH and an associate professor of medicine at Harvard Medical School. When Jeffrey and her colleagues isolated viruses from patient colon surgical tissue, they found that viruses in a normal intestine had anti-inflammatory effects and contributed to a healthy gut. Conversely, viruses isolated from the inflamed intestines of patients with IBD provoked inflammation. The team categorized the viruses unique to patients with IBD so that their findings might be used in future research and clinical studies.
In additional experiments, mice whose normal intestinal viruses were replaced with viruses from healthy human colons were protected from intestinal inflammation; however, mice whose intestinal viruses were replaced with viruses associated with IBD exhibited exacerbated inflammation.
“The intestinal virome is established from birth, shaped through life and includes vast numbers of known viruses and copious ‘dark matter’ we cannot yet identify,” says Jeffrey. “Our work provides a missing functional link that our collective virome is an important contributor to human health, but when perturbed does provoke inflammation in IBD and conceivably many other diseases.”
Jeffrey notes that patients with IBD might benefit from therapies that harness the virome, either through targeted elimination—with vaccines or antiviral medications—or replacement of disease-driving intestinal viruses with health-promoting viruses—such as with virome transfers, akin to fecal transfers.
Additional study authors include Fatemeh Adiliaghdam, Hajera Amatullah, Sreehaas Digumarthi, Tahnee L. Saunders, Raza-Ur Rahman, Lai Ping Wong, Ruslan Sadreyev, Lindsay Droit, Jean Paquette, Philippe Goyette, John Rioux, Richard Hodin, Kathie A. Mihindukulasuriya, and Scott A. Handley.
This work was supported by the Kenneth Rainin Foundation, Harvard Catalyst, the National Institutes of Health, and the MGH Research Scholar initiative.
About the Massachusetts General Hospital
Massachusetts General Hospital, founded in 1811, is the original and largest teaching hospital of Harvard Medical School. The Mass General Research Institute conducts the largest hospital-based research program in the nation, with annual research operations of more than $1 billion and comprises more than 9,500 researchers working across more than 30 institutes, centers and departments. In August 2021, Mass General was named #5 in the U.S. News & World Report list of "America’s Best Hospitals." MGH is a founding member of the Mass General Brigham healthcare system.