Explore This Lab

Overview

Andrea Edlow, MD, MsC, is a member of the Obstetrics and Gynecology Faculty at Harvard Medical School and a Maternal-Fetal Medicine specialist at Massachusetts General Hospital.

The laboratory of Andrea Edlow, MD, MSc, at Massachusetts General Hospital focuses on the effects of maternal obesity on fetal brain development and offspring behavior, and how these effects are modified by fetal sex.

Our lab was one of the first to use amniotic fluid supernatant and umbilical cord blood to investigate real-time fetal brain development in obese human pregnancy.

Gene expression profiling of these two biofluids identified abnormal gene expression signatures in fetuses of obese women, highlighting dysregulated brain development and increased inflammation.

Using a validated mouse model of maternal diet-induced obesity, we have demonstrated significant sex differences in the impact of maternal obesity on embryonic brain development, catecholamine neurotransmitter signaling, and offspring neurobehavior.

Maternal diet during pregnancy and lactation also significantly influences in utero brain development and offspring behavior.

Ultimately, we anticipate this work will provide targets for a lifestyle/behavioral intervention, and possibly for prenatal therapies that could be given orally to obese pregnant women, to reverse or ameliorate deleterious structural and functional changes.

In the News

Research reveals compromised transfer of SARS-CoV-2-specific antibodies through the placenta - Dec. 2020 - Mass General

Pregnant women with COVID-19 don’t pass virus to newborns, but also may pass fewer-than-expected antibodies to newborns - Dec. 2020 - Mass General

NORCH Newsletter Investigator Spotlight: Andrea G. Edlow, MD, MSc - Nov. 2019

Lab Members

Principal Investigator

Andrea Edlow, MD, MSc

Andrea Edlow, MD, MSc
Assistant Professor of Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School




Laboratory Staff

Lydia Shook, MD

Lydia Shook, MD – Clinical/Research Fellow





Sara Brigida


Rose DeGuzman


Lab Alumni

  • Ruthy Glass, PhD, postdoctoral fellow. Current position: Associate Consultant, IQVIA
  • William Jin, BS, lab technician. Current position: Master’s student, Boston University

Publications

Selected Publications