Hepatic Artery Infusion Pump Program
Hepatic Artery Infusion Pump Program
55 Fruit Street
Boston, MA 02114
Explore This Treatment Program
About the Hepatic Artery Infusion Pump Program
The Hepatic Artery Infusion (HAI) Pump Program at Massachusetts General Hospital is a highly specialized, multidisciplinary collaboration that uses hepatic artery pumps (also known as liver chemotherapy pumps) to treat primary and metastatic tumors of the liver. The pumps are mainly used to treat unresectable, metastatic colorectal liver cancer (cancer that has spread from the colon to the liver).
Mass General is the only hospital in the region that offers hepatic artery infusion pumps as a treatment approach for liver cancer.
The hepatic artery infusion pumps are managed by a multidisciplinary team including:
- Surgeons who are specially trained to place the pump into the liver, safely and effectively
- Medical oncologists from the Mass General Cancer Center who are experts in using the pumps to administer chemotherapy
- Radiologists, including interventional radiologists and nuclear medicine doctors, who evaluate the pump for safe use and ensure that the chemotherapy is delivered only to the liver
- A multitude of highly specialized nurses and staff including infusion nurses, floor nurses, operating room staff and recovery nurses, anesthesia doctors, and pharmacy staff
Hepatic Artery Infusion Pump Treatment
When colorectal cancer metastasizes (spreads throughout the body), it frequently results in liver tumors. Patients with primary or metastatic tumors that cannot be removed because of their location or size (unresectable tumors) may be able to undergo hepatic artery infusion pump placement, which infuses high doses of chemotherapy directly into the liver to shrink them to the point that they can be surgically resected. These pumps allow for the chemotherapy (Floxuridine) to specifically target the tumor through the hepatic artery, a blood vessel that goes to the liver, so that medication remains in the liver and does not spill out to other organs in the body. The healthy parts of the liver continue to receive the blood supply from a separate blood vessel, the portal vein, which is not impacted by HAI therapy.
Treatment with HAI therapy can also be used after liver surgery as a way to prevent recurrence of cancer within the liver.
Mass General surgeons surgically place the pump into the abdominal wall and insert a small, flexible tube into the hepatic artery to transfer high doses of chemotherapy directly into the liver and target the tumors.
Hepatic Artery Infusion Pump Vs. Traditional Chemotherapy
Traditional chemotherapy methods inject medication by vein (intravenously), which causes it to circulate throughout the entire body before it reaches the cancer. With the hepatic artery pump, a much higher and more concentrated amount is administered directly into the cancerous area where it is rapidly metabolized, resulting in limited toxicity to the rest of the body. These treatments can be used simultaneously in centers of excellence and expertise, such as Mass General Cancer Center.
The pump is effective in:
- Shrinking large tumors so that they can be surgically removed in the future
- Delaying or preventing the growth of additional tumors in the liver
Recovery After Hepatic Artery Infusion Pump Placement
The hepatic artery pump is surgically placed in an inpatient procedure that can last up to three hours. A specialized nuclear medicine scan ensures that the pump is placed in the appropriate position to prevent chemotherapy from traveling to organs outside of the liver (extrahepatic perfusion).
Patients can expect to recover at the hospital for a few days after surgery, where they will be cared for by the perioperative care team. At home, only light activity is recommended, as it may take an additional four weeks to fully recover from surgery. The pump is designed to release medication at a set rate for a period of time.
Patients can expect to return to the hospital for recurring follow-up visits to assess the progress of their condition, refill and flush their pump, and further discuss the treatment plan. The timeline for follow-up visits is determined by the specialized care team.
Improving Outcomes for Liver Cancer
As an academic medical center, Mass General invests in research and clinical trials to better understand liver diseases and develop innovative approaches to prevention and treatment. Notably, Mass General participates in a national consortium called the U.S. HAI Consortium that leads collaborative studies to demonstrate the hepatic artery infusion pump’s effectiveness, improve upon the procedure and its outcomes, and increase access for qualifying patients to receive care.
- Qadan M, Ryan DP. Hepatic arterial infusion pump: Quo Vadis? Ann Surg 2022; 276: 957-958
- Qadan M, D’Angelica MI, Kemeny NN, Cercek A, Kingham TP. Robotic hepatic arterial infusion pump placement. HPB (Oxford) 2017; 19: 429-435
- Groot Koerkamp B, Sadot E, Kemeny NE, Gönen M, Leal JN, Allen PJ, Cercek A, DeMatteo RP, Kingham TP, Jarnagin WR, D'Angelica MI. Perioperative hepatic arterial infusion pump chemotherapy is associated with linger survival after resection of colorectal liver metastases: A propensity score analysis. J Clin Oncol 2017; 35: 1938-1944
- Qadan M, Kemeny NE. Regional chemotherapy for liver tumors. Blumgart’s Surgery of the Liver, Biliary Tract, and Pancreas. 6th Edition. By William Jarnagin. Philadelphia, PA. Elsevier Mosby 2016
- Qadan M, D’Angelica MI. Complex surgical strategies to improve resectability in borderline-resectable disease. Curr Colorectal Cancer Rep 2015; 11: 369-377
- McAuliffe JC, Qadan M, D’Angelica MI. Hepatic resection, hepatic arterial infusion pump therapy, and genetic biomarkers in the management of hepatic metastases from colorectal cancer. J Gastrointest Oncol 2015; 6: 699-708
- DʼAngelica MI, Correa-Gallego C, Paty PB, Cercek A, Gewirtz AN, Chou JF, Capanu M, Kingham TP, Fong Y, DeMatteo RP, Allen PJ, Jarnagin WR, Kemeny N. Phase II trial of hepatic artery infusion and systemic chemotherapy for patients with unresectable hepatic metastases from colorectal cancer: Conversion to resection and long-term outcomes. Ann Surg 2015; 261: 353-360
- Kemeny N, Huang Y, Cohen AM, Shi W, Conti JA, Brennan MF, Bertino JR, Turnbull AD, Sullivan D, Stockman J, Blumgart LH, Fong Y. Hepatic arterial infusion of chemotherapy after resection of hepatic metastases from colorectal cancer. New Engl J Med 1999; 341: 2039-2048
Frequently Asked Questions
How do I make an appointment for this treatment?
How does hepatic artery infusion work?
What are the benefits of the hepatic artery pump vs. traditional chemotherapy?
Am I eligible for a hepatic artery infusion pump?
How often will I need to see my doctor after the pump has been implanted?
Do I have to limit my activities during HAI therapy?
Liver Cancer Treatment
Learn about Mass General Cancer Center’s expert approach to liver cancer treatment.
Preparing for Surgery
Review information and instructions to help you prepare for your surgery or procedure.
Animation: How It Works
Watch a short animation that explains HAI therapy and how it works in the body.
- Gapontsev Family Endowed Chair in Surgical Oncology
- Associate Professor of Surgery
- Department of Medicine
- General and Gastrointestinal Surgery
- Department of Surgery
- Chief, Division of Gastrointestinal and Oncologic Surgery
- Deputy Clinical Director, MGH Cancer Center
- Director, Clinical Trials Support
- Department of Medicine
- Chief, Hematology/Oncology
- Clinical Director, Mass General Cancer Center
- Chief, Division of Interventional Radiology
Nurse Practitioner and Clinical Nurse Specialists
- Christian Baglini, NP
- Andrea Hansen, RN
- Kendra Connelly, RN
- Christina Chio, PharmD, BCOP
- Karie LaFleur, PharmD
- Katharine Hanger, PharmD
Mass General Cancer Center
Every single day at the Mass General Cancer Center we're finding new ways to treat and manage cancer.
Preparing for Surgery
Learn more about what to expect as your surgery approaches and how you can best prepare yourself for it.
Liver Care During COVID-19
Even during COVID-19, diseases and masses of the liver are important health concerns and it’s important seek care.
Request an Appointment or Referral
Patients and referring providers can request an appointment with the Hepatic Artery Pump Program team by phone.