Explore the Center

About the Center

The Vocal Hyperfunction Clinical Research Center (VHCRC) at Massachusetts General Hospital is a comprehensive, multi-institutional research program that brings together a multidisciplinary team of investigators with various specialties to study hyperfunctional voice disorders. The VHCRC is led by Robert Hillman, PhD, CCC-SLP, research director and co-director of the Mass General Voice Center. The central theme of the VHCRC is that clinical management of VH can be significantly improved by attaining a better understanding of the multiple causative factors and associated disordered physiological processes associated with these disorders and then translating this knowledge into new, more effective methods for prevention, diagnosis and treatment.

The center’s scope of research in VH is unprecedented, especially in regards to the integration of many types of data (e.g., behavioral, sensorimotor, environmental, psychological/emotional and biomechanical data) on a large scale, across multiple institutions and areas of expertise..

About the Condition

Vocal hyperfunction (VH) is one of the most prevalent types of voice disorders and refers to chronic conditions of abuse or misuse of the vocal mechanism (larynx or voice box) due to excessive and/or unbalanced (uncoordinated) muscular forces. These voice disorders include benign vocal fold lesions on vocal cords (commonly called vocal cord nodules) and vocal deterioration in the absence of diagnosable pathology (commonly called muscle tension dysphonia).

Scientific Premise

Multiple factors are believed to cause and maintain the disorders linked to VH. The most important mechanisms include:

  • Behavioral
  • Biomechanical
  • Emotional
  • Environmental
  • Psychological
  • Sensorimotor

VHCRC’s interdisciplinary research program will focus on understanding the fundamental relationships between these factors and the different manifestations of VH. This will be accomplished in three major research projects led by Dr. Hillman, Cara Stepp, PhD, and Matías Zañartu, PhD, and a scientific core led by Daryush Mehta, PhD. They will employ an innovative combination of laboratory studies of sensorimotor and physiological mechanisms; neural network modeling of voice motor control; computational and physical modeling of phonatory mechanisms; and the use of ambulatory biosensors to investigate the potential differential impact on vocal function of daily voice use, psychological stress and environmental noise in patients with VH and well-matched normal controls. Use of ambulatory biofeedback as a treatment strategy will also be assessed.

Goals

  • To better delineate the etiological and pathophysiological mechanisms that underlie the range of voice disorders associated with VH
  • To develop more specific and accurate classification or phenotyping of VH based on solid scientific evidence of disparate underlying etiological and pathophysiological mechanisms
  • To use the new information about mechanisms of VH to develop and test new clinical methods to improve the prevention, differential diagnosis, and targeted behavioral treatment of hyperfunctional voice disorders

Vocal Hyperfunction Theoretical Framework (PDF)

Acknowledgments: The VHCRC is supported by funding from the National Institutes of Health National Institute on Deafness and Other Communication Disorders through Grant P50 DC015446. Website content is solely the responsibility of the investigators and does not necessarily represent the official views of the National Institutes of Health.

Research Projects

The below three research projects focus on investigating mechanisms that are hypothesized to play primary roles in causing and/or maintaining Vocal Hyperfunction (VH). Expand each title to learn more.

Use of ambulatory biosensors to improve the differential diagnosis and treatment of vocal hyperfunction

Principal Investigator: Robert E. Hillman, PhD, CCC-SLP, Mass General

This project uses an innovative combination of ambulatory biosensors, clinical and laboratory studies, and tracking of treatment-related effects to gain new insights into behavioral (daily voice use), environmental (noise levels), emotional (psychological stress/arousal), and physiological (phonatory function) factors related to the etiology and pathophysiology of VH. Researchers will assess the assumed role of emotional stress in eliciting a differential VH response in patients with hyperfunctional voice disorders and normal controls. In a secondary analysis, the team will examine the hypothesized impact of personality and psychological predisposition (trait theory) in modulating the vocal/VH response to emotional stress by having participants complete personality inventories. A major thrust of this project will involve testing hypotheses about the differential impact of VH on the phonatory physiology (biomechanics) associated with phonotraumatic VH (e.g., nodules) and nonphonotraumatic VH (e.g., muscle tension dysphonia). This will also include investigating the potential modulating impact on VH of environmental noise levels (Lombard Effect – increasing vocal SPL) and the presence of nodules (e.g., testing hypotheses related to the need for post-surgical voice therapy to reduce persistent/residual phonotraumatic VH). Special emphasis will be placed on testing biomechanics-based hypotheses related to the role of collision forces in phonotraumatic VH. Use of ambulatory biofeedback as a treatment strategy will also be assessed.

Sensorimotor mechanisms of vocal hyperfunction

Principal Investigator: Cara E. Stepp, PhD, Boston University

This project uses classic model-driven experimental approaches from speech motor control research to test hypotheses concerning the potential role that disordered sensorimotor mechanisms play in VH. Auditory-motor integration for feedforward and feedback control are examined. These studies include the potential impact that voice therapy might have in reducing such deficits by triggering neuroplastic central nervous system changes. This project will rely on ambulatory measures that are being further refined in Project 1 to assess pre- and post-treatment changes in daily vocal function.

Modeling biomechanical and aero-acoustic mechanisms of vocal hyperfunction

Principal Investigator: Matías Zañartu, PhD, Universidad Técnica Federico Santa María

This project develops and uses physical and numerical modeling (including subject-specific models) to provide unique insights into the underlying biomechanical, aero-acoustic, and muscle activation mechanisms that contribute to the pathophysiology of VH, providing direct links between model outputs and real clinical data with direct application to the ambulatory assessment of vocal function. This important fundamental work closely links/integrates with Projects 1 and 2 by providing unique insights into these mechanisms that cannot be obtained with current approaches and, in the case of Project 1, extending or improving ambulatory assessment of daily vocal function for clinical evaluation and treatment (biofeedback).



Publications

Expand the below categories to view a sampling of our work, all of which is supported by clinical research center funding.

Publications
  1. M. Diaz-Cadiz, S. D. Peterson, G.E. Galindo, V. M. Espinoza, M. Motie-Shirazi, B. D. Erath, M. Zañartu. “Estimating Vocal Fold Contact Pressure from Raw Laryngeal High-Speed Videoendoscopy Using a Hertz Contact Model,” Applied Sciences. 9(11), pp. 2384. link pdf
  2. Cortés J.P., Alzamendi G., Weinstein A., Yuz J., Espinoza V. M., Mehta D., Van Stan J., Hillman R., Zañartu M. “Kalman Filter Implementation of the Subglottal Impedance-Based Inverse Filtering Scheme and its Application for Assessing Model Uncertainty,” in review in the IEEE Journal of Selected Topics in Signal Processing (2019).
  3. Deng J.J., Hadwin P.J., Peterson, S.D. "The Effect of High-Speed Videoendoscopy Configuration on Reduced-Order Model Parameter Estimates by Bayesian Inference," in review in The Journal of the Acoustical Society of America (2019).
  4. Díaz-Cádiz M., Peterson S.D., Galindo G.E., Espinoza V.M., Motie-Shirazi M., Erath B.D., Zañartu M. “Estimating Vocal Fold Contact Pressure from Raw Laryngeal High-Speed Videoendoscopy Using a Hertz Contact Model,” Applied Sciences, 9(11), pp. 2384; https://doi.org/10.3390/app9112384.
  5. Erath B.D., Peterson S.D., Weiland K.S., Plesniak M.W., Zañartu M. “An acoustic source model for asymmetric intraglottal flow with application to reduced-order models of the vocal folds,” in review in PLOS ONE (2019).
  6. Hadwin P.J., Motie-Shirazi M., Erath B.D., Peterson, S.D. "Bayesian Inference of Vocal Fold Material Properties from Glottal Area Waveforms using a 2D Finite Element Model," in review in Applied Sciences(2019).Kearney E., Nieto-Castanon A., Weerathunge H.R., Falsini R., Daliri A., Abur D., Ballard K.J., Chao S., Heller Murray E.S., Scott T.L., Guenther F.H. “A Simple 3-Parameter Model for Examining Adaptation in Speech and Voice Production,” in review in Frontiers in Psychology (2019).
  7. Lin J.Z., Espinoza V.M., Marks K.L., Zañartu M., Mehta D.D. “Improved Subglottal Pressure Estimation from Neck-Surface Vibration in Healthy Speakers Producing Non-Modal Phonation,” in review in the IEEE Journal of Selected Topics in Signal Processing (2019).
  8. Marks K.L., Lin J.Z., Fox A., Toles L.E., Mehta D.D. “Impact of Non-Modal Phonation on Estimates of Subglottal Pressure from Neck-Surface Acceleration in Healthy Speakers,” in review in the Journal of Speech, Language, and Hearing Research (2019).
  9. Mehta D.D., Kobler J.B., Zañartu M., Erath B.D., Motie-Shirazi M., Peterson S.D., Petrillo R.H., Hillman R.E. “Toward Development of a Vocal Fold Contact Pressure Probe: Dual-Sensor Probe Validation Using Excised Human Larynx Models,” in review in Applied Sciences (2019).
  10. Motie-Shirazi M., Zañartu M., Peterson S.D., Mehta D.D., Kobler J., Hillman R.E., Erath B.D. “Toward Development of a Vocal Fold Contact Pressure Probe: Sensor Characterization and Validation Using Synthetic Vocal Fold Models,” in review in Applied Sciences (2019).
  11. Ortiz A.J., Toles L.E., Marks K.L., Capobianco S., Mehta D.D., Hillman R.E., Van Stan J.H. “Automatic Speech and Singing Classification in Ambulatory Recordings for Normal and Disordered Voices,” in review in The Journal of the Acoustical Society of America (2019).
  12. Van Stan J.H., Mehta D.D., Ortiz A.J., Burns J.A., Toles L.E., Marks K.E., Vangel M., Hron T., Zeitels S., Hillman, R.E. “Differences in Daily Vocal Behavior Between Patients with Phonotraumatic Lesions and Matched Healthy Controls,” in review in the Journal of Speech Language and Hearing Research (2019).
  13. Heller Murray E., Lupiani A., Kolin K., Segina R., Stepp C. (2019) “Pitch Shifting with the Commercially Available Eventide Eclipse: Intended and Unintended Changes to the Speech Signal,” Journal of Speech, Language, and Hearing Research (in press).
  14. Mucarquer J.A., Prado P., Escobar M.J., El-Deredy W., Zañartu M. (2019) “Improving EEG Muscle Artifact Removal with an EMG Array,” IEEE Transactions on Instrumentation and Measurement (in press).
  15. Prado P., Otero M., Martínez-Montes E., Weinstein A., Escobar M.J., El-Deredy W., Zañartu M. (2019) “A Method for Tracking the Time Evolution of Steady-State Responses,” Journal of Visualized Experiments (in press).
  16. Ghasemzadeh H., Deliyski D.D., Ford D.S., Kobler J.B., Hillman R.E., Mehta D.D. (2019) “Method for Vertical Calibration of Laser-Projection Transnasal Fiberoptic High-Speed Videoendoscopy,” Journal of Voice (in press). Winner of the Sataloff Award.
  17. Ciccarelli G., Mehta D., Ortiz A., Van Stan J., Toles L., Marks K., Hillman R., Quatieri T. (2019) “Correlating an Ambulatory Voice Measure to Electrodermal Activity in Patients with Vocal Hyperfunction,” Proceedings of the 16th International Conference on Wearable and Implantable Body Sensor Networks, 4 pages.
  18. Manriquez R., Peterson S.D., Prado P., Orio P., Galindo G.E., Zañartu M. (2019) “Neurophysiological Muscle Activation Scheme for Controlling Vocal Fold Models,” IEEE Transactions on Neural Systems and Rehabilitation Engineering, 27(5):1043–1052.
  19. Mehta D.D., Espinoza V.M., Van Stan J.H., Zañartu M., Hillman R.E. (2019) “The Difference Between First and Second Harmonic Amplitudes Correlates Between Glottal Airflow and Neck-Surface Accelerometer Signals During Phonation,” The Journal of the Acoustical Society of America, 145(5):EL386–EL392.
  20. Murton O., Shattuck-Hufnagel S., Choi J.Y., Mehta D.D. (2019) “Identifying a Creak Probability Threshold for an Irregular Pitch Period Detection Algorithm,” The Journal of the Acoustical Society of America, 145(5):EL379–EL385.
  21. Gonzalez Ortiz J.J., Guttag J., Hillman R.E., Mehta D., Van Stan J.H., Ghassemi M. (2018) “Learning from Few subjects in the Presence of Large Amounts of Ambulatory Data,” Proceedings of the Machine Learning for Health (ML4H) Workshop at NeurIPS, 6 pages.
  22. Cortés J.P., Espinoza V.M., Ghassemi M., Mehta D.D., Van Stan J.H., Hillman R.E., Guttag J.V., Zañartu M. (2018) “Ambulatory Assessment of Phonotraumatic Vocal Hyperfunction Using Glottal Airflow Measures Estimated from Neck-Surface Acceleration,” PLOS ONE, 13(12):e0209017.
  23. Galindo G.E., Peterson S.D., Erath B.D., Castro C., Hillman R.E., Zañartu M. (2017) “Modeling the Pathophysiology of Phonotraumatic Vocal Hyperfunction With a Triangular Glottal Model of the Vocal Folds,” Journal of Speech, Language, and Hearing Research, 60(9):2452–2471.
  24. Espinoza V.M., Zañartu M., Van Stan J.H., Mehta D.D., Hillman R.E. (2017) “Glottal Aerodynamic Measures in Adult Females with Phonotraumatic and Non-Phonotraumatic Vocal Hyperfunction,” Journal of Speech, Language, and Hearing Research, 60(8):2159–2169.
Conference Abstracts
  1. A. Testart, G. Galindo, C. Castro, M. Zañartu. “A new visual probabilistic assessment of vocal fold vibration”, The 12th International Conference on Advances in Quantitative Laryngology, Voice and Speech Research, Hong Kong, October 17-21, 2017.
  2. J. P. Cortés, M. Zañartu. “Ambulatory classification of patients with muscle tension dysphonia vs. control group”, The 12th International Conference on Advances in Quantitative Laryngology, Voice and Speech Research, Hong Kong, October 17-21, 2017.
  3. R. Manrıquez, S. D Peterson, P. Prado, P. Orio, M. Zañartu, “Laryngeal muscle activation noise for physiologically-based models of phonation”, The 12th International Conference on Advances in Quantitative Laryngology, Voice and Speech Research, Hong Kong, October 17-21, 2017.
  4. R. Manrıquez, S. D Peterson, P. Prado, P. Orio, M. Zañartu, “Modeling Laryngeal Muscle Activation Noise for Low-Order Physiological Based Speech Synthesis”, Proc. Interspeech 2017, pp 1378- 1382, Stockholm, Sweden, August 2017 
  5. V. M. Espinoza, M. Zañartu, J. H. Van Stan, D. D. Mehta, and R. E. Hillman  “Uncertainty of glottal airflow estimation during continuous speech using impedance-based inverse filtering of the neck-surface acceleration signal”, Fall 2017 meeting of the ASA, Boston, USA, June 25-29, 2017. 
  6. Mehta D. D., Van Stan J. H., Masson M. L. V., Maffei M., Hillman R. E. Relating ambulatory voice measures with self-ratings of vocal fatigue in individuals with phonotraumatic vocal hyperfunction. Proceedings of the Acoustical Society of America 2017.
  7. Cortés J. P., Zañartu M., Mehta D. D., Van Stan J. H., Hillman R. E. Classification of patients with muscle tension dysphonia and matched-controls using ambulatory voice monitoring. Proceedings of the International Conference on Advances in Quantitative Laryngology, Voice and Speech Research 2017.
  8. Capobianco S., Ruggles R., Ortiz A. J., Mehta D. D., Hillman R. E., Van Stan J. H. Automatic classification of speech and singing during ambulatory voice monitoring using a neck-placed accelerometer. Proceedings of La Voce Artistica 2017.
  9. J.P. Cortes, V. M. Espinoza, M. Ghassemi, D. Mehta, J. Van Stan, R. Hillman, J. Guttag, M. Zañartu, “Using Aerodynamic Features and Their Uncertainty for the Ambulatory Assessment of Phonotraumatic Vocal Hyperfunction” IEEE International Conference on Biomedical and Health Informatics, March 4-7, 2018 in Las Vegas, NV.
  10. Brockmann-Bauser M., Van Stan J. H., Bohlender J. E., Mehta D. D. Acoustic-based cepstral peak prominence and spectral slope improve with increasing vocal intensity in women with and without voice disorders. Proceedings of the 12th Congress of the European Laryngological Society (ELS) 2018; London, England.
  11. Brockmann-Bauser M., Van Stan J. H., Bohlender JE, Mehta D. D. Effect of vocal intensity on cepstral peak prominence and spectral slope in women with and without voice disorders. Proceedings of the Voice Foundation Symposium 2018; Philadelphia, PA.
  12. Marks K. L. and Mehta D. D. Impact of non-modal phonation on estimates of subglottal pressure from neck-surface acceleration in healthy speakers. Proceedings of the Voice Foundation Symposium 2018; Philadelphia, PA.
  13. Van Stan J. H., Capobianco S., Ruggles R. K., Ortiz A. J., Toles L. E., Marks K. L., Hillman R. E., Mehta D. D. Ambulatory voice measures during singing and speech in patients with phonotraumatic vocal fold lesions compared to matched controls. Proceedings of the Voice Foundation Symposium 2018; Philadelphia, PA.
  14. Ghasemzadeh H., Naghibolhosseini M., Mehta D. D., Deliyski D. D. Machine-learning approach for automatic detection of calibrated laser light in transnasal flexible high-speed videoendoscopy. Proceedings of the Voice Foundation Symposium 2018; Philadelphia, PA.
  15. Deliyski D., Mehta D. D., Zañartu M., Shishkov M., Bouma B., de Alarcón A., Ghasemzadeh H., Hillman R. E. Laser-calibrated system for laryngeal transnasal flexible high-speed videoendoscopy. Proceedings of the Voice Foundation Symposium 2018; Philadelphia, PA.
  16. Brockmann-Bauser M., Van Stan J., Bohlender J. E., Mehta D. D. Spectral acoustic measures improve with increasing vocal intensity. Proceedings of the 29thth Congress of Union of the European Phoniatricians (UEP) 2018; Helsinki, Finland.
  17. P.  Prado, C. Christian, A. Weinstein, L. Zepeda, M. Zañartu,  “Cortical activation of healthy volunteers and muscle tension dysphonia (MTD) patients during Lombard Effect: an EEG study”, Joint meeting of the Chilean Societies of Biology, Genetics, Evolution, and Neuroscience, November 20-22, Puerto Varas, Chile, 2018.
  18. Hadwin, P. J. and Peterson, S. D., "Bayesian Inference of Tissue Properties from Glottal Area Waveforms Using a 2D Finite Element Model," 176th Meeting of the Acoustical Society of America, Victoria, BC, November 5-9, 2018.
  19. M. Diaz, M. Zañartu, C. Stepp, “How to construct your own high-speed flexible video endoscopy system for research and clinical applications”, The Fall Voice Conference 2018, October 25-27, Seattle, Washington, 2018.
  20. Park Y., Stepp C. E. “Do people who have breathier voices perceive breathiness differently?,” The Fall Voice Conference, Seattle, WA, October 25 – October 27, 2018. [poster presentation]
  21. Heller Murray E. S., Kolin K. R., Harvey Woodnorth G., Stepp C. E. “Relative Fundamental Frequency in Children With and Without Vocal Fold Nodules”, American Speech and Hearing Association (ASHA) Convention, Boston, MA, November 15-17, 2018. [podium presentation]
  22. V. Espinoza, D. Mehta, J. VanStan, R. E. Hillman, M. Zañartu, “Accelerometer-based aerodynamic measures for subjects with phonotraumatic hyperfunction: An in-laboratory study”, 11th International Conference on Voice Physiology and Biomechanics, August 1-3, 2018, East Lansing, Michigan.
  23. Heller Murray E.S., Lupiani A.A., Kolin K.R., Stepp C.E. “Accuracy of the commercially available Eventide Eclipse to perturb Auditory feedback of fundamental frequency”, 11th International Conference on Voice Physiology and Biomechanics, East Lansing, MI, August 1 – 3, 2018. [poster presentation] 
  24. C. Castro, P. Prado, D. Marfull, A. Testart, A. Weinstein, L. Zepeda, V. Espinoza, M. Zañartu, “Lombard effect and muscle tension dysphonia: acoustic, aerodynamic, biomechanical and cortical changes”, 11th International Conference on Voice Physiology and Biomechanics, August 1-3, 2018, East Lansing, Michigan.
  25. J.P. Cortés, V. M. Espinoza, M. Ghassemi, D. Mehta, J. Van Stan, R. Hillman, J. Guttag, M. Zañartu, “Aerodynamic Ambulatory Assessment for Phonotraumatic Vocal Hyperfunction”, 11th International Conference on Voice Physiology and Biomechanics, August 1-3, 2018, East Lansing, Michigan.
  26. Deng, J., Hadwin, P. J. and Peterson, S. D., “The Influence of High-Speed Videoendoscopy Data Quality on Reduced-Order Model Parameters Estimated Using Bayesian Inference," 11th International Conference on Voice Physiology and Biomechanics, East Lansing, MI, August 1-3, 2018.
  27. M. Motie-Shirazi, B. D. Erath. “The effect of a posterior glottal gap on contact pressures in a synthetic self-oscillating vocal fold model,” 11th International Conference on Voice Physiology and Biomechanics, East Lansing, MI July 31-August 3, 2018.
  28. Mehta D., Kobler J., Zeitels S., Hillman R. In vivo probe for tracking intraglottal pressure, vocal fold collision, and subglottal pressure during phonation. Proceedings of the 11th International Conference on Voice Physiology and Biomechanics 2018; East Lansing, MI.
  29. Mehta D. D., Van Stan J. H., Hillman R. E. Toward objective ambulatory measures of vocal status in patients with vocal hyperfunction. Proceedings of the 11th International Conference on Voice Physiology and Biomechanics 2018; East Lansing, MI.
  30. Toles L., Ortiz A. J., Mehta D. D., Hillman R. E., Van Stan J. H. Speech and singing detection in ambulatory voice recordings in patients with phonotraumatic lesions and controls. Proceedings of the Annual Convention of the American Speech-Language-Hearing Association 2018; Boston, MA.
  31. Marks K, Lin J. Z., Mehta D. D. Estimating subglottal pressure from anterior neck-surface acceleration in patients with voice disorders. Proceedings of the Annual Convention of the American Speech-Language-Hearing Association 2018; Boston, MA.
  32. Hylkema J., McKenna V. S., Stepp C. E. “Voice Onset Time in Individuals with Hyperfunctional Voice Disorders”, American Speech and Hearing Association (ASHA) Convention, Boston, MA, November 15-17, 2018. [poster presentation]
  33. Mehta D. D., Whittico T. H., Ortiz A. J., Marks K. L., Toles L. E., Van Stan J. H., Hillman RE. Investigating ambulatory Lombard effects during the daily life of patients with phonotraumatic vocal hyperfunction. Proceedings of the Occupational Voice Symposium 2019; London, UK.
  34. Van Stan J. H., Stadelman-Cohn T., Muise J., Krusemark C., Ortiz A. J., Mehta D. D., Burns J. A., Hron T. A., Hillman R. E. Personalized ambulatory biofeedback for patients with vocal hyperfunction. Proceedings of the Occupational Voice Symposium 2019; London, UK.
  35. Ghasemzadeh H., Ford D. S., Deliyski D. D., Kobler J. B., Hillman R. E., Mehta D. D. Calibration method for laser-projection transnasal flexible high-speed videoendoscopy. Proceedings of the Voice Foundation Symposium 2019; Philadelphia, PA. Received Sataloff Award.
  36. Gabriel A. Alzamendi, Christian Castro Toro, Sean D. Peterson, Byron D. Erath, Matías Zañartu, “Modeling Modal, Breathy, and Pressed Voice Qualities: The Role of Intrinsic Laryngeal Muscle Activation”, 48th Voice Foundation Annual Symposium: Care of the Professional Voice, Philadelphia, Pennsylvania, May 29 - June 2, 2019.
  37. Juan Pablo Cortés, Víctor M. Espinoza, Christian Castro Toro, Rodrigo Manríquez Peralta, Alba Testart Tobar, Matías Zañartu, “Classification Performance of Paired Subjects with Vocal Hyperfunction in the Presence of Subglottal Inverse Filtering Uncertainties: Pilot Study under Laboratory Conditions”, 48th Voice Foundation Annual Symposium: Care of the Professional Voice, Philadelphia, Pennsylvania, May 29 - June 2, 2019.
  38. Pavel Prado, Álvaro Cavieres, Lucia Zepeda, Alejandro Weinstein, Matías Zañartu, Sonja Kotz, Wael El-Deredy, “Understanding Cortical Activation Associated with Corollary Discharge during Speech Production: The Role of Active and Passive Listening”, 48th Voice Foundation Annual Symposium: Care of the Professional Voice, Philadelphia, Pennsylvania, May 29 - June 2, 2019.
  39. Matías Zañartu, “Estimating Vocal Fold Contact Pressure In Vivo from Raw Laryngeal High-Speed Videoendoscopy using a Hertz Contact Model”, invited talk at the special session “Quantifying Vocal Fold Contact Pressure using Direct and Indirect Measurement Modalities”, 48th Voice Foundation Annual Symposium: Care of the Professional Voice, Philadelphia, Pennsylvania, May 29 - June 2, 2019.
  40. Sean D. Peterson “Quantifying Vocal Fold Contact Pressure through Bayesian Estimation of Reduced and High-Order Vocal Fold Models”, invited talk at the special session “Quantifying Vocal Fold Contact Pressure using Direct and Indirect Measurement Modalities”, 48th Voice Foundation Annual Symposium: Care of the Professional Voice, Philadelphia, Pennsylvania, May 29 - June 2, 2019.
  41. Byron D. Erath “Quantifying Uncertainty in Contact Pressure Measurements with Synthetic, Self-Oscillating Vocal Fold Models”, invited talk at the special session “Quantifying Vocal Fold Contact Pressure using Direct and Indirect Measurement Modalities”, 48th Voice Foundation Annual Symposium: Care of the Professional Voice, Philadelphia, Pennsylvania, May 29 - June 2, 2019.
  42. Daryush D. Mehta, “Validating Vocal Fold Contact Pressure Measurement using Excised Human Larynx Models”, invited talk at the special session “Quantifying Vocal Fold Contact Pressure using Direct and Indirect Measurement Modalities”, 48th Voice Foundation Annual Symposium: Care of the Professional Voice, Philadelphia, Pennsylvania, May 29 - June 2, 2019.
  43. Deliyski D. D., Ghasemzadeh H., Ford D. S., Mehta D. D., Shishkov M., Bouma B. E., Kobler J. B., Zanartu M., de Alarcon A., Hillman R. E. Laser-projection system and method for 3D calibrated laryngeal measurements using transnasal flexible high-speed videoendoscopy. Proceedings of the International Conference on Advances in Quantitative Laryngology, Voice and Speech Research 2019.
  44. Mehta D. D., Kobler J. B., Zañartu M., Erath B. D., Motie-Shirazi M., Peterson S. D., Petrillo R. H., Hillman R. E. Vocal fold collision pressure amplitude and timing in an excised hemilarynx setup with dual high-speed videoendoscopy. Proceedings of the International Conference on Advances in Quantitative Laryngology, Voice and Speech Research 2019.
  45. Van Stan J. H., Vangel M., Mehta D. D., Ortiz A. J., Toles L. E., Marks K. L., Hillman R. E. Differences in ambulatory vocal behavior between patients with phonotraumatic lesions and matched healthy controls. Proceedings of the International Conference on Advances in Quantitative Laryngology, Voice and Speech Research 2019.
  46. Cortés J. P., Alzamendi G. A., Weinstein A, Yuz J. I., Espinoza V. M., Mehta D. D., Van Stan J. H., Hillman R. E., Zañartu M. Uncertainty of ambulatory airflow estimates and its effect on the classification of phonotraumatic vocal hyperfunction. Proceedings of the International Conference on Advances in Quantitative Laryngology, Voice and Speech Research 2019.
  47. MotieShirazi M., Peterson S. D., Zañartu M., Mehta D. D., Kobler J. B., Hillman R. E., Erath B. D. Contact pressure and length as a function of posterior glottal area: Synthetic vocal fold investigations. Proceedings of the International Conference on Advances in Quantitative Laryngology, Voice and Speech Research 2019.
  48. Lin J. Z., Espinoza V. M., Zañartu M., Marks K. L., Mehta D. D. Accelerometer-based prediction of subglottal pressure in healthy speakers producing non-modal phonation. Proceedings of the International Conference on Advances in Quantitative Laryngology, Voice and Speech Research 2019.
  49. Espinoza V. M., Mehta D. D., Van Stan J..H , Hillman R. E., Zañartu M. Comparing accelerometer and oral airflow based aerodynamic measures in patients with vocal hyperfunction. Proceedings of the International Conference on Advances in Quantitative Laryngology, Voice and Speech Research 2019.
  50. Pavel Prado, Christian Castro, Alejandro Weinstein, Lucía Zepeda, Juan Mucarquer and Matías Zañartu,” Cortical Mechanisms Controlling the Speech Production During Lombard Effect: An EEG Study.”, The 13th International Conference on Advances in Quantitative Laryngology, Voice and Speech Research, Montreal, Quebec, Canada, June 2 - 4, 2019.
  51. Jonathan Deng, Paul Hadwin, Mohsen Motie-Shirazi, Byron Erath, Matías Zañartu And Sean Peterson,” Extracting Reduced-Order Model Parameters from High-Speed Video Of Silicone Vocal Folds Using A Gradient-Based Approach”, The 13th International Conference on Advances in Quantitative Laryngology, Voice and Speech Research, Montreal, Quebec, Canada, June 2 - 4, 2019.
  52. Paul Hadwin, Mohsen Motie-Shirazi, Byron Erath, Matías Zañartu And Sean Peterson,” Estimating Patient-Specific Contact Pressures Using A Finite Element Model”, The 13th International Conference on Advances in Quantitative Laryngology, Voice and Speech Research, Montreal, Quebec, Canada, June 2 - 4, 2019.
  53. Gabriel A. Alzamendi, Sean D. Peterson, Byron Erath And Matías Zañartu, “Updated Rules for Constructing A Triangular Body-Cover Model Of The Vocal Folds From Intrinsic Laryngeal Muscle Activation”, The 13th International Conference on Advances in Quantitative Laryngology, Voice and Speech Research, Montreal, Quebec, Canada, June 2 - 4, 2019.
  54. Gabriel Alzamendi, Sean Peterson, Byron Erath And Matías Zañartu, “On the Role Of Simultaneous Observations For A Bayesian Estimation Of Subglottal Pressure And Laryngeal Muscle Activation”, The 13th International Conference on Advances in Quantitative Laryngology, Voice and Speech Research, Montreal, Quebec, Canada, June 2 - 4, 2019.
  55. Heller Murray E. S., Hseu A., Nuss R., Harvey Woodnorth G., Stepp C. E. “Auditory acuity to fundamental frequency in children with and without vocal fold nodules”, The 13th International Conference on Advances in Quantitative Laryngology, Voice and Speech Research, Montreal, Quebec, June 2 – 4, 2019. [podium presentation]

Group Members

ADMINISTRATIVE CORE (LEAD: MASS GENERAL)
Robert Hillman, PhD, CCC-SLP

Robert Hillman, PhD, CCC-SLP

Director, Vocal Hyperfunction Clinical Research Center
Co-Director and Research Director, Mass General Voice Center
Professor of Surgery, Harvard Medical School
Director of Research Programs, MGH Institute of Health Professions


Sarah DeRosa, MA

Sarah DeRosa, MA

Administrator Coordinator for Research and Speech-Language Pathology, Mass General Voice Center

SCIENTIFIC CORE (LEAD: MASS GENERAL)
Daryush Mehta, PhD

Daryush Mehta, PhD

Principal Investigator, Scientific Core, Vocal Hyperfunction Clinical Research Center at Mass General
Director, Voice Science and Technology Laboratory, Mass General Voice Center
Assistant Investigator, Mass General; Assistant Professor of Surgery, Harvard Medical School
Adjunct Assistant Professor, MGH Institute of Health Professions


James Burns, MD

James Burns, MD

Associate Visiting Surgeon, Mass General Voice Center
Associate Professor in Surgery, Harvard Medical School
Co-Director, Center for Laryngeal Surgery Fellowship Program


Harold Cheyne II, PhD

Harold Cheyne II, PhD

Manager of Acoustics Systems Engineering, Cirrus Logic



Gregory Ciccarelli, PhD

Gregory Ciccarelli, PhD

Technical Staff, Bioengineering Systems and Technology Group, MIT Lincoln Laboratory


Tiffiny A. Hron, MD

Tiffiny A. Hron, MD

Laryngeal Surgeon, Mass General Voice Center



Annie B. Fox

Annie B. Fox

Assistant Professor, MGH Institute of Health Professions



Andrew Ortiz, MS

Andrew Ortiz, MS

Research Engineer, Mass General Voice Center



Rob Petit

Rob Petit

Software Developer, Consultant



Thomas Quatieri, PhD

Thomas Quatieri, PhD

Senior Staff, Bioengineering Systems and Technology Group, MIT Lincoln Laboratory



Mark Vangel, PhD

Mark Vangel, PhD

Statistician, Mass General Hospital
Assistant Professor in Radiology, Harvard Medical School
Biostatistician, General Clinical Research Center, Massachusetts Institute of Technology


Jarrad Van Stan, PhD, CCC-SLP

Jarrad Van Stan, PhD, CCC-SLP

Research Speech-Language Pathologist, Mass General Voice Center
Instructor in Surgery, Harvard Medical School
Adjunct Assistant Professor, MGH Institute of Health Professions


David Viggiano

David Viggiano

Software Developer, Consultant



PROJECT 1 (LEAD: MASS GENERAL)
Robert Hillman, PhD, CCC-SLP

Robert Hillman, PhD, CCC-SLP

Director, Vocal Hyperfunction Clinical Research Center; Principal Investigator, Project 1
Co-Director and Research Director, Mass General Voice Center
Professor of Surgery, Harvard Medical School
Director of Research Programs, MGH Institute of Health Professions


Steven Zeitels, MD, FACS

Steven Zeitels, MD, FACS

Director of the Mass General Voice Center

Eugene B. Casey Professor of Laryngeal Surgery, Harvard Medical School


Jarrad Van Stan, PhD, CCC-SLP

Allison Aaron

MS Student, Speech-Language Pathology, MGH Institute of Health Professions



>Dimitar Deliyski, PhD

Dimitar Deliyski, PhD

MSU Foundation Professor and Department Chair, Michigan State University



John Guttag, PhD

John Guttag, PhD

Dugald C. Jackson Professor of Computer Science and Electrical Engineering, Massachusetts Institute of Technology



Chuanbing Huo

Chuanbing Huo

MS Student, Speech-Language Pathology, MGH Institute of Health Professions



Samantha Kridgen

Samantha Kridgen

MS Student, Speech-Language Pathology, MGH Institute of Health Professions



Katherine Marks, MS, CCC-SLP

Katherine Marks, MS, CCC-SLP

Research Speech Language Pathologist, Mass General Voice Center

PhD Student, MGH Institute of Health Professions


Daryush Mehta, PhD

Daryush Mehta, PhD

Director, Voice Science and Technology Laboratory, Mass General Voice Center

Assistant Investigator, Mass General; Assistant Professor of Surgery, Harvard Medical School

Adjunct Assistant Professor, MGH Institute of Health Professions


Nelson Roy, PhD

Nelson Roy, PhD

Professor of Communication Science and Disorder, University of Utah



Joseph Stemple, PhD

Joseph Stemple, PhD

Professor of Rehabilitation Science and Otolaryngology, University of Kentucky

Co-Director, Laryngeal and Speech Dynamics Laboratory, University of Kentucky


>Dagmar Sternad, PhD

Dagmar Sternad, PhD

Professor of Biology, Electrical and Computer Engineering, and Physics, Northeastern University



Laura Toles, MS, CCC-SLP

Laura Toles, MS, CCC-SLP

Research Speech Language Pathologist, Mass General Voice Center

PhD Student, MGH Institute of Health Professions


Jarrad Van Stan, PhD, CCC-SLP

Jarrad Van Stan, PhD, CCC-SLP

Research Speech-Language Pathologist, Mass General Voice Center

Instructor in Surgery, Harvard Medical School

Adjunct Assistant Professor, MGH Institute of Health Professions


Thomas Whittico

Thomas Whittico

MS Student, Speech-Language Pathology, MGH Institute of Health Professions



Oliver Saunders Wilder, PhD

Oliver Saunders Wilder, PhD

Post-Doctoral Fellow, Media Lab and Simons Center for the Social Brain, Massachusetts Institute of Technology


PROJECT 2 (LEAD: BOSTON UNIVERSITY)
Cara Stepp, PhD

Cara Stepp, PhD

Principal Investigator, Project 2, Vocal Hyperfunction Clinical Research Center at Mass General
Director, Sensorimotor Rehabilitation Engineering Lab, Boston University
Associate Professor, Departments of Speech, Language & Hearing Sciences, Otolaryngology-Head & Neck Surgery, and Biomedical Engineering, Boston University


Defne Abur, BS

Defne Abur, BS

PhD Student, Sensorimotor Rehabilitation Engineering Lab, Department of Speech, Language, and Hearing Sciences, Boston University


Manuel Diaz Cadiz, MS

Manuel Diaz Cadiz, MS

Research Fellow, Sensorimotor Rehabilitation Engineering Lab, Department of Speech, Language, and Hearing Sciences, Boston University


Frank Guenther, PhD

Frank Guenther, PhD

Professor, Department of Speech, Language & Hearing Sciences, Boston University

Professor, Department of Biomedical Engineering, Boston University


Elizabeth Heller Murray, MS, CCC-SLP

Elizabeth Heller Murray, MS, CCC-SLP

PhD Student, Sensorimotor Rehabilitation Engineering Lab, Department of Speech, Language, and Hearing Sciences, Boston University


J. Pieter Noordzij, MD

J. Pieter Noordzij, MD

Professor, Otolaryngology-Head & Neck Surgery, Boston University School of Medicine



Yeonggwang Park, BA

Yeonggwang Park, BA

PhD Student, Sensorimotor Rehabilitation Engineering Lab, Department of Speech, Language, and Hearing Sciences, Boston University


Joseph Perkell, PhD, DDS

Joseph Perkell, PhD, DDS

Senior Research Scientist, Department of Speech, Language & Hearing Sciences, Sargent College, Boston University


PROJECT 3 (LEAD: UNIVERSIDAD TECNICA FEDERICO SANTA MARIA)
Matias Zanartu, PhD

Matias Zanartu, PhD

Principal Investigator, Project 3, Vocal Hyperfunction Clinical Research Center at Mass General
Associate Professor, Department of Electronic Engineering, Universidad Técnica Federico Santa María


Gabriel Alzamendi, PhD

Gabriel Alzamendi, PhD

Post-Doctoral Research Associate, Department of Electronic Engineering, Universidad Técnica Federico Santa María



Byron Erath, PhD

Byron Erath, PhD

Assistant Professor, Department of Mechanical and Aeronautical Engineering, Clarkson University



Sean Peterson, PhD

Sean Peterson, PhD

Assistant Professor, Department of Mechanical and Mechatronics Engineering, University of Waterloo



Christian Castro, SLP

Christian Castro, SLP

Research Staff, Department of Electronic Engineering, Universidad Técnica Federico Santa María



Jhosmary Cuadros

Jhosmary Cuadros, MS

PhD Student, Department of Electronic Engineering, Universidad Técnica Federico Santa María



Juan Pablo Cortes

Juan Pablo Cortes, MS

PhD Student, Department of Electronic Engineering, Universidad Técnica Federico Santa María



Victor Espinoza

Victor Espinoza, PhD

Research Staff, Department of Electronic Engineering, Universidad Técnica Federico Santa María



Gabriel Galindo, PhD

Gabriel Galindo, PhD

Post-Doctoral Research Associate, Department of Electronic Engineering, Universidad Técnica Federico Santa María



Rodrigo Manriquez

Rodrigo Manriquez, MS

Research Staff, Department of Electronic Engineering, Universidad Técnica Federico Santa María



Juan Mucarquer

Juan Mucarquer, MS

MS Student, Department of Electronic Engineering, Universidad Técnica Federico Santa María



Pavel Prado, PhD

Pavel Prado, PhD

Post-Doctoral Research Associate, Advanced Center for Electrical and Electronic Engineering, Universidad Técnica Federico Santa María


Juan Yuz, PhD

Juan Yuz, PhD

Associate Professor, Department of Electronic Engineering, Universidad Técnica Federico Santa María



Lucia Zepeda

Lucia Zepeda

MS Student, Department of Biomedical Engineering, Universidad de Valparaíso