Immunotherapy is a cancer treatment that works by boosting the body’s immune system. Some patients achieve full remission, meaning all signs of their cancer have disappeared. However, these patients can potentially have serious side effects called immune-related adverse events (inAEs), which can affect almost any organ. In this Massachusetts General Hospital Blum Center presentation from July 8, 2021, Dr. Kerry Reynolds provides an immunotherapy overview. She also discusses the urgent need to understand how and why immune-related adverse events occur and how to best manage them. Dr. Reynolds is joined by Regina Santamarina, a family member of a patient with first-hand experience of these conditions. We are so grateful to her for giving her unique and personal perspective.