What is the impact of COVID-19 on communities of color and how have Mass General responses aimed at improving health equity? In this Massachusetts General Hospital Blum Center presentation from April 27, 2021, Aswita Tan-McGrory, MBA, MSPH, shares the many lessons of how the mistrust of the healthcare system among communities of color affected organizations’ ability to mitigate COVID-19, as well as how they have engaged these communities in the distribution of vaccines. In addition, she discusses the importance of race, ethnicity and language data collection in managing COVID-19 and addressing disparities, and successful strategies for collaborating with communities.