A team of researchers at Mass General Cancer Center has reviewed the state of research surrounding FLT3 inhibitors.
Amir Fathi, MD
Amir Fathi, MD
Program Director, Center for Leukemia
Departments, Centers, & Programs:
Mass General Cancer Center: Hematology Oncology
55 Fruit St.
Boston, MA 02114
- MD, Yale University School of Medicine
- Residency, Massachusetts General Hospital
- Fellowship, Johns Hopkins Hospital
American Board Certifications
- Hematology, American Board of Internal Medicine
- Internal Medicine, American Board of Internal Medicine
- Medical Oncology, American Board of Internal Medicine
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My research is focused on the development and clinical translation of novel therapies for acute leukemias. I currently lead multiple clinical trials at the Dana Farber Harvard Cancer Center for patients with advanced leukemia and hematologic malignancies. I have a specific interest in studying FLT3 inhibition, aurora kinase inhibition, and antibody-drug conjugates as novel therapies.
Fathi AT, DiNardo CD, Kline I, Kenvin L, Gupta I, Attar EC, Stein EM, De Botton S. Differentiation syndrome associated with enasidenib (AG-221), a selective inhibitor of mutant isocitrate dehydrogenase 2. JAMA Oncol, 2018;4(8):1106-10.
Fathi AT, Erba HP, Lancet JE, Stein EM, Ravandi F, Faderl S, Walter RB, Advani AS, DeAngelo DJ, Kovacsovics TJ, Jillella AP, Bixby D, Levy MY, O'Meara MM, Ho PA, Voellinger J, Stein AS. A phase 1 trial of vadastuximab talirine combined with hypomethylating agents in patients with CD33-positive AML. Blood, 2018;132(11):1125-33.
Brunner AM, Neuberg D, Wander SA, Sadrzadeh H, Ballen K, Amrein P, Attar E, Hobbs G, Chen YB, Perry A, Joseph C, Burke M, Ramos A, Galinsky I, Yen K, Yang H, Straley K, Agresta S, Adamia S, Borger, DR, Iafrate, A, Graubert TA, Stone R, Fathi AT. Isocitrate dehydrogenase 1 and 2 mutations, 2-hydroxyglutarate levels, and response to standard chemotherapy for patients with newly diagnosed acute myeloid leukemia. Cancer, 2019;125(4):541-9.
Stein EM, DiNardo CD, Fathi AT, Pollyea DA, Stone RM, Altman JK, Roboz GJ, Patel MR, Collins R, Flinn IW, Sekeres MA, Stein A, Kantarjian HM, Levine RL, Vyas P, MacBeth KJ, Tosolini A, Van Oostendorp J, Xu Q, Gupta I, Lila T, Risueno A, Yen KE, Wu B, Attar EC, Tallman MS, de Botton S. Molecular clearance and response patterns in patients treated with enasidenib, an oral inhibitor of mutant IDH2 proteins. Blood, 2019;133(7):676-87.