If you are interested in a consultation with the GI Cancer Genetics Program team, you can make an appointment at one of four locations:
Mass General Cancer Center main campus (Yawkey Building, Suite 10B, 55 Fruit St., Boston); call 617-724-1971
Mass General/North Shore Cancer Center (102 Endicott St., Danvers, MA); call 978-882-6370
Mass General Cancer Center at Emerson Hospital – Bethke (133 Old Road to Nine Acre Corner, Concord, MA); call 978-371-4805
Mass General Waltham (52 Second Ave., Suite 1110, Waltham, MA 02451); call 781-487-6100
Explore the Gastrointestinal Cancer Genetics Program
The Gastrointestinal Cancer Genetics Program helps to identify and provide comprehensive, coordinated medical care for families that have a hereditary colon or gastrointestinal cancer syndrome. Our program is led by Daniel C. Chung, MD, and includes specialists in both gastroenterology and genetics.
Patients with pathogenic variants in hereditary colon or gastrointestinal genes are managed comprehensively with our team of physicians and genetic counselors. We also provide risk assessment for patients interested in an evaluation for hereditary colon cancer or other gastrointestinal cancers. During the initial genetics consultation, family history is carefully reviewed. If your personal or family history suggests a possible genetic risk, we will discuss the option of genetic testing.
Should You Consider Genetic Counseling?
Our program is appropriate for any individual that has a pathogenic variant in a colon or gastrointestinal cancer predisposition gene. It may also be right for you if you have a personal or family history of one or more of the following:
Early-onset colorectal, uterine, stomach or other gastrointestinal cancers
Two or more primary colon or gastrointestinal cancers
Early-onset or multiple gastrointestinal polyps
Multiple family members with pancreatic cancer
Hereditary Gastrointestinal Cancer Diseases
The syndromes most commonly discussed with patients in our program include:
Lynch syndrome, also known as hereditary non-polyposis colorectal cancer (HNPCC) syndrome: People with Lynch syndrome are at an increased risk of colon, uterine, stomach, ovarian, small bowel and other types of cancers. The genes responsible for this syndrome are MLH1, MSH2, MSH6, PMS2 and EPCAM.
Familial adenomatous polyposis (FAP) syndrome: People with FAP have a greater risk of developing multiple colon and other gastrointestinal polyps as well as certain types of colon and other gastrointestinal cancers. The gene responsible for this syndrome is APC.
MUTYH-associated polyposis (MAP) syndrome: MAP syndrome results in an increased risk of multiple colon and other gastrointestinal polyps as well as colorectal cancer. The gene responsible for this syndrome is MUTYH.
Familial pancreatic cancer: Some families have an increased risk of developing pancreatic cancer. Depending on the other cancers in the family, genetic testing may be appropriate to help assess the risk to family members.
Colorectal cancer is the third most common cancer diagnosed in both men and women in the United States. A portion of these colon cancers are due to genetic predisposition genes. The Blum Center shares more in a recent presentation.
Contact the Mass General Cancer Center
Contact us to make an appointment or to learn more about our programs.