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Center for Engineering in Medicine
The Organ Reengineering Group at the Center for Engineering in Medicine is working to develop new applications to increase the viability of transplantable organs.
•Korkut Uygun, PhD•Basak Uygun, PhD•Marianna Bei, PhD•Martin Yarmush, MD, PhD•Mehmet Toner, PhD•Ron Tompkins, MD, ScD•Shannon N. Tessier, PhD
Organ transplantation remains the only solution to many diseases, including organ failure. Approximately 120,000 patients are currently on the organ waiting list in the U.S. alone. Most will perish while waiting for a donor organ.
Despite the apparent shortage, the number of donors available for organ recovery is in the hundreds of thousands. The problem is that most of these organs are suboptimal, and without treatment must be precluded from transplantation.
Our group aims to develop novel approaches to render these organs transplantable and ultimately eliminate the donor organ shortage. Our research focuses on the development of an organ revitalization platform, the basis of which is extracorporeal machine perfusion enabling multiple dynamic preservation modalities.
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