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Directory of Faculty by Research Thrust

Postdocs

Meet the postdoctoral research fellows from the Center for Engineering in Medicine & Surgery at Massachusetts General Hospital.

Ezgi Antmen headshotEzgi Antmen, PhD, MSc

Education:
Ph.D., Biotechnology, METU, 2017
M.Sc., Biology, METU, 2013
B.Sc., Molecular Biology and Genetics, METU, 2011
 
 
Research: 
My current research focuses mainly on the microfluidic T-cell isolation and expansion from leukapheresis products for cancer immunotherapy manufacturing. I also work on 3D culturing of tumor cells and targeted nanoparticles for drug delivery to tumor cells.

Fan headshot

Letao Fan

Education:
PhD, Experimental Therapeutics and Pharmacology, University of Mississippi Medical Center, Jackson, MS, USA, 2021
MS, Biomedical Engineering, National Taiwan University, Taipei, Taiwan, 2017
BS
Electrical/Electronic Engineering, Tunghai University, Taichung, Taiwan, 2015

Research:
My current projects involve using iPSC-derived endothelial cells and hepatocytes to develop transplantable skin and liver grafts from decellularized tissues/organs, study of altered drug ADME in non-alcoholic fatty liver disease and early diagnostic markers of drug-induced liver disease in exosomes, and the development of automated ex-vivo machine-perfusion system.


A. Aslihan Gokaltun, PhD

A. Aslihan Gokaltun, PhD

Education:
PhD, Chemical Engineering, Hacettepe University, 2014
MS, Chemical Engineering, Hacettepe University, 2009
BS, Chemical Engineering, Hacettepe University, 2007

Contact:
Contact by email

Research:
I have a strong background that crosses polymer design, synthesis and characterization, materials science and surface engineering. In my past studies, I synthesized new, promising reactive polymeric microparticles and monoliths for the separation of various compounds in chromatographic applications with suitable chemistries, porosity properties and high specific surface areas.

I’m also an expert in various chemical synthesis/surface functionalization methods for the prevention of the fouling or the non-specific adsorption of proteins and other biomacromolecules on surfaces. Non-specific protein adsorption is a significant challenge in biomaterials including biomicrofluidic devices.

At CEMS, I am using my background in chemical engineering and I’m designing and synthesizing novel polymeric materials to control bulk and surface properties of PDMS using scalable approaches to significant challenges in the manufacture of microfluidic devices with no added steps.


Shijie He, PhD

Shijie He, PhD

Education:
PhD, Biomechanics, Beijing Institute of Technology, 2016
BS, Engineering of Mechanics, Dalian University of Technology, 2010

Contact:
Contact by email

Research:
I am mainly interested in cell mechanics, i.e. the roles of physical/mechanical factors including forces, stiffness, geometries in cell migration, proliferation and differentiation. Currently I am studying the effects of extracellular matrix on intestinal organoids which are derived from primary intestinal stem cell.


Alex Hopke, PhD

Alex Hopke, PhD

Education:
PhD, Microbiology, The University of Maine, 2016
BS, The University of Maine, 2010

Contact:
Phone: 978-758-0692
Contact by email

Research:
Using a micro-spotting machine, I am examining the behaviors of immune cells during interactions with microbes, particularly the “neutrophil swarming” behavior. The role of neutrophil swarming during injury and infection in humans is poorly understood. Through our investigations we hope to both gain insight into the importance of swarming in humans and to apply this knowledge to develop ways to assist patients who may have swarming defects.


Ziya Isiksacan, PhD

Ziya Isiksacan, PhD

Education:
PhD, Materials Science & Nanotechnology, Bilkent University, 2020
MS, Bioelectronics & Biosensors, Edinburgh University, 2014
BS, Electrical & Electronics Engineering, Koc University, 2012

Contact:
Contact by email

Research:
I study red blood cell dynamics to measure blood material properties and key hemorheological parameters. To this end, I develop portable diagnostic platforms and fabricate microfluidic chips using novel fabrication techniques. I am interested in optimizing red blood cell storage conditions through deep supercooling to enable safer blood transfusion. I focus on biochemical and biophysical aspects of blood coagulation and thromboembolism.


Rohil Jain, PhD

Rohil Jain, PhD

Education:
PhD, School of Mechanical Engineering, Purdue University, 2021
Bachelor of Technology, Mechanical Engineering, Indian Institute of Technology Delhi, 2013

Contact:
Contact by email

Research:
My research at the CEMS primarily focuses on developing liquid biopsy assay for analyzing circulating biomarkers of injury and rejection in solid organ transplants. I also develop non-invasive technologies for analyzing the quality of liver grafts for liver transplants. These technologies are used for analyzing health of the organ before the transplant when it may be machine perfused, or for analyzing health of the graft after transplantation in a patient.


Justyna Jaskiewicz

Justyna Jaskiewicz, PhD, MSc, DVM

Education:
PhD, Infectious Diseases, Tufts University, 2020
MSc, Control of Infectious Diseases, Royal Veterinary College, 2012
DVM, Veterinary Medicine, Warsaw University of Life Sciences, 2008

Contact:
Contact by email

Research:
As a biomedical researcher with background in veterinary medicine I am interested in studying zoonotic and One Health pathogens of global health importance. My investigations at the CEMS focus on methods of preservation of apicomplexan parasites of Cryptosporidium and Plasmodium species.


Purva Joshi headshot

Purva Joshi, PhD

Education:
Ph.D., Mechanical Engineering, Carnegie Mellon University, 2021
M.S. Mechanical Engineering, Carnegie Mellon University, 2017
B.E. Mechanical Engineering, Pune University, 2015
 
 
Research: 
I am a mechanical engineer with a background in thermal sciences, solid mechanics, computation and engineering modeling. At CEMS, I am working on developing and optimizing preservation strategies for Anopheles mosquito and Drosophila embryos.

Gunes Kibar, PhD, MS

Gunes Kibar, PhD, MSc

Education:
PhD, Bioengineering, Hacettepe University, 2016
MSc, MBA,Hacettepe University, 2015
MSc, Bioengineering,Hacettepe University, 2009
BSc, Chemical Engineering,Hacettepe University, 2007

Contact:
Contact by email

Research:
Targeted drug delivery systems are vital for the treatment of inoperable with only local disease and unresectable types of liver cancer, which are the third leading cause of cancer-related death in the worldwide. The project offers a new drug loading strategy to improve drug delivery efficacy, increase the fusion with target cell, reduce side effects, lower treatment cost by using microfluidic systems for the production of micro/nanostructured lipid carriers in monodisperse, negative charged and para-magnetic form. The performance of drug carrier/cell interaction will be tested on hepatocellular carcinoma cell lines.


Jae Jung Kim, PhD

Jae Jung Kim, PhD

Education:
PhD, Chemical Engineering, Massachusetts Institute of Technology, 2017
BS, Chemical & Biological Engineering, Seoul National University 2012

Contact:
Phone: 857-200-0458
Email: Contact by email

Research:
My research focuses on the development of a ‘skin-on-a-chip’ device to study the neutrophil behavior in the skin. Using the controllability of microfluidic devices, this study will provide the fundamental knowledge of how neutrophil function in skin disease, such as cellulitis. Eventually, I will apply my knowledge towards the development of rapid diagnostic tool for skin disease.


Joao Paulo Oliveira da Costa, PhD

Joao Paulo Oliveira da Costa, PhD

Education:
PhD, Pathology, University of Sao Paulo, Brazil, 2014
MS, University of Sao Paulo, Brazil, 2010
DDS, Alfenas Federal University, Brazil, 2006

Contact:
Phone: 617-643-7213
Contact by email
Website

Research:
My research is focused in identifying molecular markers of progression in adult and pediatric solid tumors. We use circulating tumor cells and exosomes as models for blood-based biopsies to identify such markers, and better understand how tumors spread and metastasize. Using microfluidic technologies, we isolate tumor-specific exosomes and circulating tumor cells for downstream analysis such as single cell RNA sequencing, digital droplet PCR, label-free mass spectrometry and next generation sequencing.

Furthermore, I still try to integrate Anatomic Pathology into state-of-art technologies, such as microfluidic isolation of tumor-derived cargo, and to single-cell analysis of tumor content. Maintaining tissue architecture as part of analysis is a powerful way of understanding more than cell signaling pathways, but also to understand how those different tumor cells interact in space. To achieve this goal I apply multispectral imaging and multiplexed immunohistochemistry to validate single cell RNA-Seq results, providing important clues on how tumor architecture helps shape the multiclonal nature of tumor cells, and how they interact with the microenvironment.


Daniel C Rabe, PhD

Daniel C Rabe, PhD

Education:
PhD, Cancer Biology, University of Chicago, 2017
MS, Translational Research, University of Chicago, 2014
BA (with honors), Chemistry, University of Chicago, 2007
BS (with honors), Biochemistry, University of Chicago, 2007

Contact:
Contact by email

Profile:
Researchgate

Research:
My current project is utilizing single-cell in droplet (inDrop) RNAseq to understand how tumor extracellular vesicle (EV) secretion is altering the tumor microenvironment in glioblastoma. Additionally, we are examining how tumor and immune EVs isolated using microfluidics developed in the Stott laboratory can be utilized as biomarkers for response to immunotherapy.


Derin Sevenler, PhD

Derin Sevenler, PhD

Education:
PhD, Biomedical Engineering, Boston University, 2017
BS, Mechanical & Aerospace Engineering, Cornell University, 2011

Contact:
Contact by email

Research:
I'm a biomedical engineer with a background in optics, automation and biomolecular assay development. I'm broadly interested in technology development for both biomedical research and applications in healthcare. Right now I'm working on several projects related to infectious disease and biopreservation. For example, one of my current projects involves researching new approaches to cryopreserve living cells, model organisms and pathogens so they can be studied in the lab or made available for therapeutic use.


Zhan headshot

Li Zhan

Education:
PhD, Mechanical Engineering, University of Minnesota, 2020
BS, Mechanical Engineering, Xi’an Jiaotong University, 2014

Contact:
lzhan@mgh.harvard.edu

Research:
My research background lies in cryopreservation, point-of-care diagnostics, and laser-nanoparticle interaction. My project at the CEMS primarily focuses on the enrichment of skin stem cells using microfluidic techniques.


Technical Staff

Suhaas Garre

Suhaas Garre

Research Engineer



Education:

BS Bioengineering, UC Berkeley 2018

Contact:
Contact by email

As part of the Stott Lab, I am mainly involved with computational spatial analysis of Multi-Spectral Imaging (MSI) data, as well as implementation of deconvolutional methods for RNA sequencing. I am also researching the application of computer vision to the problem of cell segmentation.


Anika Marand

Anika Marand

Title:
Research Engineer

Education:
BS in Biological Sciences and BS in Biochemistry, Virginia Tech, 2016

Contact:
Contact by email

Research: I am involved with a clinical study with ER patients that uses microfluidics as a diagnostic tool for early detection of sepsis using a drop of whole blood. I look at the interactions between antibiotic treated neutrophils and S. aureus, which have led to clinical studies taking skin biopsies and blood samples from patients with staph infections. This will hopefully lead to future developments of diagnostic platforms for better diagnosing diseases like cellulitis.

Lastly, I’m working at the forefront of the Dicty World Race where laboratories from around the world send in genetically engineered dictyostelium discoideum cells, other amoebas and mammalian leukocytes to race against neutrophils, the ultimate chemotaxic cell.


Jessica Wallace

Jessica Wallace

Research Engineer

Education:
BS, Biomedical Engineering, University of Connecticut, 2017

Contact:
Contact by email

I am currently working on isolating circulating tumor cells (CTCs) and circulating tumor cell clusters from whole blood samples. These cells, and more prominently cell clusters, can give important information on the diagnosed cancer. Using various microfluidic technologies, we are working to develop an optimum chip to isolate these cells, for further research, without damaging them.


Akansha Deshpande

Akansha Deshpande

Research Engineeer

Education:
BS, Biomedical Engineering, Worcester Polytechnic Institute, 2021

Contact:
Contact by email

I am currently working on isolating circulating tumor cells (CTCs) and circulating tumor cell clusters from large volume samples using ultrahigh throughput microfluidic cell sorting technologies. These cells and cell clusters can give important information for cancer diagnostics, disease monitoring and personalized treatment.


Hannah Stowe

Hannah Stowe

Research Technician

Education:
BS, Biology, Tufts, 2019; MS, Biomedical Sciences, Tufts 2021

Contact:
Contact by email

I am working on isolating brain endothelial cells using microfluidic technology for developing blood-based diagnostics for brain trauma. Also, I am working on analysis of bone marrow stromal cells using mass cytometry in order to categorize different cell types found in the bone marrow microenvironment.


Rein headshot

Carlie Rein

Research Engineer


Education:
B.S.E., Biomedical Engineering, Arizona State University, 2021

Contact:
Contact by email

Research:
I am currently working on isolating circulating tumor cells with microfluidic cell sorting technology to provide insight on cancer, early diagnostics and individual treatment. I am also applying microfluidic technology for regenerative medicine.


Other Personnel

Personnel at the Center for Engineering in Medicine & Surgery, part of the Department of Surgery at Massachusetts General Hospital.

Jon F. Edd, PhD

Jon F. Edd, PhD

Education
PhD, Mechanical Engineering, University of California, Berkeley, CA, 2006
BS, Mechanical Engineering, University of Texas, Austin, TX, 2001

Contact:
Contact by email

Research:
As a member of the innovation team at the Center for Engineering in Medicine & Surgery, my primary focus is to develop rare cell isolation technologies. This includes antigen-agnostic isolation of circulating tumor cells (CTCs), CTC clusters, and bacteria, from whole blood.


Ravi Kupur, PhD

Ravi Kupur, PhD

Education
PhD, Bioengineering, Clemson University, Clemson, SC, 1995
MS, Bioengineering, Clemson University, Clemson, SC, 1991
BE, Electrical and Electronics Engineering, India, 1989

Contact:
Phone: 781-363-3530
Contact by email
Website: www.micro-medicine.com

Research:
Innovation to bring nascent technologies through development, clinical translation and commercial launch. Specializing in rare cell isolation for detection, diagnosis and therapy. Current initiatives include the transition to commercial setting of the circulating tumor cell isolation platform & commercial development of automated microfluidic platform for autologous cellular therapy and diagnosis.


Jonah Poster

Jonah Poster

Education
BA, Honors Economics and Sociology, New York University, 2013
Post-Baccalaureate Pre-Medical Program, Harvard Extension School, 2017

Contact:
Contact by email
Website: https://orcid.org/0000-0002-1868-5963

Director of Sponsored Clinical Research
I am responsible for the management of sponsored clinical research studies for pediatric acute burn injuries. This primarily involves investigational device and investigational drug studies on burn imaging, phototherapy to reduce microbial burden, regenerative epithelial suspension and debridement enzyme agents. Additionally, I write papers analyzing critical care methods and surgical techniques of pediatric burn wounds.