A new study demonstrated for the first time an effective method of increasing bone mineral density in girls with anorexia nervosa.
Madhusmita Misra, MD, MPH
Madhusmita Misra, MD, MPH
Division Chief, Pediatric Endocrinology
Fritz Bradley Talbot and Nathan Bill Talbot Professor of Pediatrics, Harvard Medical School
Departments, Centers, & Programs:
Mass General for Children: Pediatric Endocrine Program and Diabetes Center
55 Fruit St.
Boston, MA 02114
- MPH, Harvard T. H Chan School of Public Health
- MBBS, SCB Medical College
- Residency, Maimonides Medical Center
- Fellowship, Massachusetts General Hospital*****
American Board Certifications
- Pediatric Endocrinology, American Board of Pediatrics
Accepted Insurance Plans
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Research within the Pediatric Endocrine-Neuroendocrine-Sports Endocrine Lab aims to further knowledge about endocrine, metabolic, bone, neurocognitive and neuropsychiatric outcomes in girls with low-weight eating disorders, athletes, teenagers and young adults undergoing bariatric surgery or receiving obesity pharmacotherapy, children with diabetes and those with autism spectrum disorders.
Ongoing studies include the following:
- The Role of Estrogen in the Neurobiology of Eating Disorders: A Study of Cognitive Flexibility and Reward in Eating Disorders
- Bone Metabolism in Adolescents Undergoing Bariatric Surgery
- Determinants of bone microarchitectural compromise in youth with type 1 diabetes
- Oxytocin as a neuroendocrine therapy for obesity in youth
Selected Original Articles (from over 190)
1. Misra M, Katzman DK, Miller KK, Mendes N, Snelgrove D, Russell M, Goldstein MA, Ebrahimi S, Clauss L, Weigel T, Mickley D, Schoenfeld D, Herzog DB, Klibanski A. Physiologic Estrogen Replacement Increases Bone Density in Adolescent Girls with Anorexia Nervosa. J Bone Miner Res 2011;26:2430-8
2. Ackerman KE, Singhal V, Baskaran C, Slattery M, Campoverde Reyes K, Toth A, Eddy KT, Bouxsein ML, Lee H, Klibanski A, Misra M. Oestrogen Replacement Improves Bone Mineral Density in Oligo-amenorrheic Athletes: A Randomized Clinical Trial. Br J Sports Med 2019;53(4):229-236.
3. Singhal V, Ackerman KE, Bose A, Torre Flores LP, Lee H, Misra M. Impact of Route of Estrogen Administration on Bone Turnover Markers in Oligoamenorrheic Athletes and Its Mediators. J Clin Endocrinol Metab 2019 May 1;104(5):1449-1458.
4. Bredella MA, Singhal V, Karzar NH, Animashaun A, Bose A, Stanford FC, Carmine B, Misra M. Effects of sleeve gastrectomy on bone marrow adipose tissue in adolescents with severe obesity. J Clin Endocrinol Metab 2020 Nov 1;105(11):e3961-70.
Selected Reviews (from ~100 reviews and position statements)
1. Misra M, Pacaud D, Petryk A, Collett-Solberg P, Kappy M. Vitamin D Deficiency in Children and its Management: Review of Current Knowledge and Recommendations. Pediatrics 2008; 122: 398-417.
2. Misra M. Effects of Hypogonadism on Bone Metabolism in Adolescent and Young Adult Women. Nat Rev Endocrinol 2012;8(7):395-404
3. Misra M, Klibanski A. Endocrine Consequences of Anorexia Nervosa. Lancet Diab Endocrinol 2014;2(7):581-92.
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Massachusetts General Hospital researchers have conducted the first study on individuals with anorexia that relates hunger and satiety to hormonal changes after a meal.