Over the course of 2019, Molly Janielis, 20, learned a lesson that many people learn much later in life – that change is possible for anyone if you put your mind to it.
Sonali Malhotra, MBBS
Sonali Malhotra, MBBS
Instructor at Harvard Medical School
Departments, Centers, & Programs:
Pediatric Endocrine Associates
55 Fruit Street
Boston, MA 02114-2696
- MBBS, Indira Gandhi Medical College
- Residency, Lincoln Medical & Mental Health Center
- Fellowship, Maimonides Medical Center
- Fellowship, Massachusetts General Hospital
American Board Certifications
- Pediatrics, American Board of Pediatrics
- Pediatric Endocrinology, American Board of Pediatrics
Accepted Insurance Plans
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Dr. Malhotra has worked on investigating the role of important receptors named “Toll like receptor 2 and 4” (TLR-2 and TLR-4) in the pathogenesis of obesity, insulin resistance, and other obesity related complications in children and adolescents. The results from this study will provide crucial information about the underlying mechanism of how the inflammatory response is triggered in childhood obesity, and how it can lead to complications of childhood obesity.
She is currently collaborating with the Rhythm pharmaceuticals in a study for Genetic Testing and Phenotypic Characterization of Severely Obese Pediatric and Adult Volunteers, the objective of which is to identify individuals with severe, early onset morbid obesity (EOMO), who are suspected to have mutations in the POMC, PCSK1 or LepR gene, leading to clinical presentation of Melanocortin 4 (MC4R) pathway deficiency obesity.
Other areas of her research include elucidating anti-neoplastic treatment effectiveness in cancer patients with concomitant obesity.
Dr. Malhotra published the pioneer study examining the effects of current marijuana use on thyroid function and autoimmunity in human subjects. The study reported that current marijuana use, in short term, is associated with lower levels of thyroid stimulating hormone (TSH), which is the key regulatory hormone controlling the thyroid gland. In lines with these pivotal findings several studies are in process of further investigating the prospective effects of marijuana use on the various other hormonal axes in humans.
Malhotra S, Heptulla RA, Homel P, Motaghedi R: Effect of Marijuana Use on Thyroid Function and Autoimmunity. Thyroid: official journal of the American Thyroid Association 2017, 27(2):167-173.
Ghanny BA, Malhotra S, Kumta S, Kazachkova I, Homel P, Jacobson-Dickman E, Motaghedi R. Should children with isolated premature adrenarche be routinely evaluated for non-classical congenital adrenal hyperplasia? J Pediatr Endocrinol Metab. 2015 Dec 7