Ali Topaloglu, MD
Ali Topaloglu, MD
Departments, Centers, & Programs:
Mass General for Children: Pediatric Endocrine Program and Diabetes Center
55 Fruit St.
Boston, MA 02114
Brigham and Women's/Mass General Health Care Center at Foxborough
20 & 22 Patriot Place
Foxboro, MA 02035
Mass General for Children at Blue Hills Medical Center
340 Wood Rd.
Braintree, MA 02184
- MD, Cukurova University School of Medicine
- Residency, Istanbul Zeynep Kamil Children's Hospital
- Fellowship, Loyola University Medical Center
- Fellowship, Mount Sinai School of Medicine
American Board Certifications
- Pediatrics, American Board of Pediatrics
Accepted Insurance Plans
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Throughout human development, the activities of the hypothalamo-pituitary-gonadal (HPG) axis from late embryo to young adulthood are crucial. Dr. Topaloglu has dedicated his efforts to gaining complete insight into the central regulation of the HPG axis, particularly what drives pubertal onset. Collaborating with his colleagues for the past 15 years, Dr. Topaloglu has identified and reported several genes associated with pubertal failure. The most notable of these genes are TAC3, TACR3, and KISS1, which are instrumental in defining our current understanding of the GnRH pulse generator as the KNDy neurons in the hypothalamic arcuate nucleus. The KNDy cells consist of kisspeptin, neurokinin B, and dynorphin, each with a distinct role in generating GnRH pulses. The KNDy cells are reactivated at the beginning of the second decade of human life, which signals the start of puberty, a major life event that marks the end of childhood and the beginning of adolescence. This new stage is characterized by developing secondary sex characteristics, maturing reproductive capacity, and psychosocial identity. However, the stimulus that reactivates the GnRH pulse generator after a prolonged quiescence during childhood remains an enigma, and identifying such a stimulus is Dr. Topaloglu's current research challenge.