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To make an appointment in the Tourette Syndrome/Tic Disorders Clinic, call Matthew Kaufman at 617-726-5532.
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MassGeneral Hospital for Children
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Dr. Scharf is a behavioral neurologist and tic disorder specialist as well as a clinical researcher in molecular genetics. He received his B.S. from Yale University, his M.D. from the Harvard-MIT Division of Health Sciences and Technology (HST) at Harvard Medical School, and his Ph.D. in Neurobiology from Harvard University. Following neurology residency at Massachusetts General and Brigham and Women's Hospitals, Dr. Scharf completed subspecialty training in behavioral neurology/neuropsychiatry at BWH and a research fellowship in the MGH Psychiatric Neurodevelopmental Genetics Unit and the Broad Institute of MIT and Harvard.
Dr. Scharf specializes in disorders that lie at the interface between neurology and psychiatry, particularly Tourette Syndrome (TS) and related conditions. He co-directs the TS Center of Excellence with Dr. Sabine Wilhelm in MGH Psychiatry to provide inter-disciplinary care for patients with tic disorders. He also supervises fellows in adult and pediatric movement disorders and behavioral neurology/neuropsychiatry to train them in diagnosis and management of these conditions.
Dr. Scharf's research focuses on identifying genetic and non-genetic risk factors for TS and related disorders (e.g., OCD and ADHD). Using statistical and molecular genetic techniques, his lab aims to integrate genetic discoveries with bio-informatic and experimental data to determine the molecular, cellular and circuit-level dysfunction underlying TS, OCD and ADHD to enable the development of targeted therapies.
Dr. Scharf co-chairs the TAA International Consortium for Genetics, a team of clinicians and geneticists dedicated to identifying TS susceptibility genes, and the Psychiatric Genetics Consortium TS/OCD Working Group. He has received grants from the Tourette Association of America, the American Brain Foundation, NINDS, NIMH, NIA and NHGRI.
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View my most recent publications at PubMed
An international research team led by investigators at Massachusetts General Hospital and the University of California at Los Angeles has identified rare mutations in two genes that markedly increase the risk for Tourette syndrome, a neurodevelopmental disorder characterized by chronic involuntary motor and vocal tics.
A new study of Tourette syndrome (TS) led by researchers from the University of California at San Francisco and MGH has found that nearly 86 percent of patients who seek treatment for TS will be diagnosed with a second psychiatric disorder during their lifetimes, and that nearly 58 percent will receive two or more such diagnoses.
An international research consortium led by investigators at MGH and the University of Chicago has answered several questions about the genetic background of obsessive-compulsive disorder and Tourette syndrome, providing the first direct confirmation that both are highly heritable and also revealing major differences between the underlying genetic makeup of the disorders.
Two papers that will appear in the journal Molecular Psychiatry, both receiving advance online release, may help identify gene variants that contribute to the risks of developing obsessive-compulsive disorder or Tourette syndrome.
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