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Dr. Carroll holds an MPH in International Health and an MD with a focus in International Health. He is an attending physician in the pediatric ICU at MGHfC and he maintains research and development efforts in pediatric care delivery in low-resource settings, including Uganda, Liberia, India, and Lebanon.
Ryan Carroll is a faculty member with the division of Pediatric Critical Care at MGH. Earlier in his career he focused on the pathophysiology of cerebral malaria and the role of nitric oxide, investigating disease in a mouse model and in children in Malawi and Uganda. He and his team completed a randomized controlled trial to determine the safety and efficacy of inhaled nitric oxide in Ugandan pediatric patients with cerebral malaria, a joint research venture between MGH and Medicins Sans Frontieres (MSF)/Doctors Without Borders. Recognizing the power of building critical care and research capacity in low- resource settings (LRS), Dr. Carroll transitioned to be the Program Director in Uganda with the Global Health Collaborative, a research and development venture between MGH Global Health and the second largest teaching hospital and medical school in Uganda, the Mbarara University of Science and Technology. During his 3.5-year tenure in Uganda, Dr. Carroll oversaw over 20 research projects, over 100 employees, the majority of whom were Ugandan, 10 departmental partnerships including a new pediatric oncology development project, over 200 international visitors per year, and a robust safety and security and wellness program. Dr. Carroll continued his work in the PICU during these years, and continues now, pursuing pediatric-specific projects, including: 1. continuous positive airway pressure (CPAP) development for LRS, including India and Uganda; 2. High-flow nasal cannula and pressure delivery; 3. CPAP implementation in Liberia with MSF; 4. The development of a PICU with MSF in the Bekaa Valley, Lebanon, caring for the 200,000+ Syrian refugee children in the region.
View my most recent publications at PubMed
1. Carroll RW, Wainwright MS, Kim K-Y, Kidambi T, Gómez ND, Taylor T, Haldar K. A rapid murine coma and behavior scale for quantitative assessment of murine cerebral malaria. PLoS ONE. 2010 Oct; 5(10): pii: e13124. doi: 10.1371/journal.pone.0013124.
2. Mwanga-Amumpaire J*, Carroll RW*, Baudin E, Kemigisha E, Nampijja D, Mworozi K, Santorino D, Nyehangane D. Nathan DI, De Beaudrap P, Etard J-F, Feelisch M, Fernandez BO, Berssenbrugge A, Bangsberg D, Bloch KD, Boum Y 2nd, Zapol WM. Inhaled nitric oxide as an adjunctive treatment for cerebral malaria in children: a phase II randomized open-label clinical trial. Open Forum Infectious Diseases. 2015 Jul 24; 2(3):ofv111. doi: 10.1093/ofid/ofv111. *Authors contributed equally
3. Bortcosh W, Siedner M, Carroll RW. Utility of the urine reagent strip leukocyte esterase assay for the diagnosis of meningitis in resource-limited settings: Meta-analysis. Trop Med Int Health. 2017 Sep;22(9): 1072 – 1080. doi: 10.1111/tmi.12913
4. Bennett DJ, Carroll RW, Kacmarek B. Evaluation of a low-cost bubble CPAP system designed for resource-limited settings. Resp Care. 2018 Jan 30. doi: 10.4187/respcare.05762.
Drs. Warren Zapol and Ryan Carroll of the Anesthesiology Center for Critical Care Research and are currently leading a phase II clinical trial in the safety and efficacy of inhaled nitric oxide as an adjunctive treatment for pediatric patients with cerebral malaria in Uganda (ClinicalTrial.gov: NCT01388842).
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