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Over the years, our researchers have made significant advancements in genetics and genomics, imaging technologies, less invasive surgical techniques and an abundance of treatment options that are changing the way pediatric care is delivered.
Pediatric Translational Research Center
My laboratory is interested in the development of the enteric nervous system (ENS), a complex neuronal network whose principal function is to maintain normal intestinal motility.
We provide innovative opportunities for people with Down syndrome to participate in research.
The main focus of my laboratory centers on the bacterial pathogen Shigella flexneri, which causes millions of infections in children each year.
The First 1,000 Days aims to improve the health of families from pregnancy through age 2 by engaging providers from both clinical and community health services. It is being piloted at the MGH Chelsea and Revere HealthCare Centers and DotHouse Health.
The Division of General Academic Pediatrics is an internationally-known academic research division dedicated to improving the health of children and adolescents.
The Division of Global Health (DGH) at MassGeneral Hospital for Children includes energetic faculty members and senior research fellows. The Division's primary mission is to build and foster international partnerships for interdisciplinary research, education and service to reduce health disparities and achieve optimal health for children and adolescents in resource-limited settings of the developing world. Our multidisciplinary team of faculty has significant experience working in the global arena, and in mentoring and teaching future leaders in global health.
The Gobel Laboratory studies polarity, epithelial morphogenesis and growth regulation in Caenorhabditis elegans.
The Jason Harris, MD, MPH and Regina LaRocque, MD, MPH Laboratory is focused on host-pathogen interactions and the innate and adaptive immune response to Vibrio cholerae, cholera vaccines, and in the area of susceptibility to cholera.
Experiments carried out by our group are directed at understanding the mechanisms that regulate intestinal innate immune responses to pathogenic and commensal bacteria.
The Jain Lab is working to understand how the immune system develops and operates in newborns in order to develop new approaches to improving infant health.
The Perrin group studies chronic health conditions in children and adolescents, with particular focus on autism spectrum disorders (ASD). Recent work has examined care improvement for children with ASD and racial and ethnic disparities in autism diagnosis and care. The team also provides evidence to support decision-making regarding newborn genetic screening and has examined recent policy and changes regarding public programs supporting children with disabilities (the Supplemental Security Income [SSI] program).
The Roberts Laboratory is devoted to investigating novel mechanisms and developing new therapies for important pediatric lung diseases.
The Mou Laboratory in the Mucosal Immunology and Biology Research Center at Massachusetts General Hospital applies stem cell technologies to investigate personalized medicine approaches for lung and airway diseases including cystic fibrosis, asthma, bronchopulmonary dysplasia (BPD) and chronic obstructive pulmonary disorder (COPD).
Our focus is to better understand inflammatory processes impacting mucosal surfaces, particularly in the lung and digestive tract.
The Pediatric Airway, Swallowing and Voice Center, a collaboration of MassGeneral Hospital for Children and the Massachusetts Eye and Ear Infirmary, specializes in conducting research to treat children with voice disorders and airway management symptoms that affect the ability to eat, breathe or speak.
Research within the Pediatric Endocrine-Neuroendocrine-Sports Endocrine Lab aims to further medical knowledge about endocrine, bone, neurocognitive and neuropsychiatric outcomes in athletes, girls with low-weight eating disorders, teenagers and young adults undergoing bariatric surgery, and children with autism spectrum disorders. In particular, we focus on studies whose results allow us to adapt and improve medical care for female athletes and young girls and women with eating disorders.
The goal of our laboratory research is to find ways to generate regulated insulin secretion in cells or tissues for pancreatic b-cell replacement therapy in diabetes.
The mission of the Pediatric Radiation Oncology Research program is to continuously improve cancer treatment and outcomes in our pediatric patients through innovative and collaborative research that we translate into clinical care.
The Pediatric Surgical Research Laboratories focus on areas of Developmental Biology which hold promise for clinical application for birth defects and cancer prevention and treatment.
The Shi Lab is researching the effects of infections and immune disorders on the intestine and the role of gestational factors in the development of child allergies.
The Oottamasathien Laboratory at Massachusetts General Hospital is focused on understanding the inflammatory cascade for better care and treatment of those suffering from IC/PBS.
We conduct leading scientific research to better understand concussions in young people and to develop better approaches to assessment, treatment, and rehabilitation.
The Teratology Program focuses on the study of the causes of congenital malformations.
The research efforts of the Walker Lab include defining the passive and active protective properties of human breast milk with regard to the protection from disease during the newborn period.
The Warren Laboratory researches the pathogenesis and treatment of serious bacterial infections, sepsis, and induced secondary inflammation from any cause.
The MIBRC conduct basic research in mucosal immunology topics ranging from Salmonella food poisoning to intestinal inflammatory diseases such as celiac disease.
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