Departments, Centers, & Programs:
Neurology & Stroke Services
15 Parkman Street
Boston, MA 02114-3117
- MMSc, Harvard University
- MD, University of Giessen
- PhD, University of Regensburg
- Residency, Brigham and Women's Hospital
- Residency, University of Regensburg
- Fellowship, Massachusetts General Hospital
American Board Certifications
- Neurology, American Board of Psychiatry and Neurology
Accepted Insurance Plans
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My main research focus has been the study of neural precursor cell biology in the context of neurological disease. Our work has shown that abnormal progenitor and stem cell function is underlying diverse neurological diseases, including leukodystrophies, viral infections, brain cancer and neurotoxicity following cancer therapy. Abnormal neural progenitor cell function has also tremendous implications for our understanding of conditions with chronic and progressive neurological impairment, such as neurodegenerative diseases.
An important area of our current investigation is the study of the cell-biological basis of neurotoxicity following cancer treatment. We were able to demonstrate that lineage-committed progenitor cells belong to the most sensitive cell populations to chemotherapy. These studies have provided the foundation for the development of neuroprotective and cellular repair strategies that are currently being assessed for their application in clinical trials.
Another focus of our current research studies is the characterization of the neurovascular niche. Neurogenesis and gliogenesis, the generation of new neurons and glia cells, occur in well-defined 'niches' composed of neural stem cells, progenitors, astrocytes, and vascular components. The neurovascular niche is therefore characterized by a intersection between neuroectodermal and mesenchymal cell system. The neurovascular niche is critically important in the formation of brain tumors, in treatment resistance and in tumor progression. Our studies aim to provide novel insights into the unique interplay between mesenchymal and neuroectodermal tissues and to identify novel therapeutic targets for tumor therapy and novel strategies to enhance endogenous brain repair.
- Frigault MJ et al. Tisagenlecleucel CAR-T cell therapy in secondary CNS lymphoma. Blood, 2019
- Karschnia P et al. Clinical presentation, management, and potential biomarkers of neurotoxicity after CAR-T cells. Blood, 2019
- Winter SF et al. Treatment-induced brain tissue necrosis: a clinical challenge. Neuro-Oncology, 2019
- Karschnia P et al. Pharmacologic management of cognitive impairment induced by cancer therapy. Lancet Oncology, 2019
- Dietrich J et al., Bone marrow drives central nervous system regeneration after radiation injury. J Clin Invest, 2018
- Herlopian A et al., EEG findings in CAR-T cell therapy related encephalopathy. Neurology, 2018
- Prust M et al. Standard chemoradiation in combination with VEGF targeted therapy for glioblastoma results in progressive gray and white matter volume loss. Neuro-Oncology, 2018
- Dietrich J et al. Neuroimaging in brain tumor patients: Pseudoprogression, pseudoresponse and delayed effects of radiation therapy. Seminars in Neurology, 2017
- Vaios EJ et al. Bone marrow response as a potential biomarker of outcomes in glioblastoma. J Neurosurg, 2016
- Prust MJ et al. Standard Chemotherapy for glioblastoma results in progressive brain volume loss. Neurology, 2015
- Tanaka S et al. Diagnostic and therapeutic avenues for glioblastoma: no longer a dead end? Nature Rev Clin Oncology, 2013
- Dietrich J et al. Mechanisms of Disease: Neural Stem Cells and Gliomas. Nature Clin Pract Oncol, 2008
- Dietrich J et al. EIF2B5 mutations compromise generation of GFAP+ astrocytes from neural precursors in Vanishing White Matter leukodystrophy. Nature Medicine, 2005