About Pradeep Natarajan, MD, MMSc

Dr. Natarajan is the Director of Preventive Cardiology and the Paul and Phyllis Fireman Endowed Chair in Vascular Medicine at Massachusetts General Hospital, Associate Professor of Medicine at Harvard Medical School, and Associate Member of the Broad Institute of Harvard & MIT. He received his BA in molecular biology with Honors and Phi Beta Kappa in 2004 from the University of California, Berkeley. He received his MD with Alpha Omega Alpha in 2008 from the University of California, San Francisco. He received his MMSc in biomedical informatics in 2015 from Harvard Medical School. Dr. Natarajan completed his internship and residency in internal medicine at the Brigham and Women's Hospital, Harvard Medical School in 2011. He completed his clinical and research fellowship in cardiovascular medicine at the Massachusetts General Hospital, Harvard Medical School in 2015 and 2017, respectively.

Dr. Natarajan researches the genetic drivers of human atherosclerosis using genetic epidemiology, large-scale sequencing studies, digital health, and genotype-driven human investigation. His research laboratory spans the MGH Cardiovascular Research Center and the Broad Institute's Cardiovascular Disease Initiative. He leads several consortia and efforts towards these goals, as well as local clinical research in collaboration with Mass General Brigham patients.

In addition to his research efforts, Dr. Natarajan is a clinical cardiologist focusing on heart attack prevention, cardiovascular risk reduction, premature heart attack / coronary artery disease / peripheral arterial disease, lipid disorders, cardiovascular genetics, and cardiovascular consequences of blood disorders including clonal hematopoiesis / myelodysplastic syndrome based at the MGH Cardiovascular Disease Prevention Center.

To learn more about Dr. Natarajan's research, please visit http://natarajanlab.mgh.harvard.edu.

Clinical Interests:



Cardiovascular Disease Prevention Center
25 New Chardon Street
Suite 301
Boston, MA 02114-4774
Phone: 617-726-1843
Fax: 617-726-2203

Medical Education

  • MMSc, Harvard University
  • MD, UC San Francisco School of Medicine
  • MD, University of California, San Francisco School of Medicine
  • Residency, Brigham and Women's Hospital
  • Fellowship, Massachusetts General Hospital

American Board Certifications

  • Internal Medicine, American Board of Internal Medicine
  • Intermediate Care Facility, Mental Illness, Unknown Board
  • Cardiovascular Disease, American Board of Internal Medicine

Accepted Insurance Plans

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View my most recent research

Atherosclerotic cardiovascular diseases and their complications, including heart attack, are the leading causes of death in the United States and now worldwide. A large proportion of cardiovascular risk is heritable through known (e.g. lipids, blood pressure) and undiscovered mechanisms.

Dr. Natarajan leverages human genetic variation (germline and somatic), biomarkers, human physiology, and digital health to:

  • understand the biology of atherosclerosis in humans
  • identify new therapeutic targets to reduce cardiovascular risk
  • predict risk for developing a heart attack
  • identify individuals who may benefit from tailored preventive strategies

He conducts population-based translational research through large consortia (GLGC, NHLBI TOPMed, NHGRI eMERGE, NIH AllofUs, CHARGE, MVP, INVENT, PAGE, and others) as well as clinical research in collaboration with Mass General Brigham patients. His research laboratory spans the MGH Cardiovascular Research Center and the Broad Institute Cardiovascular Disease Initiative.