Accumulation of amyloid-β and tau proteins are related to brain network changes years before symptoms
Yakeel Quiroz-Gaviria, PhD
Yakeel Quiroz-Gaviria, PhD
Director, Multicultural Assessment and Research Center, MARC
Director, Multicultural Alzheimer's Prevention Program, MAPP
Associate Professor, Harvard Medical School
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- PhD, Boston University
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Dr. Quiroz is Associate Professor in the Departments of Psychiatry and Neurology. Her research is focused on the study of age-related cognitive and brain changes that may predispose individuals to develop dementia later in life. Understanding the pathophysiology of neurodegeneration and identifying biomarkers for early diagnosis of dementia, especially as measured by neuropsychology , biofluids and neuroimaging, are fundamental goals of her research. Her current studies use multimodal neuroimaging (e.g. PET, sMRI, fMRI, DTI) and integrate genetics, molecular and neuropsychological data to characterize some of the earliest changes associated with increased risk for Alzheimer's disease and other dementias.
Arboleda-Velasquez JF, Lopera F, O'Hare M, ... Johnson KA, Reiman EM, Quiroz YT. Resistance to autosomal dominant Alzheimer's disease in an APOE3 Christchurch homozygote: a case report. Nat Med. 2019 Nov;25(11):1680-1683. doi: 10.1038/s41591-019-0611-3. Epub 2019 Nov 4. PubMed PMID: 31686034; PubMed Central PMCID: PMC6898984.
Quiroz YT, Sperling RA, Norton DJ, Baena A, Arboleda-Velasquez JF, Cosio D, Schultz A, Lapoint M, Guzman-Velez E, Miller JB, Kim LA, Chen K, Tariot PN, Lopera F, Reiman EM, Johnson KA. Association Between Amyloid and Tau Accumulation in Young Adults With Autosomal Dominant Alzheimer Disease. JAMA Neurol. 2018 May 1;75(5):548-556. doi: 10.1001/jamaneurol.2017.4907. PubMed PMID: 29435558; PubMed Central PMCID: PMC5885174.
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