Explore This Center

About This Center

Diseases of and injuries to the brain and nervous system represent a tremendous health problem for society. Stroke, for example, is the leading cause of disability in the United States, and one of the leading causes of death worldwide. Rapid diagnosis and early treatment are critical for improving outcomes. The Center for Neurologic Emergencies (CNE) at Massachusetts General Hospital aims to generate new diagnostic tools and new therapies, to study and improve delivery of acute care, and to educate frontline providers in early recognition and treatment.

Who We Are

Our Co-Directors are Dr. Kori Zachrison and Dr. Joshua Goldstein. Dr. Zachrison is an Associate Professor of Emergency Medicine at Harvard Medical School, with specific expertise in health services research and healthcare quality. Dr. Goldstein is a Professor of Emergency Medicine at Harvard Medical School, with specific expertise in clinical trials of new treatments.

Our Goals

  • To perform early stage research and clinical trials, to bring new therapies to the bedside and improve outcomes
  • To educate present-day and future emergency providers on the best practices for diagnosis and emergency care
  • To develop best practices for clinical care, ensuring that all victims of neurologic injury receive the highest quality care available

Cooperation and collaboration with other groups are at the core of the Center's philosophy. Our partners include the Division of Neurocritical Care and Emergency Neurology in the Department of Neurology, the Division of Neuroradiology in the Department of Radiology, the Division of Trauma, Emergency Surgery and Surgical Critical Care in the Department of Surgery, and the Department of Neurosurgery.  Our partnerships ensure an interdisciplinary approach to our goals of research, education, and quality improvement.

Educational Opportunities

The Center publishes reviews and book chapters. We lecture nationally and internationally on the care of patients with neurologic emergencies. The Center offers educational sessions, lectures and training to fellows, residents, nurses, and midlevel providers.

In collaboration with Beth Israel Deaconess Medical Center, we support two annual CME courses for frontline providers focused on the care of patients with neurologic emergencies. One is offered in the spring through the Institute for ED Clinical Quality Improvement, and one in the fall through Harvard Medical School (click on links for details).

The Center also supports the advanced training and development of physicians interested in neurologic emergencies. One and two-year fellowships with a potential master's degree in public health offered by the Harvard School of Public Health are available to competitive applicants. Those interested in fellowship opportunities should contact Joshua Goldstein at jgoldstein@mgh.harvard.edu.


Our team performs a range of clinical trials in acute care. Many of these are in collaboration with the New England Strategies to Innovate EmeRgENcy Care Clinical Trials Network (SIREN) Group. The New England SIREN is a nation-wide, collaborative effort that conducts high-quality, multi-site clinical trials to improve the outcomes for patients with a range of emergency conditions. In collaboration with partners across New England, we both lead and participate in large scale definitive phase III trials for conditions such as traumatic brain injury, cardiac arrest, and others.

Observational studies

Our team performs a range of studies on both symptoms (such as headache and dizziness) as well as emergency conditions (such as stroke, intracerebral hemorrhage, and seizure). We collaborate closely with groups such as the J. Philip Kistler Stroke Research Center, the Division of Neurocritical Care and Emergency Neurology, and the Traumatic Brain Injury Research Program at Massachusetts General Hospital. We aim to improve the acute care and long-term outcomes for patients with neurological emergencies by conducting innovative research.

Health Services Research

We work closely with the Emergency Medicine Network (EMNet) within the Department of Emergency Medicine at Massachusetts General Hospital. We also help lead the American College of Emergency Physicians (ACEP) Emergency Quality Network (E-QUAL) Stroke Initiative, which aims to improve stroke care delivery in emergency departments nationally.

Past Research

Review past publications