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Diseases of and injuries to the brain and nervous system represent a tremendous health problem for society. For example, strokes are the leading cause of disability in the United States and one of the leading causes of death worldwide. Rapid diagnosis and early treatment are critical for improving outcomes. Led by Joshua Goldstein, MD, PhD, the Center for Neurologic Emergencies (CNE) at Massachusetts General Hospital aims to generate new therapies and educate frontline providers in early recognition and treatment.
The CNE is dedicated to improving the care of patients with neurological injuries through coordinated educational, research and quality improvement initiatives.
Cooperation and collaboration with other Mass General groups are at the core of the CNE's philosophy. Our partnerships with the various groups ensure an interdisciplinary approach to our goals of research, education and quality improvement.
We partner with collaborators from the industry and other institutions as well as the:
The Center for Neurologic Emergencies (CNE) supports the advanced training and development of physicians interested in neurologic emergencies and stroke. The center coordinates closely with the JPK Stroke Research Center to provide educational experience and mentorship for fellows in neurology, radiology and neurosurgery.
Fellows have worked clinically in the emergency department, pursued clinical and basic science research projects, participated in national large scale clinical trials and presented their work internationally.
One and two-year fellowships with a potential master's degree in public health from the Harvard School of Public Health are available to competitive applicants. Those interested in fellowship opportunities should contact Chun Mei Su at email@example.com.
Members of the CNE have provided lectures to medical students and residents in emergency medicine, neurology, trauma surgery and other venues. In addition, the center has hosted simulation workshops focused on training students and residents in the acute workup and management of a range of conditions such as stroke, seizure and meningitis.
The CNE publishes numerous reviews and book chapters as well as online material. Of note, we have published:
In collaboration with Beth Israel Deaconess Medical Center (BIDMC), we provide a popular annual continuing medical education course for frontline providers focused on the care of patients with neurologic emergencies.
New England SIREN Group
The CNE serves as the administrative hub for the National Institute of Health’s (NIH) “Strategies to Innovate Emergency Care Clinical Trials Network” (SIREN). The center coordinates trial management, training and enrollment efforts across New England, including partners at BIMDC, Boston Medical Center, Brigham & Women’s Hospital, Yale-New Haven Hospital and UMass Medical Center. Ongoing trials study new interventions in traumatic brain injury. Our public website is found here.
Stroke & Neurocritical Care Collaboration
The CNE works closely with the J. Philip Kistler Stroke Research Center, the Division of Neurocritical Care and Emergency Neurology and the Traumatic Brain Injury Research Program. The center aims to improve the acute care and long-term outcomes for patients with neurological emergencies such as acute stroke and traumatic brain injury by conducting innovative research and clinical trials.
Numerous original research articles have examined the pathophysiology, genetics, neuroradiology and clinical care management of ischemic and hemorrhagic stroke, advancing our understanding of these diseases. The current research is examining the surgical therapy of cerebellar intracerebral hemorrhage, anticoagulation management and reversal and early management of traumatic brain injury.
In collaboration with Johns Hopkins University, the CNE will initiate a novel study of dizziness in the acute setting. The symptom of dizziness is extremely common, and determining which patients have benign vs. more dangerous causes is quite difficult. This trial will study the use of video-oculography in the emergency department to help ensure the right diagnosis is made early. More information on the AVERT trial can be found here.
The CNE has participated in a range of industry-sponsored research in anticoagulation management and reversal, as well as clinical trials in neurologic and hematologic emergencies. In addition, the center has worked with industry partners examining products and services that need to be developed to advance the future of prehospital and emergency care for stroke.
Prior trials have studied transient ischemic attack, stroke, seizure and traumatic brain injury.
A list of Dr. Goldstein’s past publications can be found on PubMed.
Joshua N. Goldstein, MD, PhD, FACEP, FAHA, FNCSProfessor, Harvard Medical SchoolDirector, Center for Neurologic EmergenciesDepartment of Emergency MedicineMassachusetts General HospitalZero Emerson Place, Suite 3BBoston, MA firstname.lastname@example.orgPhone: 617-724-3290
Chun Mei SuProgram Manager, Center for Neurologic EmergenciesProgram Manager, Boston Neurological Emergencies Treatment Trials (NETT) GroupProgram Manager, New England Strategies to Innovate EmeRgENcy Care Clinical Trials Network (SIREN) GroupDepartment of Emergency MedicineMassachusetts General Hospital5 Emerson Place, Suite 119DBoston, MA email@example.comPhone: 617-726-4597
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