About Karen Miller, MD

Karen K. Miller, MD is the Chief of Neuroendocrine Unit and Director of the Neuroendocrine and Pituitary Tumor Clinical Center at the Massachusetts General Hospital, and a Professor of Medicine at Harvard Medical School. She is a practicing endocrinologist and a continuously NIH-funded physician-scientist who conducts clinical, translational and fundamental research to advance the care of patients with pituitary disorders and studies the impact of hypothalamic and pituitary hormone dysregulation on body composition, bone and brain. She has authored more than 200 peer-reviewed publications. Awards in in recognition of her work and mentorship include the Endocrine Society International Award for Excellence in Published Clinical Research in the Journal of Clinical Endocrinology and Metabolism and the Harvard Medical School William Silen Lifetime Achievement in Mentoring Award.

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Clinical Interests:



Mass General Endocrinology: Neuroendocrine & Pituitary Tumor Clinical Center
55 Fruit St.
Boston, MA 02114
Phone: 617-726-7948

Medical Education

  • MD, Johns Hopkins University School of Medicine
  • Residency, Brigham and Women's Hospital
  • Fellowship, Massachusetts General Hospital

American Board Certifications

  • Endocrinology, Diabetes and Metabolism, American Board of Internal Medicine

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Dr. Miller is an NIH-funded physician scientist who studies therapies for patients with pituitary disorders, with a focus on hormone deficiency and excess states, including growth hormone and androgens, on body composition and brain function.  Her research interests include hypopituitarism, acromegaly, androgen deficiency and replacement therapy in women and growth hormone deficiency and replacement therapy.


  • Selected publications:

    • Miller KK et al. Androgen deficiency in women with hypopituitarism. J Clin Endocrinol Metab. 2001; 86:561-7.
    • Miller KK et al. Effects of testosterone replacement in androgen-deficient women with hypopituitarism: a randomized, double-blind, placebo-controlled study. J Clin Endocrinol Metab. 2006; 91:1683-90.
    • Miller KK et al. Growth hormone deficiency after treatment of acromegaly: a randomized, placebo-controlled study of growth hormone replacement. J Clin Endocrinol Metab. 2010; 95(2):567-77.
    • Dichtel LE et. Al. Overweight/obese adults with pituitary disorders require lower peak growth hormone cut-off values on glucagon stimulation testing to avoid overdiagnosis of growth hormone deficiency. J Clin Endocrinol Metab. 2014 Dec;99(12) 4712-9.
    • Bredella MA et al. Body composition and ectopic lipid changes with biochemical control of acromegaly. J Clin Endocrinol Metab. 2017; 102(11):4218-25.
    • Colling C et al. The biochemical diagnosis of adrenal insufficiency with modern cortisol assays: Reappraisal in the setting of opioid exposure and hospitalization. Clin Endocrinol (Oxf). 2022; 96(1):21-9.
    • Tritos NA, Miller KK. Diagnosis and management of pituitary adenomas: a review. JAMA. 2023; 329(16):1386-98.

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