The Bastepe Lab strives to improve clinical management of endocrine and musculoskeletal disorders through fundamental research that involves genetics and molecular and cell biology.
Endocrinology Research & Clinical Trials
The Demay Laboratory at Massachusetts General Hospital is focused on understanding the role of the vitamin D receptor (VDR) in skeletal maturation and in cutaneous homeostasis.
For over two decades, the Diabetes Clinical Research Center at Massachusetts General Hospital has developed and evaluated innovative therapies for type 1 and type 2 diabetes.
Research in the Endocrine Unit focuses on metabolic bone diseases and mineral metabolism and ranges from trials of novel therapies for osteoporosis to use of genetically altered mice and cell biology to understand the factors that influence calcium and phosphate metabolism.
The Fitzgerald Laboratory explores the molecular mechanisms that cells use to export cholesterol and phospholipid to extracellular acceptor proteins, a process termed lipid efflux. We study how this process generates HDL and how HDL can modulate the innate immune system.
Thomas Gardella, PhD, is an Assistant Professor in Medicine and Biochemistry in the Massachusetts General Hospital Endocrine Unit, and conducts basic research on parathyroid hormone (PTH) and the PTH receptor.
The Massachusetts General Hospital Immunobiology Laboratory conducts basic and translational research focused on discovering novel treatments for autoimmune diseases, with a specific focus on type 1 diabetes.
The Kronenberg Laboratory at Massachusetts General Hospital uses genetically altered mice to study signaling by the PTH/PTHrP receptor in bone, bone development more generally and the relationships between cells of the osteoblast lineage and hematopoiesis.
The Laboratory of Molecular Endocrinology conducts basic research to discover the causes of diabetes and potential cures for the disease.
Research in the Mannstadt Laboratory at Massachusetts General Hospital focuses on diseases of the parathyroid glands and mineral metabolism.
Transforming Medicine Through Innovation
Research at Massachusetts General Hospital integrates the full spectrum of "bench to bedside" discovery. Laboratory scientists work collaboratively with clinicians to make discoveries and turn them into treatments, diagnostics and devices that improve our quality of life.