Research: I co-founded the Vasculitis Center at Johns Hopkins University and directed a multi-center, randomized clinical trial in Wegener's granulomatosis. The results of this trial were published in The New England Journal of Medicine (2005). I am currently the Co-PI of a second multi-center clinical trial in ANCA-associated vasculitis: Rituximab in ANCA-Associated Vasculitis HRAVe). The primary results of this trial were recently published in The New England Journal of Medicine (2010).
My most current research interest pertains to an emerging disease known as IgG4-related systemic disease (IgG4-RSD). My research group at the MGH made the seminal observation that rituximab therapy leads to the targeted reduction of the IgG4 subclass of immunoglobulins in this disorder.
Teaching: I gave the Sir James Cameron Lecture at the Royal College of Physicians (Edinburgh) in 2003. I delivered the Dunlop-Dottridge Lecture at the Canadian Rheumatology Association (2007), and gave the Woodbury Lecture at Dalhousie University in 2010.
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