With the addition of high-dose cyclophosphamide to graft-versus-host disease prophylaxis, simultaneous stem cell/kidney transplantation is feasible for selected patients who have partially HLA-matched donors.
149 13th Street
Charlestown, MA 02129
Hours: Monday–Friday, 8:00 am–6:00 pm
Explore This Research Lab
About the Lab
A major research goal of the Arnaout Laboratory is to elucidate the structure and function of integrins, cell adhesion receptors that play vital roles in normal physiology and disease and use the derived information in structure-based design of new and safer anti-integrin drugs targeting heart disease, fibrosis, and cancer.
Other research interests include elucidating mechanisms underlying cyst formation in Autosomal Dominant Polycystic Kidney Disease, transcriptional regulation of hematopoiesis, mechanisms of kidney regeneration, and design of microfluidic dialysis devices.
- View Dr. Arnaout's Harvard Stem Cell Institute Profile
- View Dr. Arnaout's Harvard Catalyst Profile
- Developmental and Regenerative Biology (DRB) Graduate Program
- Center for Regenerative Medicine
- Atomic structure of the integrin aVb3 in complex with macromolecular ligands
- Structure-based design of novel anti-integrin therapeutics
- EM structure of the leukocyte integrin CD11b/CD18 (aMb2)
- Role of adaptor proteins in regulation of leukocyte integrins
- Role of integrins in ischemia-reperfusion injury models
- Mechanisms of cyst formation in Autosomal Dominant Polycystic Kidney Disease
- Mechanisms of renal injury and regeneration
- Development of microfluidic devices for dialysis
- Transcriptional regulation of hematopoiesis
If you are interested in applying for a postdoctoral position, or are a Harvard PhD student interested in a laboratory rotation, please e-mail your CV (for student and postdoctoral) and reference letters (for postdoctoral) to: email@example.com
- Insights From New Study May Lead to Safer Drugs (Mass General press release)
- Dr. Arnaout was elected as member in the prestigious American Clinical and Climatological Association (ACCA) in Oct. 2019. Members of the ACCA comprise outstanding physicians selected on the basis of their leadership, scientific excellence, high level of integrity and professionalism. Active membership is limited to 250 physicians.
- Dr. Arnaout has received the 2018 Homer W. Smith Award from the American Society of Nephrology (ASN). Read more on the Research Institute blog, and the Harvard Medical School website.
- Dr. Arnaout has received the 2017 Kuwait Prize in Applied Medical Sciences from the KFAS. Read more in the MGH Awards and Honors newsletter.
- Mass General study finds a "Goldilocks" drug that prevents chronic kidney disease in primates — Massachusetts General Hospital News Articles, January 10, 2017
- Solving the problem of shape shifters — Harvard Gazette, 25 March 2014
- Cell Signaling: The MIDAS Touch — Nature Reviews, Molecular Cell Biology, May 2002
- Role Found for Protein in Kidney Disease — Harvard FOCUS, 12 January 2001
- Cell Adhesion Receptor Caught on Bended Knee — Havard FOCUS, 14 September 2001
- An Anthropomorphic Integrin —Science, 12 October 2001
- Integrin Binding Revealed — Nature Structural Biology, 2:181 1998
- Press Release
- Jan | 22 | 2020
Researchers have developed a method to design drugs that efficiently block rather than activate critical cell receptors which may help avoid adverse medication outcomes.
- Press Release
- Oct | 16 | 2019
Linemen's rapid weight gain can lead to hardening of heart, arteries, but problems may be offset with increased aerobic training
- Sep | 24 | 2019
Bone health specialists typically spend their time trying to figure how to slow or stop the bone loss that leads to osteoporosis. What if they could find a new way to stimulate the growth of new bone tissue instead?
- Press Release
- Jun | 25 | 2019
A biological pathway previously found to contribute to the impact of stress on the risk of cardiovascular disease also may underlie the increased incidence of such disease experienced by individuals with lower socioeconomic status.
- Press Release
- Jun | 13 | 2019
A study based at the Ragon Institute of MGH, MIT and Harvard has determined how a pregnant woman’s vaccine-induced immunity is transferred to her child, which has implications for the development of more effective maternal vaccines.
About the Nephrology Division
The Division of Nephrology at Massachusetts General Hospital is a leading provider of services for patients with kidney disease, including diagnosis and management of kidney diseases and medical management of renal transplantation.