Herscot Center

Herscot Center for Tuberous Sclerosis Complex

The Carol and James Herscot Center for Children and Adults with Tuberous Sclerosis Complex at Massachusetts General Hospital delivers specialized care for individuals suffering from Tuberous Sclerosis Complex.


Tuberous sclerosis complex, or TSC, is a genetic disorder with a wide range of symptoms that can affect people from birth through adulthood. The disorder is caused by a mutation in one of two genes, TSC1 or TSC2. A mutation in either of these genes interferes with the body's ability to control cell growth and division. The disorder can occur sporadically as the result of a spontaneous mutation, or it can be genetically inherited.

Dr. Thiele walks with patients

TSC affects 1 in 6,000 people worldwide and impacts both sexes and all ethnicities equally. The disorder may cause tumor growth in multiple organ systems, including the brain, skin, eyes, heart, lung, and kidneys. However, TSC's effects vary greatly and are unpredictable from one individual to another, even within the same family. While some people with TSC are cognitively normal and experience minor organ involvement, others are more severely affected with multi-system progressive tumors, intractable epilepsy, and mental retardation.

The neurological manifestations of TSC are often the most debilitating aspects of the disorder. Epilepsy is the most common medical condition associated with TSC. At least 60 percent and possibly more than 90 percent of people affected by TSC experience seizures at some point in their life. People with TSC may also develop learning disabilities and mental health and behavioral problems, such as attention deficit, depression, and autism.

For more information about tuberous sclerosis complex, visit the Herscot Center's Living with TSC website.

Second Opinion

Remote Patients: Second Opinion

This service is for prospective patients, unable to travel to Boston, who have questions about Tuberous Sclerosis Complex. This service allows you to receive a second opinion on your current diagnosis and treatment plan without having to travel to Dr. Thiele’s office.

If you are interested, please visit www.massgeneral.org/second-opinions. This website will provide you with the directions on how to start a case. Please remember to request Dr. Thiele as the reviewer of your case. If you have any questions please contact our office at 617-726-0241.

Contact Us

Yawkey center at MGH
The Yawkey Center at MGH

Administrative Offices:
Massachusetts General Hospital
175 Cambridge Street, Suite 340
Boston, MA 02114

Clinical Facilities:
Massachusetts General Hospital
Yawkey Building
6th Floor, Suite 6B
Boston, MA 02114



For more information or to make an appointment contact:
Ayahnna Williams
Phone: 617-726-0241
Fax: 617-726-0230

Driving directions to the Yawkey Center


  • More Patients, Better Medicine - 11/18/2016, Research

    Mass General Hospital’s Herscot Center for Tuberous Sclerosis Complex is an Evolving Model of Integrated Care for a Complex Disease

  • Tuberous Sclerosis Complex - 7/21/2009, Mass General

    The Carol and James Herscot Center for Tuberous Sclerosis Complex (TSC) at Massachusetts General Hospital and MassGeneral Hospital for Children is using genetic research to better understand TSC and other diseases like cancer, autism and obesity.

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