About TSC

An introduction to this complex condition.

Causes of TSC

Tuberous sclerosis complex (TSC) is a genetic disorder that results from a mutation in one of two genes that are present in virtually all cells.

Diagnosis of TSC

The disorder is well known for causing a wide variety of symptoms, which often differ from one individual to another.

How TSC Affects the Body

TSC can affect almost every major organ system, and its symptoms can be anywhere from mild to severe.

Medical Care

Early diagnosis, careful monitoring, and intervention can dramatically improve the long-term prognosis for people with TSC.


An overview of the research at the Herscot Center for TSC.

Talking about TSC

A guide to talking about TSC with family, friends, teachers, co-workers and doctors.

Patient and Parent Resources

A guide to resources and tools at Mass General and around the world.

Genetic Counseling

A genetic counselor can provide you with specialized information about TSC in a context that extends beyond clinical diagnosis and treatment.


A complex condition like TSC comes with a lot of medical terminology. Here are a few of the most common words you may encounter.