Scientific resources for researchers investigating X-linked Dystonia-Parkinsonism.
Induced Pluripotent Stem (iPSCs)
A collection iPSCs including affected men and women, unaffected controls, and carrier females is available at WiCell, Inc.
Lymphoblasts from dystonia patients including XDP (DYT3) and controls may be requested from the Dystonia Mass General Brigham Research Bank at MGH by contacting Amy Alessi, PhD.
FibroblastsAn extensive collection of fibroblasts from dystonia patients, including XDP (DYT3), were recently deposited at RUCDR Infinite Biologicals and will come online on a rolling basis.
Please note that fibroblasts are a limited resource. Availability will depend on how often lines are requested.
DNA from dystonia patients including XDP (DYT3) are available at Coriell .
Postmortem Brain Tissue
Samples from a limited number of postmortem XDP brains are available for research. Control tissue is not currently available. Brain collection efforts in the Philippines are described here.
Please note that due to the precious nature of this resource, a supplementary application and review by the XDP Brain Bank Tissue Committee is required before tissue distribution. Please contact Program Director Amy Alessi, PhD for additional information.
Conditional TAF1 floxed allele mice are available via The Jackson Laboratory.
Novel anti-C-TAF1 rabbit monoclonal antibodies
Monoclonal antibodies are available by request from CCXDP. Please contact Amy Alessi, PhD to request.
For questions, please contact Program Director Amy Alessi, PhD.
To inquire about genetic testing, enrolling in research studies or access to de-identified clinical data please contact:
Trisha J. Multhaupt-Buell, MS, CGC (she/her)
Genetic Counselor, Clinical Research Program Manager
Massachusetts General Hospital, Department of Neurology
Mass General Collaborative Center for XDP, Dystonia Partners Research Bank
114 16th St., Room 3011
Charlestown MA 02129-4044
Resources for Patients and Physicians
- Massachusetts General Hospital's Movement Disorders Unit
- Movement Disorder Society of the Philippines
- Dystonia Coalition (Rare Diseases Clinical Network)
- Dystonia Medical Research Foundation
- National Institutes of Health (NIH) Dystonias Fact Sheet
- Tyler's Hope for a Dystonia Cure
- X-linked Dystonia-Parkinsonism: Accelerating Research and Expanding Clinical Care