Ewing's Sarcoma
Contact Information
Orthopaedic Oncology Service
Mass General - Boston
55 Fruit Street
Yawkey Building, Suite 3B
Boston,
MA
02114
Phone: 617-724-3700
Fax: 617-726-6823
Explore Ewing's Sarcoma
Ewing's Sarcoma is a rare, highly malignant bone tumor made of small round cells of unknown origin. It is distinguished from other round cell tumors such as malignant lymphoma of bone, myeloma, neuroblastoma, rhabdomyosarcoma, small cell osteosarcoma and metastatic small cell carcinoma of the lung. Ewing's sarcoma is rare in African American communities and usually occurs between the ages of 10-20. Males are affected more frequently than females. Any bone may be involved, but the pelvis and lower extremities are the most common sites. The patient usually presents with pain, swelling, a mass and occasionally fevers, weight loss and fatigue for a few months. Blood tests may reveal anemia (low red blood cell count, low hemoglobin or hematocrit) or show an increase in the sedimentation rate (detects inflammatory, neoplastic/cancer, infectious and necrotic/cell breakdown decay processes). Pathologic fractures may be present. X-rays show a destructive lesion in the bone, a soft tissue mass, and destruction of the cortex which elicits a host response/new bone giving an 'onion skin' look around the tumor. Tumor tissue examined under the microscope shows the closely packed, small round cells.
Treatment for Ewing's sarcoma involves chemotherapy and surgical resection. Radiation therapy has also been used but with caution in young children with growth plate involvement to prevent significant growth deformity. The prognosis (outlook for survival) is now quite good due to advances in chemotherapy. Lung metastases may occur in 20-25% of patients at diagnosis or subsequently and are managed with different chemotherapy, radiation, resection or at times, stem cell transplants.
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- Acting Chief, Orthopaedic Oncology Service
- Program Director, Musculoskeletal Oncology Fellowship Program
- Assistant Professor of Orthopaedic Surgery, Harvard Medical School
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Santiago Lozano-Calderon, MD, PhD
- Orthopaedic Oncology Surgeon
- Assistant Professor of Orthopaedic Surgery, Harvard Medical School
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- Orthopaedic Oncology Surgeon
- Instructor in Orthopaedic Surgery, Harvard Medical School
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- Chief, Orthopaedic Spine Surgery
- Director, Spine Oncology & Co-Director, Stephan L. Harris Chordoma Center
- Associate Professor of Orthopedic Surgery, Harvard Medical School
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- Nurse Practitioner, Doctor of Nursing, Clinical Director for Orthopaedic Oncology Service
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- Inpatient Nurse Practitioner
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