Graduate Students

Visiting Graduate Student

The Harris Orthopedic Laboratory (HOL) at MGH specializes in translational research for orthopedic biomaterials and implants. HOL is looking to train MD/PhD and PhD students in polymeric material development and translational research in orthopaedics. The laboratory is a focal point in the orthopedic research community for development of new materials, designs and clinically relevant testing methodology for total joint replacements, which are implanted in over 1 million patients in the US alone each year. This is a great opportunity for science and engineering students looking for hands-on experience in biomedical applications.

We are interested in a variety of topics pertaining to orthopaedics such as improving the performance of materials, designs and developing methodologies to help bridge the gap between in vitro testing and in vivo performance of implantable devices. We are interested in treating orthopaedic conditions such as post-traumatic arthritis, peri-prosthetic osteolysis, peri-prosthetic and post-traumatic infection, and pain management.

We are open to collaborations where graduate students already enrolled in a PhD program in science or engineering with the pertinent experience can incorporate 1-2 years of laboratory training at the HOL into their thesis work.

Contact Person: Ebru Oral, PhD (eoral@mgh.harvard.edu)


Post-Doctoral Fellowships

Orthopaedic Materials Research Post-Doctoral Fellow

We are looking to hire a post-doctoral research fellow with strong background in engineering and materials, as well as with a keen interest in medical research. The fellow will be part of several projects aiming at the development of drug delivery devices in orthopedic applications, such as infections, pain management, and osteoarthritis.

The fellow will:

  • Investigate structure-property relationships of drug-incorporated thermoplastics and develop appropriate formulation and processing methods to optimize properties
  • Expand on the existing functionality and investigate the delivery, degradation and application properties of custom in-situ polymerizable gels
  • Investigate micro and nanoparticle synthesis for drug delivery

The applicant will work closely with other post-doctoral fellows and research engineers in characterizing the application specific properties of material formulations both in vitro and in vivo. The applicant will interface with core and off-site facilities to use analytical and processing tools.

Coursework and experience with polymeric materials is mandatory. Extensive experience with chemical and mechanical characterization tools is expected. Any experience with image processing, and preclinical work is a plus. Knowledge and experience with computational tools including Matlab, Python, and ImageJ are desirable.

The applicant is expected to have excellent communication skills in scientific writing and presentation. He/she will be responsible for presenting data and results to the PI and disseminating findings to the research community.

The applicant is expected to travel on occasion to collaborator sites and conferences regionally and nationally.

The applicant will work under the direct supervision of Prof. Ebru Oral, PhD, Associate Director.

Degree Requirements
Ph.D. in Materials Science, Polymer Science, Chemical Engineering, Polymer Chemistry, Mechanical Engineering or Biomedical Engineering.

How to Apply Please submit your resume and cover letter to Slav Lerner by April 30, 2021. We will review applications as we receive them. Anticipated start date: June - August 2021.


Post-Doctoral Fellow Training in Research Translation

We are looking to hire a post-doctoral research fellow with strong background in engineering and biology with a keen interest in translational research and development. The fellow will play a central role on each of the critical milestones of translational research and development, i.e. large scale GMP production, regulatory strategy, preparation of data needed for regulatory clearance, licensing of technology, education of end-users, and finally clinical studies, either in the form of pre-market trials or post-market surveillance. This is an excellent opportunity to learn various aspects of technology translation to clinical use.

The fellow will be responsible for various aspects of translation of existing device technologies – for instance a temporary spacer for the treatment of peri-prosthetic joint infection patients, a femoral implant design that reduces anterior hip pain among others. Most of the early proof of concept studies of the technologies in the pipeline have been completed. Under direct supervision of Prof. Orhun Muratoglu, HOL Director, the fellow will:

  • develop production-equivalent implants for preclinical testing by interfacing with outside vendors/subcontractors and guiding large-scale production according to good manufacturing practice (GMP)
  • participate in regulatory strategy development and design of the preclinical testing needed (often with the help of a pre-submission meeting with the FDA and outside regulatory consultants) for clearance of devices
  • be responsible in the execution of the strategic plan – preclinical testing, animal testing if needed, assembling the submission documents for the FDA, and responding to deficiency letters from the FDA.

The applicant needs to have excellent communication skills to coordinate internal meetings with the lab staff, external meetings with licensees and subcontractors, and communicate latest developments with all stakeholders and the research community.

The applicant will need to travel on occasion to various sites to oversee manufacturing of implants and testing performed by contract research organizations.

Degree Requirements
Ph.D. in Materials Science, Polymer Science, Chemical Engineering, Polymer Chemistry, Mechanical Engineering or Biomedical Engineering with a minor in Biology or equivalent.

How to Apply
Please submit your resume and cover letter to Slav Lerner by April 30, 2021. We will review applications as we receive them. Anticipated start date: June - August 2021.


Material Engineering & Preclinical Research

There are no available openings at this time.


Clinical Fellowships

There are no available openings at this time.


Undergraduate Internships

There are no available openings at this time.