Graduate Students

Visiting Graduate Student

The Harris Orthopedic Laboratory (HOL) at MGH specializes in translational research for orthopedic biomaterials and implants. HOL is looking to train MD/PhD and PhD students in polymeric material development and translational research in orthopaedics. The laboratory is a focal point in the orthopedic research community for development of new materials, designs and clinically relevant testing methodology for total joint replacements, which are implanted in over 1 million patients in the US alone each year. This is a great opportunity for science and engineering students looking for hands-on experience in biomedical applications.

We are interested in a variety of topics pertaining to orthopaedics such as improving the performance of materials, designs and developing methodologies to help bridge the gap between in vitro testing and in vivo performance of implantable devices. We are interested in treating orthopaedic conditions such as post-traumatic arthritis, peri-prosthetic osteolysis, peri-prosthetic and post-traumatic infection, and pain management.

We are open to collaborations where graduate students already enrolled in a PhD program in science or engineering with the pertinent experience can incorporate 1-2 years of laboratory training at the HOL into their thesis work.

Contact Person: Ebru Oral, PhD (eoral@mgh.harvard.edu)


Post-Doctoral Fellowships

Post-doctoral Research Fellow Position in Translational Research

General Overview
The pioneering efforts of the Harris Orthopaedics Laboratory have positively impacted the quality of life of millions of patients through innovation and evidence-based medicine since its inception in 1969. The mission of the laboratory is to improve patient outcomes through materials science and clinical research with an emphasis on orthopaedic applications.

Harris Orthopaedics Laboratory is focused on the development of polymeric and hybrid materials for applications in orthopaedics. We are looking to hire a fulltime post-doctoral research fellow for a 2-3 year appointment. The laboratory is a focal point in the orthopedic research community for development of new materials and test methods for total joint replacements, which are implanted in over 1 million patients in the US alone each year. This is a great opportunity for scientists looking to apply their basic knowledge in translational research.

The development of controlled release devices is a current focus for addressing problems such as peri-surgical pain management and infection in joint replacement and fracture fixation. The laboratory is involved in the conception of materials, development of application processes, characterization for the appropriate clinical indication and the safety and efficacy testing in pre-clinical disease and surgery models.

The post-doctoral fellow will be responsible for:

  • Designing formulations of thermoplastics and hydrogels for controlled release of drugs including analgesics and antibiotics.
  • Evaluating and tailoring polymeric structure property relationships.
  • Analyzing elution drug delivery characteristics.
  • Helping to design application devices.
  • Working with other team members supporting the preclinical studies for safety and efficacy.

Skills/Abilities/Qualifications
We are interested in interviewing candidates with a strong polymer science and materials science background. Experience with general polymer characterization methods, and familiarity with analytical chemistry, imaging, rheology and thermal/mechanical analysis methods is preferred. Experience with bacterial culture or testing antibacterial properties is also preferred.

Degree Requirements:
Ph.D. in Materials Science, Polymer Science, Chemical Engineering, Polymer Chemistry, Biomedical Engineering or equivalent experience with polymers is required.

Please submit your resume and cover letter to Slav Lerner at vlerner@mgh.harvard.edu by November 15, 2019. We will review applications as we receive them.


Material Engineering & Preclinical Research

Biomedical Engineering Position in Translational Research (Entry Level)

General Overview
The pioneering efforts of the Harris Orthopaedics Laboratory have positively impacted the quality of life of millions of patients through innovation and evidence-based medicine since its inception in 1969. The mission of the laboratory is to improve patient outcomes through materials science and clinical research with an emphasis on orthopaedic applications.

Harris Orthopaedics Laboratory is focused on the development of polymeric and hybrid materials for applications in orthopaedics. We are seeking a highly motivated individual for an entry-level research position to support our translational research program in implantable biomaterial development, starting in November 2019 – January 2020. This position is ideal for new engineering graduates interested in the medical application of basic research and is a great opportunity for those who want to gain some experience before continuing their education in graduate or medical school.

Responsibilities include, but are not limited to, the following activities:
Specific technical functions:

  • Laboratory formulation including preparation of macromers, polymers, polymer blends, polymeric consolidation
  • Modification of polymers including outside services such as radiation processing
  • Characterization of polymers on-site and off-site at available facilities in Boston including drug elution, mechanical and fatigue testing, wear testing, thermal and structural characterization
  • May include bacterial culture studies on processed UHMWPE materials using various assays
  • May include support for pre-clinical testing including preparing tissue specimens for post-surgical analysis and characterization of retrieved implants
  • May include data processing of material structure data such as gait analysis and micro-computed tomography image analysis

General laboratory functions:

  • Assembly, operation, maintaining operation protocols, scheduling management and some maintenance of assigned equipment
  • Ordering supplies and keeping track of related inventory
  • Maintaining clean equipment, glassware and laboratory space
  • Working alongside other research technicians, MD students, PhD students and post-doctoral fellows

Administrative/reporting functions:

  • Organizing and accurately maintaining written records of procedures and data
  • Generating and compiling experimental information/results in graphs, charts, and reports
  • Preparing written and/or verbal reports for supervisor and/or senior research personnel
  • Collaborating with team members and supervisor(s) in developing research methodologies and research objectives
  • Collaborating with team members and supervisor(s) in writing and editing material for publication; opportunity for authorship in publications

Skills/Abilities/Qualifications:

  • Must have BS. Non-engineering degrees will ONLY be considered with relevant experience
  • Must have at least one non-course based laboratory research experience, such as a summer internship or research assistantship
  • Coursework and/or internship experience in polymeric materials a plus
  • Coursework and/or laboratory experience with bacterial culture methods or animals a plus
  • Robust written and oral communication skills, attention to detail, and strong organizational skills are all expected. Independence, self-motivation, and a willingness to learn new skills are also vital for succeeding in this position
  • Must have solid, practical skills in Microsoft Office applications. Demonstrated proficiency in Matlab is a plus

How To Apply:
Please submit your resume, cover letter, and your unofficial transcript to Charlotte Leape, Research Technician at cleape@mgh.harvard.edu by October 31, 2019. We will start reviewing the applications as we receive them.


Clinical Fellowships

There are no available openings at this time.


Undergraduate Internships

There are no available openings at this time.