Intravenous Ketamine Clinic for Depression

The Intravenous (IV) Ketamine Clinic for Depression at Massachusetts General Hospital offers patients and their professional providers access to ketamine treatment for severe and refractory depression.

Overview

The Intravenous Ketamine Clinic for Depression at Massachusetts General Hospital combines advanced psychopharmacology expertise with knowledge stemming from a decade of ketamine research. We offer treatment for patients with severe and refractory depression using the medication ketamine given through intravenous infusion or through the nose (intranasal). We work collaboratively with the outpatient treatment team to develop an appropriate plan for each patient.

Our Focus

As a part of the Depression Clinical and Research Program at Mass General, we are committed to advancing our knowledge and ability to treat depression by integrating clinical care and innovative research. We do this through a number of avenues:

  • Our consultation services
  • The ketamine intravenous (IV) infusion service and intranasal ketamine clinic
  • Research studies focused on ketamine treatment

After a thorough consultation process, we offer IV infusions and intranasal ketamine maintenance to patients with severe depression or chronic suicidal ideation.

Learn More about the Intravenous Ketamine Clinic

Our Staff

  • Cusin, Cristina, MD

    617-726-6421

    Not Accepting New Patients

    Clinical Interests
    • Psychopharmacology
    • Electroconvulsive therapy
    • Deep brain stimulation
    • Mechanisms of placebo response
    • Genetics of mood disorders
    • Treatment-resistant depression
    Board Certifications
    • Psychiatry, American Board of Psychiatry and Neurology
    Locations
    • Boston: Depression Clinical and Research Program
  • Foster, Simmie L., MD, PhD

    617-724-5600

    Accepting New Patients

    Board Certifications
    • Psychiatry, American Board of Psychiatry and Neurology
    Locations
    • Boston: Depression Clinical and Research Program
  • Jain, Felipe A., MD

    617-726-8895

    Accepting New Patients

    Board Certifications
    • Psychiatry, American Board of Psychiatry and Neurology
    Locations
    • Boston: Depression Clinical and Research Program

Our Research

Grants

  • Randomized, double-blind ketamine augmentation in chronically suicidal, treatment-resistant major depression,” American Foundation for Suicide Prevention
  • New, rapidly-acting treatments for treatment-resistant depression (RAPID),” National Institute of Mental Health, PI Maurizio Fava, MD
  • Baseline insular dysfunction as a predictor of ketamine’s antidepressant effects in anxious depression,” NARSAD, Brain & Behavior Research Foundation

Publications

Recent Presentations

  • Ketamine Non-Responders Exhibit Pathological Increases in Extracellular Free Water Following Treatment–New Evidence of Astrocyte Pathology in Depression. Peyda S, Sydnor VJ, Kubicki M, Karayumak SC, Cheung J, Felicione JM, Shenton ME, Akeju-Johnson O, Pasternak O, Deckersbach T, Cusin C. Annual Meeting of American Society Clinical Pathology, Miami, May 29-June 1, 2018
  • Gender Differences in the Response to and Tolerability of Ketamine as a Treatment for Acute Depression. Freeman MP, Papakostas G, Hoeppner B, Mazzone E, Judge H, Cusin C, Mathew S, Sanacora G, Iosifescu D, Trivedi M, Fava M. Annual Meeting of American Society Clinical Pathology, Miami, May 29-June 1, 2018


Contact Us

Depression Clinical and Research Program

Consults and office visits are conducted through the Depression Clinical and Research Program.

Depression Clinical and Research Program
One Bowdoin Square, 6th Floor
Boston, MA 02114

Phone: 617-726-8727

Intravenous Ketamine Clinic

Ketamine IV appointments are conducted in the Intravenous Ketamine Clinic on the Mass General main campus on Tuesday and Thursday evenings from 5:30 pm-8:00 pm.

Intravenous Ketamine Clinic
Jackson Building, 1st floor
55 Fruit Street
Boston, MA 02114

 

Please note:

  • Patients must be connected to a primary mental health provider who initiates the referral to our clinic.
  • Your consultation may be billed to your insurance—please check with your insurer for coverage of visits at Mass General. Learn more about insurance at Mass General.
  • Ketamine administrations are currently NOT covered by insurance and are self-pay. All treatments must be paid out-of-pocket by the patient.

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