Clinical Research Participation

The Massachusetts General Hospital Department of Psychiatry has a wide variety of clinical research studies available.

If you are not eligible for clinical care within our system, you may be interested in our department’s research programs, which often include a clinical assessment and potential treatment from world-renowned experts. You do not need to be a patient at Mass General to participate in our department’s research.

We have active studies of most major psychiatric illnesses, including:

  • Depression
  • Bipolar disorder
  • Anxiety
  • OCD
  • Pediatric psychiatric conditions

Studies include clinical trials of new and experimental therapies that are not yet approved by the FDA, as well as established medications to be studied in combination with other treatments to determine whether combined treatments are more effective. We also study different types of psychotherapies, complementary and alternative treatments (including natural remedies, yoga, mindfulness and others), and new technologies for diagnosing and predicting psychiatric disorders. Some studies use placebos (sugar pills) for rigorous comparisons of the study drug, and others provide open treatment, where all participants receive the treatment of interest.

Our investigators are world-class clinician-researchers whose work advances the field and provides greater options for individuals with psychiatric illness. Hundreds of individuals each year have benefited from participation in our clinical research studies and obtained treatments that succeeded where others failed. If your condition has proven difficult to treat, you may be an excellent candidate for one of our research studies.

Learn more about these opportunities by completing our research intake form.

Research intake form